Monitoring peripheral neutrophil and T-lymphocyte subsets could assist in differentiating the severity and disease progression of coronavirus disease 2019말초 호중구 및 T-림프구 하위 집합을 모니터링하면 코로나바이러스 질병 2019의 중증도와 질병 진행을 구별하는 데 도움이 될 수 있습니다Research Paper Published on 2021-03-312022-09-10 Journal: Aging (Albany NY) [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Analysis analyzed Antiviral assist AUC baseline CD3+ CD3+CD4+ CD3+CD4+ T cells CD3+CD8+ CD4+ CD4+ T lymphocyte CD8+ T cells center characteristic clinical Clinical significance clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Cytotoxic T cell Cytotoxic T cells disease Disease progression evaluate expression help helper helper T cells lymphocyte Lymphocytes monitoring neutrophil neutrophil to CD4+ T lymphocyte ratio/N4R NK cell NK cells patients with COVID-19 peripheral lymphocyte Potential biomarker potential biomarkers progression Public receiver operating characteristic respiratory SARS-CoV-2 SARS-CoV-2 RNA detection severe acute respiratory syndrome Coronavirus severity subset T cell T cells T lymphocyte T-cell test negative therapy [DOI] 10.18632/aging.202701 PMC 바로가기 [Article Type] Research Paper
Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3 + CD8 + T-cell lymphocytopenia in COVID-19 patients without comorbidities on admissionCOVID-19 이환율 통계의 연령 분포에 따라 계층화된 연령 집단은 입원 시 동반 질환이 없는 COVID-19 환자에서 고유하게 연령 의존적 CD3 + CD8 + T 세포 림프구감소증을 식별합니다Research Paper Published on 2021-03-312022-08-31 Journal: Aging (Albany NY) [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age age distributions age-dependent immune features Analysis B cell C-reactive protein C-reactive protein concentration can be used CD3 CD4 CD8 CD8+ T cells cell count Cohort Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients defined develop distribution feature FIVE help identify immune indicated Infection Killer cell lymphocyte Lymphocyte count lymphocyte counts Lymphocyte subsets lymphocytopenia lymphopenia morbidity morbidity statistics natural killer natural killer cell not differ Pathogenesis patients plasma respiratory Retrospective study SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significantly Statistics stratified susceptibility T cell T cells T-cell the disease Therapeutic strategies therapeutic strategy [DOI] 10.18632/aging.202691 PMC 바로가기 [Article Type] Research Paper
How to Train Your Dragon: Harnessing Gamma Delta T Cells Antiviral Functions and Trained Immunity in a Pandemic Era드래곤 훈련 방법: 팬데믹 시대에 감마 델타 T 세포 항바이러스 기능 및 훈련된 면역 활용Review Published on 2021-03-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, 치료제, [키워드] Activation alterations Antiviral BCG Cancer coronavirus COVID-19 Cytokines Delta effective emergence of virus Evidence expansion feature function Gamma gamma delta T cell Health homeostatic Immune cell immune cells immune response Immunity innate immune response Innate immunity memory microbial infections mobilization pandemic Pathways Prevent recruitment SARS-CoV-2 coronavirus secretion stimulate subsequent subset T cell T cells the SARS-CoV-2 trained immunity treat Trigger triggers unique Vaccine variety Viral viral infection viral infections virus virus detection viruses [DOI] 10.3389/fimmu.2021.666983 PMC 바로가기 [Article Type] Review
Integrin Activation Enables Sensitive Detection of Functional CD4 + and CD8 + T Cells: Application to Characterize SARS-CoV-2 ImmunityImmunology Published on 2021-03-292022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation acute respiratory syndrome Antigen antigen specificity applicability application CD154 CD4 CD4+ T cells CD8 CD8+ T cells cell type clone CMV conformational change coronavirus detection EBV Epstein–Barr virus Ex vivo fluorescent Frequency functional HBV Hepatitis B virus integrin activation intercellular Ligand marker memory MONITOR monoclonal antibody mononuclear cell PBMCs Peripheral blood protocol SARS-CoV-2 sensitive shown T cell T cell responses T cells vaccinated individuals vaccination Whole blood [DOI] 10.3389/fimmu.2021.626308 PMC 바로가기 [Article Type] Immunology
Age-Related Dynamics of Lung-Resident Memory CD8 + T Cells in the Age of COVID-19COVID-19 시대의 폐 상주 기억 CD8 + T 세포의 연령 관련 역학Review Published on 2021-03-292022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] age aging process CD8 Cell Control coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactive developmental Dynamics Epitopes heterogeneous response heterogeneous responses homeostasis homeostatic Immune status Immunity in viral Influenza Lineage Local long-lasting lung lung dysfunction pathogen Pathogens pathology patients Pneumonia portion Pulmonary pathology resident memory respiratory respiratory tract respiratory viral infection respiratory viral infections Symptom T cell T cell epitopes T cells Treatment Viral Viral pneumonia [DOI] 10.3389/fimmu.2021.636118 PMC 바로가기 [Article Type] Review
