6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in GermanyObservational Study Published on 2021-08-052022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] Admission age all-cause mortality all-cause mortality rate BMI Clinical outcome Coagulopathy Cohort cohort study Comorbidities COVID-19 death Diagnosis died discharged Factor female Follow-up Fund Germany Hospital admission Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient independent risk factor initial long-lasting median age men Mortality multivariable logistic regression outcome Patient patients hospitalized PCR-confirmed COVID-19 Prevalence protective factor readmission representing Result resulting Sex Treatment Ventilated women [DOI] 10.1371/journal.pone.0255427 PMC 바로가기 [Article Type] Observational Study
Case Report: C-Reactive Protein Apheresis in a Patient With COVID-19 and Fulminant CRP IncreaseImmunology Published on 2021-08-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] apheresis apheresis - therapeutic artificial ventilation Biomarker Blood blood plasma C-reactive protein Clinical deterioration complement Concentration consequence Course COVID-19 COVID-19 patient CRP CRP level diabete Dyspnea effective exhibited Fever first positive fulminant increase Inflammation intensive care unit introduced intubate lung Lung injury macrophage activation male Organ failure oxygen saturation Patient plasma Plasma level Pneumonia poor prognosis positive proceed processed pulmonary fibrosis pulmonary fibrosis (MeSH) ranged report respiratory Respiratory failure risk factor SARS-CoV-2 SARS-CoV-2 test selective Side effect subsequent the patient threshold concentration transfer triggering venous Ventilated Volume was performed X-ray [DOI] 10.3389/fimmu.2021.708101 PMC 바로가기 [Article Type] Immunology
Two-months quality of life of COVID-19 invasively ventilated survivors; an Italian single-center studyObservational Study Published on 2021-08-012022-10-05 Journal: Acta Anaesthesiologica Scandinavica [Category] 임상, [키워드] activity acute respiratory distress syndrome administration affected alteration ARDS carried cognitive Comorbidities complications COVID-19 COVID-19 disease Critically ill critically ill patients death demographics discharge discharged home distress exertional dyspnea Follow-up follow-up study follow-up time functional hospital hospital discharge Hospitalization ICU ICUs impairment Intensive intensive care intensive care unit invasive ventilation invasively ventilated patients Italian Laboratory majority Malnutrition median non-COVID-19 ARDS patients outcomes Patient patients Psychological Quality of life quality-of-life. reported required risk self-care severity scores single-center study survival survivor Survivors the patient Treatment variable Ventilated were assessed [DOI] 10.1111/aas.13812 PMC 바로가기 [Article Type] Observational Study
Energy requirements of long-term ventilated COVID-19 patients with resolved SARS-CoV-2 infectionObservational Study Published on 2021-08-012022-10-05 Journal: Clinical nutrition ESPEN [Category] SARS, 임상, [키워드] accompanied acute respiratory distress acute respiratory syndrome applicability average Bland-Altman plot calculated caused Clinical data coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient Critical care critically ill patients energy Energy expenditure Energy requirement evaluate evaluated examined gold standard Guidance hospitalized patients ICU independent Indirect calorimetry individual Infection intensive care intensive care units Invasive mechanical ventilation longitudinal management mechanically ventilated morbidity and mortality multi-organ failure Negative PCR Patient per day performed Predictive Predictive equations Resolution resolved resting retrieved retrospective SARS-CoV-2 SARS-COV-2 infection significantly significantly increased single-center study syndrome therapy Treatment Variation Ventilated were used [DOI] 10.1016/j.clnesp.2021.06.016 PMC 바로가기 [Article Type] Observational Study
Assessment of Ventilation and Perfusion in Patients with COVID-19 Discloses Unique Information of Pulmonary Function to a Clinician: Case Reports of V/P SPECTCase Report Published on 2021-07-202022-10-31 Journal: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine [Category] COVID-19, [키워드] assessment consecutive patient COVID-19 dead detect diagnose function induce Inflammation lung Perfusion preserved pulmonary Pulmonary embolism pulmonary inflammation report reversed SARS-CoV-2 severe hypoxemia Shunt SPECT vasculature Ventilated Ventilation ventilation/perfusion with COVID-19 [DOI] 10.1177/11795484211030159 PMC 바로가기 [Article Type] Case Report
Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndromeResearch Published on 2021-07-152022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome age ARDS body mass index changes in classical clinical trial Compliance correlated COVID-19 COVID-19 patient COVID-19 patients Dead space described difference Evolution include initial longitudinal longitudinal change mechanical ventilation median Mortality Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients not differ not different on mechanical ventilation Oxygenation PaO parameter Patient patients with COVID-19 PEEP physiological Positive end-expiratory pressure Respiratory failure Respiratory mechanics Respiratory system Result severity supplementary material syndrome two group Ventilated ventilatory were used [DOI] 10.1186/s13054-021-03665-8 PMC 바로가기 [Article Type] Research
An in vitro visual study of fugitive aerosols released during aerosol therapy to an invasively ventilated simulated patient에어로졸 치료 중에 방출 된 도망자 에어로졸에 대한 시험 관내 시각적 연구Research Article Published on 2021-07-142022-08-31 Journal: Drug Delivery [Category] SARS, 치료제, [키워드] aerosol aerosol droplet aerosol droplets aerosol therapy COVID-19 dose droplets endotracheal tube fugitive emissions high risk in vitro inhaler Intubated invasive invasive ventilation jet nebulizer limb mechanically ventilated movement noninvasive optical Patient position pressurized metered dose inhaler receiving released respiratory respiratory complication Respiratory complications resulting Schlieren imaging Selection the patient therapeutic therapy Transmission Ventilated ventilator ventilatory support vibrating mesh nebulizer was used were used [DOI] 10.1080/10717544.2021.1951893 PMC 바로가기 [Article Type] Research Article
Predictive Modeling of Morbidity and Mortality in Patients Hospitalized With COVID-19 and its Clinical Implications: Algorithm Development and InterpretationOriginal Paper Published on 2021-07-092022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] 24 hour 24 hours age assist AUC Blood urea nitrogen C-reactive protein canonical markers clinical clinical activity Clinical data clinical decision clinical marker coronavirus COVID-19 COVID-19 pandemic Deceased Decision making development Diabetic Disease progression disease severity effort elevated Endpoint Factor feature Final Glucose Gradient Health care system highest hospital Hospital stay Hospitalization ICU identify intensive care lab value lactate dehydrogenase LDH machine learning marker Model modeling morbidity morbidity and mortality Mortality New York New York City objective offered outcome outcomes Patient patient data performance peripheral oxygen saturation positive predict prediction Predictive Predictive modeling respiration rate Result Retrospective study risk SARS-CoV-2 severity strain Symptom temperature tested treated university Ventilated was obtained with COVID-19 [DOI] 10.2196/29514 PMC 바로가기 [Article Type] Original Paper
High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings침습적으로 환기 된 COVID-19 환자에서의 높은 HSV-1 재 활성화율 : 면역 학적 소견Research Article Published on 2021-07-012022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] activated acute respiratory distress acute respiratory distress syndrome analyzed Antiviral Beta CD38 CD8 T cell CD8 T cells Cohort Comprehensive Course COVID-19 COVID-19 patient decreased expression drop evaluated FACS analysis Factor Frequency functional Gene expression analysis HLADR HSV-1 IFI44L IFIT1 IL-1 Infection interferon interferon-stimulated genes invasive ventilation invasively ventilated patient invasively ventilated patients later phase lead MX1 occur patients PCR performed Peripheral blood Phase 1 Phase 2 predisposing factors pulmonary Quantitative Reactivation respiratory respiratory distress respiratory specimen respiratory specimens RSAD2 SARS-CoV-2 SARS-COV-2 infection screened secretion severe acute respiratory distress syndrome severe pneumonia shown significant increase significantly lower symptom onset syndrome T cells time Ventilated Whole blood [DOI] 10.1371/journal.pone.0254129 PMC 바로가기 [Article Type] Research Article
Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 PatientsResearch Article Published on 2021-06-292022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age Amino acid antibody antibody reactivity Antibody Response antigenic B.1.1.7 B.1.526 B1.351 CD40 ligand chemokine clinical outcomes Clinical severity clinical variables Cohort collected coronavirus Coronaviruses correlation COVID-19 cytokine Cytokine analysis EGF elevated Endemic Endemic coronaviruses epidermal epitope Epitopes Frame group growth factor HCoV-NL63 HCoV-OC43 human coronavirus OC43 Humoral immunity IgG antibody IL-10 IL-15 in vitro transcription individual interferon IP-10 mechanically ventilated membrane MERS-CoV Microarray Middle East Mutation nucleocapsid Older Older age older patient ORF overlap overlapping P.1 Patient patients probe profiles Protein Proteins Region respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 variant selected serum sample significantly significantly higher subset systemic cytokine the N protein the S1 protein translation Ventilated Viral variants [DOI] 10.1128/mBio.01229-21 PMC 바로가기 [Article Type] Research Article