immune responses – Page 72 – Communicable Diseases Research

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

JAK-STAT 경로 억제 및 COVID-19 치료에 미치는 영향

Review

Published on 2021-06-012022-09-11
Journal: Postgraduate medicine [Category] 유전자 메커니즘, 치료법,

Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates

2개의 새로운 아데노바이러스 매개된 COVID-19 백신 후보로 생쥐와 붉은털 원숭이의 프라임 부스트 백신 접종

Research Article

Published on 2021-06-012022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술,

[키워드] Adenovirus animals anti-RBD anti-S binding antibody candidate CD4 cells changes COVID-19 vaccine COVID-19 vaccines detectable dose-dependent manner elicit evaluated FIVE followed by full-length human adenovirus 49 vector IFN-γ IL-2 immune response immune responses Immunity immunization immunogenicity macaque macaques mice mice and non-human primates nCoV pathologic peptide peptides preparation prime-boost regimen prime-boost vaccination priming pseudovirus neutralizing antibody response rhesus macaque rhesus macaques SARS-CoV-2 spike protein simian adenovirus 23 vector Specific Spike protein T cell T-cell Response the vaccine trials vaccination Vaccine
[DOI] 10.1080/22221751.2021.1931466 PMC 바로가기 [Article Type] Research Article

Longevity of SARS-CoV-2 immune responses in hemodialysis patients and protection against reinfection

혈액투석 환자에서 SARS-CoV-2 면역 반응의 수명 및 재감염에 대한 보호

Article

Published on 2021-06-012022-09-11
Journal: Kidney international [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] anti-RBD antibodies antibody antibody status asymptomatic infection baseline cellular immunity center circulating antibodies circulating antibody COVID-19 detectable develop eight Evidence evidence of had no Hemodialysis humoral immune response immune responses independent of Infection investigated Kidney disease less Longevity no evidence of nucleocapsid protein Patient PCR positive receiving Receptor binding domain reduced Reinfection remained retained SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-COV-2 infection screened serology seronegative seropositive significantly symptomatic and asymptomatic T cell T cell responses T-cell responses
[DOI] 10.1016/j.kint.2021.03.009 PMC 바로가기 [Article Type] Article

Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19

말초 면역 세포의 단일 세포 후성유전체 환경은 COVID-19에서 회복 중인 개인의 훈련된 면역 확립을 보여줍니다

Article

Published on 2021-06-012022-09-11
Journal: Nature cell biology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법,

[키워드] accelerated activated acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis antibody asymptomatic infection B cell B-cell cause CD14 CD16 CD8 chromatin collected coronavirus coronavirus 2 COVID-19 death developmental differentiation epigenomic exhibited expansion healthy donors highlighting immature Immune cell immune cells immune response immune responses Immunity Immunological memory individual individuals Infection IRF1 Lineage Memory cells monocyte Monocytes mononuclear cell performed Peripheral blood Peripheral blood mononuclear cells Plasma cells profile promote reported reveal SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe complication severe complications single-cell T cell T cells
[DOI] 10.1038/s41556-021-00690-1 PMC 바로가기 [Article Type] Article

Immune Responses to SARS-CoV2 Mirror Societal Responses to COVID-19: Identifying Factors Underlying a Successful Viral Response

Concept Paper

Published on 2021-05-292022-10-28
Journal: Biology [Category] COVID-19,

[키워드] adaptive adaptive immune system biological analogy caused COVID-19 COVID-19 pandemic Critical cytokine Cytokine storm Cytokine storms disease effective effective strategy Effectiveness employment epidemiological event explain Factor help identify identifying immune immune response immune responses immune system immunological include individuals information Interaction learning measure Mirror morbidity and mortality pandemic pathogen pathogen clearance pathogen-specific pathogenic pathogenic challenge Pathogens positive feedback loop PROTECT public health reduce response SARS-CoV2 simple social cytokine storm social immunity understanding virus with COVID-19
[DOI] 10.3390/biology10060485 PMC 바로가기 [Article Type] Concept Paper

Comprehensive Comparison of RNA-Seq Data of SARS-CoV-2, SARS-CoV and MERS-CoV Infections: Alternative Entry Routes and Innate Immune Responses