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signalinglncRNA Snhg1-Vps13D 소포 트래피킹 시스템은 IL-7 신호 전달의 이중 효과 조절을 통해 메모리 CD8 T 세포 확립을 촉진합니다Article Published on 2021-03-242022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] acute viral infection Adaptive immunity Blimp1 CD8 CD8 T cell CD8 T cells Cell Cell Biology conserved convalescent COVID-19 patients differentiation Effect expression expression pattern Human IL-7 IL7R indicated Infection lncRNA mechanism membrane memory memory formation mice Non-coding RNAs pandemic pathogen pathogen-specific PBMC performed persistence promote Protein recent regulated Reinfection RNA Signaling Snhg1 STAT3 subset survival T cell T cells TCF7 transcriptional vaccination Vesicle viral infection Vps13D [DOI] 10.1038/s41392-021-00492-9 PMC 바로가기 [Article Type] Article
COVID-19 and HIV-Associated Immune Reconstitution Inflammatory Syndrome: Emergence of Pathogen-Specific Immune Responses Adding Fuel to the FireImmunology Published on 2021-03-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] absence activating Activation Adaptive immune response Adding amplification amplified antibody Antibody Response antigens arise B cell CD4 Characteristics characterized chemokine condition coronavirus disease COVID-19 cytokine Effect effective emergence fire fuel HIV-1 infection human immunodeficiency virus type 1 hyperinflammation IgA2 IgG1 antibodies IgG3 immune immune reconstitution inflammatory syndrome immune response immunomodulatory immunomodulatory effect immunopathology Inflammatory innate immune response innate response Interleukin-18 Macrophage Monocytes mycobacterial myeloid cell Neutrophils pathogen-specific pathway Patient pro-inflammatory produced promoted proportion response SARS-CoV-2 SARS-CoV-2 spike protein severe COVID-19 skewed syndrome T cell response T cells Th1 therapy [DOI] 10.3389/fimmu.2021.649567 PMC 바로가기 [Article Type] Immunology
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation회복기 COVID-19 환자는 지속적인 면역 활성화로 인해 내피 기능 장애에 취약Research Article Published on 2021-03-232022-09-10 Journal: eLife [Category] 진단, 치료제, [키워드] activated Activation acute infection Biomarker cardiovascular risk CD8 circulating circulating endothelial cells clinical clinical trials Complication condition convalescent correlated COVID-19 COVID-19 patient cytokine Cytokines diabetes effector cell effector T cell effector T cells elevated endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction event Frequency had more hallmark Health healthy controls Human hypertension immune activation immune effector cells initial mapped marker Measures non-COVID-19 patient Non-COVID-19 patients Numerous proinflammatory raising receptor recovered patients susceptible sustained T cells therapy Trial Vascular Vascular injury [DOI] 10.7554/eLife.64909 PMC 바로가기 [Article Type] Research Article
One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infectionMVA 벡터 백신을 1~2회 주사하면 SARS-CoV-2 상부 및 하부 호흡기 감염으로부터 hACE2 형질전환 마우스를 보호할 수 있습니다423 Published on 2021-03-232022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD antibodies antibody Cancer Cell chemokine clinical study Combination coronavirus coronavirus vaccine COVID-19 cytokine Deletion detection Diseases eight Express expressing form full-length S furin hACE2 hACE2 receptor human clinical trials IFNγ immune response immune responses Immunity immunized immunogenic in vitro indicated infected cells Infection infection with SARS-CoV-2 Infectious disease Infectious diseases inhibited injection Intramuscular injection intranasal lethal infection Lower respiratory tract lung Lungs mice modifications modified vaccinia virus modified vaccinia virus Ankara morbidity mRNAs Mutation nasal turbinate nasal turbinates neutralized neutralizing antibody nucleic acids occurred other infectious diseases pandemic passive transfer peptide Prevent prevented proline proline substitutions Protein Proteins provided pseudovirus purified RBD question RBD Receptor binding domain recombinant reduced Replication required respiratory S protein Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein severe acute respiratory syndrome Coronavirus severe disease shown signal peptide Significance single vaccination smallpox vaccine Spread stimulate subgenomic mRNA subgenomic mRNAs subgenomic viral mRNA subgenomic viral mRNAs T cells the S protein the SARS-CoV-2 the signal peptide transfer transgenic mice Transgenic mouse transgenic mouse model transmembrane domain transmembrane domains upper and lower respiratory tracts vaccination Vaccine vaccinia virus Ankara vector vectors Viral virus Virus vector weight loss [DOI] 10.1073/pnas.2026785118 PMC 바로가기 [Article Type] 423
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2동반 질환은 SARS-CoV-2에 대한 적응 면역 반응의 변화와 관련이 있습니다.Research Article Published on 2021-03-222022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료법, [키워드] Adaptive immune response Adaptive immunity age Analysis antibody Antibody Response Antibody responses Beta cells breadth CD4 Clinical outcome Cohort Comorbidities convalescent COVID-19 death diabetes envelope protein envelope proteins Ethnicity flow cytometry function functional functions Hospitalization Hospitalized illness illnesses immune system immunology magnitude nucleocapsid obesity reduced risk factor S1 domain SARS-CoV-2 serology severe COVID-19 Sex subject subjects symptom onset T cell T cells These data [DOI] 10.1172/jci.insight.146242 PMC 바로가기 [Article Type] Research Article