A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple SclerosisOriginal Research Published on 2021-03-222023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Adaptive immune response Autoimmunity Lymphocyte migration protein geranylgeranylation T cells [DOI] 10.3389/fimmu.2021.641188 PMC 바로가기 [Article Type] Original Research
T Cells Plead for Rejuvenation and Amplification; With the Brain’s Neurotransmitters and Neuropeptides We Can Make It Happen회춘과 증폭을 위한 T 세포 주장; 뇌의 신경전달물질과 신경펩티드로 우리는 그것을 실현할 수 있습니다Review Published on 2021-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] activate activated acute SARS-CoV-2 infection Adoptive Cell Therapy aging binding Brain Can Cancer Cell cell surface chemotactic chronic infections clinical trials CNS cytokine cytokine secretion damage decrease Depression diagnostic Dopamine Effect Effects Efficacy Ex vivo expressed extravasation Gene Expression Glutamate GnRH high risk Immunotherapy IMPROVE induce Infection infections Inflammation Injury integrin integrin-mediated killing limit microorganism microorganisms Migration Mortality natural Nerve-Driven Immunity nervous Neuropeptide Neuropeptide Y Neuropeptides neurotransmitter Neurotransmitters organization organizations other diseases other treatments overcome PD-1 proliferation protocols receptor Rejuvenation repeated SARS-COV-2 infection senescent Somatostatin Stress suggested System T cell T cells tested the cell therapeutic tissue repair trauma [DOI] 10.3389/fimmu.2021.617658 PMC 바로가기 [Article Type] Review
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumoniaResearch Article Published on 2021-03-222022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] acute lung inflammation age aging Cell Clinical outcome DNA methylation dysfunction functional impairment IMPROVE individual Influenza influenza pneumonia Injury Lung injury mechanism mice Older outcome provided Regulatory T cell SARS Coronavirus SARS-CoV-2 severe viral pneumonia Strategy T cells therapy Treg Treg cell viral infections Viral pneumonia younger patients [DOI] 10.1172/jci.insight.141690 PMC 바로가기 [Article Type] Research Article
DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in miceSARS-CoV-2 스파이크 단백질을 인코딩하는 DNA 백신 후보는 마우스에서 강력한 체액성 및 Th1 세포 매개 면역 반응을 유발했습니다Research Article Published on 2021-03-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS, [키워드] ACE2 Antigen balance binding breadth candidate cell-mediated immune response COVID-19 Critical died DNA vaccine DNA vaccines Effective vaccines elicited expressing followed by full length full-length S geometric mean geometric mean titer geometric mean titers GMTs highest humoral IFN-γ IgG IgG1 IgG2a infection with SARS-CoV-2 inhibit Interaction limit lowest magnitude mice neutralizing antibody pandemic peptide positive cell positive cells PRNT50 PRNT50 titers Protein robust SARS-CoV-2 spike SARS-CoV-2 spike peptide SARS-CoV-2 spike protein sera splenocyte splenocytes Stimulation T cell T cell responses T cells Th1 Vaccine Viral viral RBD wild type [DOI] 10.1371/journal.pone.0248007 PMC 바로가기 [Article Type] Research Article
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infectionSARS-CoV-2에 노출되면 탐지 가능한 바이러스 감염이 없을 때 T 세포 기억이 생성됩니다Article Published on 2021-03-192022-09-10 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] absence Asymptomatic CD4 CD8 close contact compose Coronavirus infection COVID-19 COVID-19 patient COVID-19 patients Critical detectable exposure to generate healthy donors Host immune response Immunity individuals Infection memory memory T cell memory T cells Patient proliferation provide Re-infection recovered COVID-19 patient Recovered COVID-19 patients Respiratory tract diseases SARS CoV SARS CoV-2 SARS-CoV-2 symptomatic T cell T cell response T cells T-cell T-cell immunity T-cell Response T-cell responses viral infection virus infection [DOI] 10.1038/s41467-021-22036-z PMC 바로가기 [Article Type] Article