SARS-CoV-2, SARS-CoV 및 MERS-CoV 감염의 RNA-Seq 데이터 종합 비교: 대체 진입 경로 및 선천적 면역 반응

Immunology

Published on 2021-05-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] A549 A549 cell A549 cells ACE2 Analysis Calu3 CaLu3 cells Cell cell entry cell type cells Comparative analysis complex Comprehensive COVID-19 patients dataset dose Evidence evidence of example expressing expression Factor human ACE2 IFNs immune responses imperative inefficient Infection Injury Innate innate immune response innate immune responses Innate immunity interferon interferons investigated ISGs mechanism MERS-CoV organs Pathogenesis pathogenesis of COVID-19 performed produced response Result RNA-seq data route SARS-CoV SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection second Support therapy These data TMPRSS2 transduced vector Viral viral entry virus virus entry route
[DOI] 10.3389/fimmu.2021.656433 PMC 바로가기 [Article Type] Immunology

Maintenance of neutralizing antibodies over ten months in convalescent SARS‐CoV‐2 afflicted patients

회복기 SARS-CoV-2 환자에서 중화항체를 10개월 이상 유지

Original Article

Published on 2021-05-272022-09-01
Journal: Transboundary and emerging diseases [Category] COVID19(2023년), MERS, SARS, 진단,

Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2

무증상 COVID-19: SARS-CoV-2에 대한 효율적인 항바이러스 면역으로 질병 내성

Article

Published on 2021-05-272022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] accompanied addition antibodies Asymptomatic Asymptomatic case Asymptomatic cases asymptomatic patient asymptomatic patients CD169 Cell cellular characterized COVID‐19 COVID‐19 patient COVID‐19 cytokine Cytokines disease Disease progression disease tolerance elicit expressing gene signatures growth factor Growth factors highlight identify immune pathway Immune phenotype immune response immune responses Immunity immunology Inflammatory response insight less limit mechanism Microbiology, Virology & Host Pathogen Interaction monocyte Monocytes neutralization capacity neutralizing antibody neutrophil Neutrophils Peripheral blood prevent disease progression progression proportion protective immune response protective mechanisms responses robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Symptom Symptomatic patients systemic systemic level Th17 cell Th2 therapeutic target therapeutic targets Tolerance transcriptomic profiles
[DOI] 10.15252/emmm.202114045 PMC 바로가기 [Article Type] Article

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

Malawian Plasmodium falciparum 분리물의 전체 게놈 분석은 임상 말라리아에 대한 대립 유전자 특이적 면역의 가능한 표적을 식별합니다

Research Article

Published on 2021-05-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] acquired immunity acquisition allele Analysis Antigen antigens approach approaches characterized collected deaths develop disease expand Frequency genes encoding identify immune evasion immune responses Immunity immunologically individual infections investigated isolate longitudinal study malaria malaria parasite malaria parasites multiple allele multiple alleles naturally acquired immunity Plasmodium falciparum polymorphic site polymorphism Prevent Previous studies protective immune response Protein repeated repertoire representing response resulting sequence symptomatic individual symptomatic individuals Symptoms target targets thought Transmission understanding Vaccine vaccine candidate vaccine candidates variant whole genome sequence Whole-genome sequence
[DOI] 10.1371/journal.pgen.1009576 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees

우려되는 SARS-CoV-2 변이체는 COVID-19 회복기 기증자와 백신에서 체액성 반응을 부분적으로 탈출하지만 T 세포 반응은 회피하지 않습니다

Article

Published on 2021-05-252022-09-11
Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, 치료기술,

[키워드] addition antibody antigens B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 CD4 Cellular immune response cellular immune responses Cohort COVID-19 convalescent donor COVID-19 disease cross-reactivity detect elicited exhibited functional HCW Health care Health care worker homologous humoral Humoral and cellular immune responses Humoral immunity Immune escape immune response immune responses individuals Mild Mild COVID-19 disease mononuclear cell mononuclear cells mutated Mutation neutralizing capacity no difference no differences not affected peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells Protein raised recall Region required S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose seronegative single vaccination Specific stimulated T cells T-cell activation T-cell Response T-cell-mediated immunity vaccination vaccinee variant variants virus virus-specific T cell wild type
[DOI] 10.1126/sciimmunol.abj1750 PMC 바로가기 [Article Type] Article