Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19심한 Covid-19를 가진 젊고 이전에 건강한 남성의 TLR7 변이체에 대한 유전자 스크리닝Clinical Trial Published on 2021-07-232022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] absence age blood cell Blood cells coding region Comorbidities Comorbidity COVID-19 database deficiency Deleterious determine Diagnosis Genetic genetic screening High-flow nasal oxygen host genetics imiquimod immunodeficiency in silico interferon interferon response IQR loss-of-function male median age men Mild missense variant oxygen Patient pre-symptomatic predicted predictors predisposition prospectively studied rare variant rationale reported required Result Risk factors SARS-CoV-2 Screening sequenced severe COVID-19 Stimulation Support the median the patient therapeutic interventions TLR7 treat Treatment type I underlie variant variants [DOI] 10.3389/fimmu.2021.719115 PMC 바로가기 [Article Type] Clinical Trial
Associations between dimensions of behaviour, personality traits, and mental-health during the COVID-19 pandemic in the United KingdomArticle Published on 2021-07-162022-10-29 Journal: Nature Communications [Category] Coronavirus, SARS, [키워드] affected age conditions COVID-19 pandemic demographics dimension explain Factors groups Health Human behaviour identify implication lockdown Medical research mental health Multiple Older pandemic positive predicted risk statistically traits underlie United Kingdom variable variables [DOI] 10.1038/s41467-021-24365-5 PMC 바로가기 [Article Type] Article
Altered Blood Cell Traits Underlie a Major Genetic Locus of Severe COVID-19심각한 COVID-19의 주요 유전적 위치의 기초가 되는 변경된 혈구 특성Article Published on 2021-07-132022-09-11 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 변종, 유전자 메커니즘, [키워드] age and sex Altered Analysis association basophil Blood blood cell Blood cells Blood samples candidate gene CCR1 CCR2 CCR3 Cell complex coronavirus disease Coronavirus disease 2019 COVID-19 eosinophil Eosinophil count European examined expression Genetic groups identify increased risk individual locus Major men Meta-analysis monocyte monocyte count Monocytes neutrophil Older pathophysiological mechanism performed phenome Phenome-wide association study. phenotype Phenotypes positive predicted regulated risk severe coronavirus disease severe COVID-19 significantly tested traits UK biobank underlie variant White blood cell [DOI] 10.1093/gerona/glab035 PMC 바로가기 [Article Type] Article
Kynurenic acid may underlie sex-specific immune responses to COVID-19Research Resource Published on 2021-07-062022-10-28 Journal: Science Signaling [Category] COVID-19, SARS, [키워드] Activation age Analysis chemokine Clinical outcome clinically Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cytokine abundance disease enzyme examined expression female females gene encoding Glutamate Health care worker immune response immune responses individuals Inflammation Inflammatory cytokine inhibit Kynurenic acid male Male sex males metabolism metabolite metabolites metabolome metabolomics Mortality Older outcome Patient patients performed positive positively correlated regulated reveal risk factor SARS-COV-2 infection serum T cell responses the disease underlie uninfected was reduced [DOI] 10.1126/scisignal.abf8483 PMC 바로가기 [Article Type] Research Resource
Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality인터페론으로 유도된 막횡단 단백질-3 유전자 변이체 rs12252는 COVID-19 사망률과 관련이 있습니다Article Published on 2021-07-012022-09-11 Journal: Genomics [Category] SARS, 변종, 유전자 메커니즘, [키워드] allele Clinical outcome COVID-19 COVID-19 phenotypes death examined Genetic variant genetics Genotype genotyped heterogeneous higher risk Hospital admission IFITM IFITM3 IFNγ individual interferon less log-rank test membrane protein Mortality Patient PCR-confirmed Plasma level Plasma levels Precision Probability public health risk factor SARS-CoV-2 SARS-COV-2 infection significantly lower subset survival transmembrane underlie variant Viral diseases with COVID-19 [DOI] 10.1016/j.ygeno.2021.04.002 PMC 바로가기 [Article Type] Article