Seroconversion stages COVID19 into distinct pathophysiological states혈청전환은 COVID19를 별개의 병태생리학적 상태로 단계화합니다.Research Article Published on 2021-03-162022-09-10 Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] Activation Alpha Analysis antibodies Antibody titer Antibody titers B cell subsets Biomarker biosignature clinical trial complement Complement activation COVID19 COVID19 patient cross-sectional Cytokines D-dimer Depletion driving end-organ damage endothelial damage Hematopoiesis heterogeneous heterogenous Hospitalized Human hyperinflammation Hypoalbuminemia IFN Increases increases in interferons knowledge lack ligands Limited Lymphocytes marker molecular mechanism molecular mechanisms Neutrophils NK cells pathophysiological Patient Platelets populations SARS Seroconversion Stage T cell T cells therapeutic intervention thrombotic thrombotic microangiopathy [DOI] 10.7554/eLife.65508 PMC 바로가기 [Article Type] Research Article
Clinical characteristics and peripheral immunocyte subsets alteration of 85 COVID-19 deathsResearch Paper Published on 2021-03-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] age and gender Analysis B cell C-reactive protein CD4 CD8 Characteristics clinical Clinical characteristics collected COVID-19 COVID-19 patient COX D-dimer death death in COVID-19 demonstrated develop died early stage electronic medical records evaluate groups high risk hospitalized COVID-19 patient identify immunological characteristics increased the risk laboratory data Lymphocyte count Lymphocytes Mortality multiple logistic regression natural killer cell neutrophil neutrophil count NK cells Patient reduce researcher risk factor risk of death SARS-CoV-2 SARS-COV-2 infection severe disease significant decrease significantly higher significantly lower subset T cell T cells Total White blood cell Wuhan, China [DOI] 10.18632/aging.202819 PMC 바로가기 [Article Type] Research Paper
The Mechanism of PEDV-Carrying CD3 + T Cells Migrate into the Intestinal Mucosa of Neonatal PigletsArticle Published on 2021-03-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition blood circulation CD3 CD3+ T cells CD4 CD8 Contact demonstrated epidemic diarrhea implication increase in Infection integrin intestinal intestinal epithelial cell intestinal epithelium intestine intranasal inoculation Migration multiplicity of infection nasal Neonatal neonatal piglets occur Pathogenesis PEDV Prevent survived T cell T cells therapy transferred Viral transmission virus [DOI] 10.3390/v13030469 PMC 바로가기 [Article Type] Article
Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients코로나19 환자 중 제2형 당뇨병의 면역학적 특성Observational Study Published on 2021-03-112022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, 임상, [키워드] Admission analyzed CD4 CD8 clinical Concentration Context contribute COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 pneumonia cytokine Cytokines D-dimer declined diabetes Diabetes Mellitus Diabetic diabetic patients dimer disease elevated evaluated feature ferritin flow cytometry groups high mortality Hospitalized hyperglycemia Identifier IL-10 IL-6 IL-8 IL‐6 IL‐8 Imbalance Immune cell immune cells immune system immunological immunological characteristics indicated laboratory parameter Laboratory parameters Lymphocytes lymphopenia Mortality Myoglobin nitrogen NK cell NK cells non-survivor Non-survivors objective participant pathogenic mechanism pathogenic mechanisms patients Pneumonia reduced reduction reductions Registration remained Result Retrospective study Sample serum serum concentrations severity significantly subset survival survivor Survivors T cell T cells T lymphocytes Th1/Th2 ratio TNF‐α Type type 2 diabete type 2 diabetes Type 2 diabetes mellitus urea urea nitrogen were measured [DOI] 10.3389/fendo.2021.596518 PMC 바로가기 [Article Type] Observational Study
T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19T 세포 활성화, 고도로 무장된 세포독성 세포 및 단핵구 CD300 수용체 발현의 변화는 중증 COVID-19 환자의 특징입니다Comparative Study Published on 2021-03-112022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] activated Activation adaptive alteration Analysis analyzed association CD300a CD300c CD300e CD4 CD8 cells characterized Clinical characteristics clinical phenotype Clinical sign cohort of patient correlated Correlation analysis COVID-19 cytotoxic described double negative expression expression pattern flow cytometric study follicular granzyme B help HLA-DR host immune responses immature Immune cell immune system Immunopathogenesis infected with SARS-CoV-2 Laboratory low expression Mild moderate monocyte Monocytes NK cell NK cells Patient patients performed receptors severe COVID-19 severe disease severity shift T cell subset T cells [DOI] 10.3389/fimmu.2021.655934 PMC 바로가기 [Article Type] Comparative Study