Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients스파이크, 막 및 뉴클레오캡시드 SARS-CoV-2 단백질에 대한 강력한 T 세포 반응은 심각한 COVID-19 환자의 회복과 관련이 없습니다Article Published on 2020-09-222022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 진단, 치료법, [키워드] Activation CD4 CD8 clearance comparable COVID-19 COVID-19 severity Critical critical COVID-19 critical COVID-19 patient critical COVID-19 patients critical patients Diagnosis dominance donors effector T cell Frequency highest Hyperreactivity Hypothesis Immunity Immunopathogenesis immunopathology indicate induce magnitude membrane memory moderate N protein nucleocapsid patients peptide peptide pool Protein Proteins response robust S/M/N protein-reactive T cells SARS-CoV-2 SARS-CoV-2 spike spike Support survival T cell T cell response T cell responses T cells vaccination virus clearance [DOI] 10.1016/j.xcrm.2020.100092 PMC 바로가기 [Article Type] Article
Recognition of Potential COVID-19 Drug Treatments through the Study of Existing Protein–Drug and Protein–Protein Structures: An Analysis of Kinetically Active ResiduesArticle Published on 2020-09-212022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] α-difluoromethylornithine (DMFO) active sites Analysis applied approach approved drug boceprevir Chloroquine Community COVID-19 drug drug design facilitate hydrophobic IMPROVE in silico include interactions Ivermectin molecular normal-modes Potential Potential treatment Protein protein–drug interactions Proteins Recognition Remdesivir residue small molecule sofosbuvir spike glycoprotein virus [DOI] 10.3390/biom10091346 PMC 바로가기 [Article Type] Article
Novel Binding Mechanisms of Fusion Broad Range Anti-Infective Protein Ricin A Chain Mutant-Pokeweed Antiviral Protein 1 (RTAM-PAP1) against SARS-CoV-2 Key Proteins in SilicoBrief Report Published on 2020-09-172022-10-28 Journal: Toxins [Category] COVID-19, SARS, [키워드] antibody Antiviral antiviral agent binding mechanism caused chain characterized COVID-19 docking docking result experiment functions fusion fusion protein fusion proteins high affinity in silico mice New coronavirus novel pandemic pokeweed antiviral protein Protein protein-ligand Proteins Range ribosome-inactivating proteins ricin SARS-CoV-2 Structure target the SARS-CoV-2 therapeutic Therapies Toxicity Vaccines virus [DOI] 10.3390/toxins12090602 PMC 바로가기 [Article Type] Brief Report
Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent populationResearch Article Published on 2020-09-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] antibody B-cell blocked caused composed convalescent convalescent sera COVID-19 Diagnosis Dilution dominant epitope Efficacy elicit elicited epitope FIVE indicated Interaction linear epitope membrane mortalities neutralization activity Neutralizing neutralizing antibody Non-COVID-19 overlapped pandemic peptide performed Proteins SARS-CoV-2 SARS-CoV-2 vaccine sera specific antigen the vaccine Vaccine vaccine candidate viral infection [DOI] 10.1080/22221751.2020.1815591 PMC 바로가기 [Article Type] Research Article
Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune PerspectiveImmunology Published on 2020-09-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 ACE2 protein ACE2 proteins adhere animal model antibodies antibody binding-affinity block blocking caused classical Combination comparison COVID-19 Critical crystal structure develop effective eight epithelial epithelial cells epitope felines Host Human human ACE2 IgA dimer Infection Interaction interaction-synapse interactions interface interfere intestine Multiple Neutralizing antibodies neutralizing antibody pandemic Protein protein-protein interaction Proteins SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 transmission significant difference single antibody spike therapeutic therapy treating COVID-19 Vaccine virus X-ray [DOI] 10.3389/fimmu.2020.570018 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 Virion Stabilization by Zn BindingMolecular Biosciences Published on 2020-09-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] activated Antigen binding cellular expressed feasibility host cell Hypothesis Interaction involved lack maturation molecular dynamics computer simulation ORF7a orf7a and orf8 proteins ORF8 Protein Proteins SARS-CoV-2 Tetherin/BST2 virion Zinc zinc finger Zn binding [DOI] 10.3389/fmolb.2020.00222 PMC 바로가기 [Article Type] Molecular Biosciences
Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humansArticle Published on 2020-09-162022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] acting Analysis arising Betacoronavirus binding change circulation cryo-EM cryo-EM structure Cryoelectron microscopy domain enzyme Evolution feature glycosylated Haemagglutinin HKU1 host adaptation Human incompatible membrane fusion OC43 Particle promote Proteins Receptor binding receptors reveal sialic acid Structure utility viral evolution virion Virus structures zoonotic [DOI] 10.1038/s41467-020-18440-6 PMC 바로가기 [Article Type] Article
Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-21001 Published on 2020-09-162022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] analyses antigen processing Belonging Betacoronavirus computational tools conserved Contact contagious coronavirus creating Cytokine storm drug effective epitope Epitope-based vaccine Epitopes helper T cell humans Hyperactivation immune response immunogenic immunoinformatics immunopathology in vitro information novel novel coronavirus SARS-CoV-2 pandemic pathogen pathway Protein Proteins provide SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteome Spread Stage survival symptomatic and asymptomatic T cell T cell epitopes the SARS-CoV-2 Transmission Treatment unique Vaccine Vaccines Viral protein [DOI] 10.1098/rsos.201141 PMC 바로가기 [Article Type] 1001
Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domainArticle Published on 2020-09-102022-10-04 Journal: Nature Communications [Category] 변종, 치료제, [키워드] ACE2 acute respiratory syndrome antibody Antibody fragment therapy antiviral therapies association binding kinetics blockade Concentration coronavirus domain entry receptor experiment fusion generate Host human IgG1 Fc humanized identify IMPROVE in vitro inhibit inhibiting Interaction monomeric neutralization neutralization activity neutralize Neutralizing Proteins RBD receptor ACE2 Receptor binding domain SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike significantly Spread Support Therapies viral entry viral infection [DOI] 10.1038/s41467-020-18387-8 PMC 바로가기 [Article Type] Article
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age바이러스 부하, 성별 및 연령에 따른 SARS-CoV-2에 대한 생체 내 항바이러스 숙주 전사 반응Research Article Published on 2020-09-082022-08-13 Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] ACE2 Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age age and sex Antiviral antiviral response antiviral responses CD8A cells chemokine chemokines chemokines CXCL9 clinical manifestation clinical manifestations contribute coronavirus Course Culture cultures CXCL9 CXCR3 Cytotoxic T cell Cytotoxic T cells days post infection deficiencies deficiency demonstrated dependent on disease severity elapsed elevated examined expression Factor females Gene Expression Genes genomic granzyme B HAE Host host response host responses Host transcriptional response human airway epithelial humoral immune responses IFIT1 immune responses in vivo increase in individual induce Infection Inflammation inhibitor inhibitors interferon interferon signaling interferon-stimulated gene interferon-stimulated genes male mechanism nasopharyngeal natural killer negative controls neutrophil NF-κB nuclear OAS1 Patient PCR-confirmed populations profile Protein Proteins receptor reduced reduction in relative replicated respiratory reveal RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex shotgun shown Signaling specimen Swab T cells T helper Th1 transcript Transcription transcripts up-regulation Viral Viral load wound healing [DOI] 10.1371/journal.pbio.3000849 PMC 바로가기 [Article Type] Research Article