viral spike – Page 7 – Communicable Diseases Research

Do Anti-androgens Have Potential as Therapeutics for COVID-19?

항안드로겐이 COVID-19 치료제로 가능성이 있습니까?

Article

Published on 2021-08-012022-09-11
Journal: Endocrinology [Category] SARS, 유전자 메커니즘,

Role of the Renin–Angiotensin–Aldosterone and Kinin–Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID

Review

Published on 2021-07-312022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] Abnormalities ACE2 Arrhythmias Asymptomatic blood pressure cardiovascular cardiovascular complication cardiovascular system cellular entry Complication consequence coronavirus 2 COVID COVID-19 COVID-19 pandemic described docking downregulation dysregulation enzyme heart failure homeostasis hypothesised immune response immune system implication include Infection kinin–kallikrein system life-threatening Long Long COVID mechanism membrane-bound Mild myocarditis occur pharmacological Protein RAAS renin–angiotensin–aldosterone system reported respiratory responsible resulting role SARS-CoV-2 Symptoms System Therapies Thromboembolism viral spike virus virus infection
[DOI] 10.3390/ijms22158255 PMC 바로가기 [Article Type] Review

Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19

ACE2 활동에 대한 Hydroxychloroquine의 조절 효과의 특성 : Covid-19와 관련된 새로운 통찰력

Research Article

Published on 2021-07-232022-09-10
Journal: BioMed Research International [Category] 치료제,

Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19

Research Article

Published on 2021-07-232022-10-27
Journal: BioMed Research International [Category]

Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19

Research Article

Published on 2021-07-232022-10-27
Journal: BioMed Research International [Category] COVID-19, SARS,

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

중증 COVID-19 환자의 인간 뇌 면역 반응에 대한 단일 핵 전사체 분석

Research

Published on 2021-07-192022-09-10
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] absence acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis biological processes Brain brain region brain tissue caused cells cellular activation Choroid plexus Control coronavirus coronavirus disease Coronavirus disease 2019 cortical COVID-19 COVID-19 patients death detect detectable Differential gene expression droplet examined Gene Expression gene regulatory network Host immune response immune response individual cell individual cells individuals Infection Macrophage macrophages Medulla oblongata microglia Mobility Monocytes Neuroinflammation neurological Neuropsychiatric oblongata Patient phagocytosis Prefrontal cortex proportion Region Result RNA sequencing S1 protein SARS-CoV-2 SARS-CoV-2 genome serotypes severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein stromal cells supplementary material time of death trajectory Transcription transcriptional change Transcriptional changes Transcriptome transcriptomes Viral viral spike viral spike protein viral transcript viral transcriptome viral transcripts virus was performed western blot
[DOI] 10.1186/s13073-021-00933-8 PMC 바로가기 [Article Type] Research

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection

인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다

Research Article

Published on 2021-07-162022-09-10
Journal: PLoS Pathogens [Category] SARS, 변종,

[키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic
[DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article

Binding of SARS-CoV-2 Fusion Peptide to Host Endosome and Plasma Membrane

Article

Published on 2021-07-132022-10-29
Journal: The journal of physical chemistry. B [Category] COVID-19, SARS,

Poor humoral and T-cell response to two-dose SARS-CoV-2 messenger RNA vaccine BNT162b2 in cardiothoracic transplant recipients

흉부 이식 수혜자의 2회 용량 SARS-CoV-2 메신저 RNA 백신 BNT162b2에 대한 체액 및 T 세포 반응 불량

Original Paper

Published on 2021-07-092022-09-11
Journal: Clinical Research in Cardiology [Category] MERS, 진단, 치료법,

[키워드] Abbott age analysed anti-SARS-CoV-2 average BioNTech/Pfizer (BNT162b2) vaccine blood sample Blood samples BNT162b2 BNT162b2 vaccine booster dose cellular response control group COVID-19 infection detectable domain domains dose ELISA Euroimmun Evidence evidence of excluded exhibited functional Genscript healthy heart humoral IgG immune response immune responses immunoassays Immunocompromised patient Immunocompromised patients immunogenicity Immunoglobulin infectious agent infectious agents inhibitory interferon interferon-γ lung majority membrane protein Messenger RNA Neutralizing antibodies neutralizing antibody nucleocapsid Organ transplant Patient patients peptides Pfizer-BioNTech Poor prime Qiagen QuantiFERON recipient recipients robust SARS-CoV-2 Seroconversion shown significant increase Specific T-cell response Spike protein stimulated T-cell T-cell Response tested titre Transplant recipients vaccination Vaccine Vaccines Viral viral spike was measured Whole blood
[DOI] 10.1007/s00392-021-01880-5 PMC 바로가기 [Article Type] Original Paper

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

Article

Published on 2021-07-072022-10-29
Journal: Nature Communications [Category] COVID-19, SARS,