COVID-19-Associated Cardiovascular ComplicationsReview Published on 2021-06-292022-11-01 Journal: Diseases [Category] COVID-19, [키워드] arrhythmia cardiac cardiovascular cardiovascular complication cardiovascular complications cardiovascular system chest pain Complication complications Coronavirus disease 2019 COVID COVID-19 drugs dysfunction Dyspnoea Effect Endothelial dysfunction event Factors G protein Health heart heart failure immune activation immune system immunothrombosis implicated include individual Infection Inflammation Injury Long Long COVID mechanisms Multiple myocardial injury Neutrophil extracellular traps occur overlapping Patient physiological mechanism presenting pro-inflammatory problems progression receptor reported SARS-CoV-2 survived Symptom Thromboembolic event Thromboembolic events thrombosis Treatment underlie venous viral invasion Withdrawal [DOI] 10.3390/diseases9030047 PMC 바로가기 [Article Type] Review
Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease종단 분석에 따르면 지연된 방관자 CD8+ T 세포 활성화와 초기 면역 병리로 인해 심각한 COVID-19와 가벼운 질병이 구별됩니다Article Published on 2021-06-082022-09-10 Journal: Immunity [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abnormality Abstract Activation Analysis analyzed Asymptomatic bystander bystander CD8+ T cell CD8 CD8+ cellular characterized clinical implications Cohort complement complex COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity cytokine Cytokines defined disease disease severities disease severity driven by group identify immune immune change immune changes immune defect immune pathology immune response immunopathology Immunophenotyping in some individual individuals infected individuals inflammatory factors Inflammatory responses interferon interleukin Kinetics longitudinal longitudinal analysis Mild Mild disease Necrosis oxidative phosphorylation pathological response pathology plasmablast response plasmablast responses recovery replacing response reveal RNA sequencing robust SARS-CoV-2 serum cytokine severe COVID-19 severe disease severity subsequent Symptom symptom onset systemic inflammation T cell TNF TNF-α Transcriptome Tumor tumor necrosis tumor necrosis factor underlie Viral Viral load [DOI] 10.1016/j.immuni.2021.05.010 PMC 바로가기 [Article Type] Article
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2Sars-CoV-2로 인한 뇌내피병증 및 뇌졸중의 병태생리학적 기전Review Published on 2021-06-012022-09-12 Journal: Journal of cerebral blood flow and metabolism : of [Category] MERS, 진단, [키워드] activate Activation Atypical cascade cerebrovascular complement condition connection contribute cytokine driving endothelia Endothelial cell endotheliopathy event global pandemic Hemorrhagic hypercoagulability identify implicated increase in independent Infection Inflammation Injury Ischemia mechanism modulate molecular overlap pathogenesis of stroke pathogenic mechanism pathophysiology pathway provide reducing resulting SARS-CoV-2 signaling pathways stroke suggested syndrome synergism triggered underlie variety vasculature younger patient [DOI] 10.1177/0271678X20985666 PMC 바로가기 [Article Type] Review
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex퍼즐 조각: Remdesivir는 다량체 SARS-CoV-2 RNA 의존성 RNA 중합효소 복합체를 분해합니다Article Published on 2021-06-012022-09-11 Journal: Cell biochemistry and biophysics [Category] SARS, 치료제, [키워드] Accelerated molecular dynamics simulation adenosine ATP binding complex computational simulations contribute Detachment disrupt domain domains finding flexible followed by global mortality higher affinity hosts Human mechanism molecular molecular dynamics Molecular dynamics simulation non-structural proteins Nsp7 NSP8 nucleotide PALM Perturbation piece RdRP Remdesivir Replication replicative reported RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-like coronavirus significantly Spread structure-based design subunit the SARS-CoV-2 underlie Viral RNA virus [DOI] 10.1007/s12013-021-00977-y PMC 바로가기 [Article Type] Article
Health indicators on adolescents reveal disparity and inequality on regional and national levelsResearch Published on 2021-05-282022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] African childbearing children comparable conducted correlation country COVID-19 case COVID-19 pandemic Data analysis death dropped education evaluate female finding genital groups Health health indicator HIV/AIDS incidence mortality rate National Region repeated Result selected sub-Saharan Africa supplementary material sustainable development goal underlie UNICEF [DOI] 10.1186/s12889-021-10989-1 PMC 바로가기 [Article Type] Research