Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection SeverityHypothesis Published on 2020-07-242022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] ACE2 ACE2 receptors activate Activation acute respiratory syndrome age angiotensin-converting enzyme 2 antioxidant Antiviral Cell conditions coronavirus COVID-19 decrease disease pathogenesis downregulating EGCG ENhance expression Factor flavonoid flavonoids Genes high affinity Hypothesis immune response increase infections Inflammation inflammatory process Innate immunity modulate modulated Nrf2 obesity oxidative stress pathway Prevent prevention priming PROTECT Proteins receptor reduce reducing respiratory epithelial cells respiratory viral infections ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severity spike glycoprotein thymoquinone transcription factor viral entry viral infection viral life cycle Vitamin D3 [DOI] 10.3390/antiox9080659 PMC 바로가기 [Article Type] Hypothesis
A comparative study of the laboratory features of COVID‐19 and other viral pneumonias in the recovery stageResearch Article Published on 2020-07-212022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] COVID-19, MERS, SARS, [키워드] affected Analysis Care clinical clinical recovery conditions Control control patient COVID‐19 COVID‐19 patient COVID‐19 CRP decrease demonstrated Elevation eosinophils ESR follow‐up full recovery IgG IgG antibody Immunity IMPROVE laboratory feature laboratory parameter lymphocyte Lymphocytes MCH moderate neutrophil Neutrophils Pandemics Patient positive Protein Proteins recovery Result SARS‐CoV‐2 SARS‐CoV‐2 stages total protein Viral pneumonia [DOI] 10.1002/jcla.23483 PMC 바로가기 [Article Type] Research Article
Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoproteinArticle Published on 2020-07-172022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis Antigen caused Cell conserved contribute coronavirus Coronaviruses Cryo-electron microscopy cryo-EM structure Cryoelectron microscopy form glycoprotein Health Hepatitis highly pathogenic Host information linker mechanism membrane membrane fusion MERS-CoV MHV motif mouse Protein Proteins receptor respiratory syndrome coronavirus responsible S2 subunit SARS virus SARS-CoV SARS-CoV S SARS-CoV-2 SARS-like coronaviruses significantly spike glycoprotein Structure target therapeutic therapy trimer upstream Vaccine viral entry viral membrane virus [DOI] 10.1038/s41467-020-17371-6 PMC 바로가기 [Article Type] Article
The bright and dark sides of protein conformational switches and the unifying forces of infections단백질 구조 전환의 밝은 면과 어두운 면과 감염의 통합력Review Published on 2020-07-152022-09-10 Journal: Communications Biology [Category] SARS, 신약개발, 치료제, [키워드] Alter Bacterial bacterial toxins cellular entry Combination conformation conformational derived proteins domain functions glycoprotein Host identify Infection infections membrane molecular pathogen Pathogenesis Pathogens Perspective Protein Protein sequence analyses Proteins sequence sequences similarity spike glycoprotein Spike protein structural biology switching the Spike toxins virus viruses [DOI] 10.1038/s42003-020-1115-x PMC 바로가기 [Article Type] Review
Temperature Sensitivity: A Potential Method for the Generation of Vaccines against the Avian Coronavirus Infectious Bronchitis VirusArticle Published on 2020-07-142022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Accessory genes affected allelic antigenic clone contagious core body temperature coronavirus days post infection defined determinant determine dissemination effectively deliver eyelid function Generation Genes genetics Host IBV in vivo Infectious Bronchitis Virus investigated lesion molecular mRNA synthesis Mutation pathogenic Potential Proteins replicase replicate respiratory pathogen RNA synthesis sensitivity Seven strain temperature temperature sensitive temperature sensitivity tissue upper respiratory tract Vaccine design Vaccine development vaccine platform viral replication was used [DOI] 10.3390/v12070754 PMC 바로가기 [Article Type] Article
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responsesArticle Published on 2020-07-142022-10-04 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] age antibody Antibody Response Convalescent patients COVID-19 COVID-19 in patient diagnostic effective generate Human immune system IgG IgG and IgM immune system lactate dehydrogenase LDH lymphocyte Microarray N proteins nsp5 Orf9b Patient predicted Protein Protein array analysis Proteins provide respond response S1 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins SARS-CoV-2 proteome sera the N protein the SARS-CoV-2 therapeutic Vaccination strategies viral infection Viral proteins [DOI] 10.1038/s41467-020-17488-8 PMC 바로가기 [Article Type] Article
Mutational Frequencies of SARS-CoV-2 Genome during the Beginning Months of the Outbreak in USAArticle Published on 2020-07-132022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accumulate accumulated accumulated mutations America Analysis analyzed bioinformatics changes in circulating conserved COVID-19 determine functions Genetic variation Genome Helicase help Limited majority Month Mutation nsp10 NSP11 Nsp7 ORF3a ORF6 ORF7b ORF8 pandemic potential therapeutic target Protein Proteins provide RdRP Receptor binding domain Region Replication reported RNA virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 spike Spread submitted USA viral gene viral genome Viral protein virus propagation WHO [DOI] 10.3390/pathogens9070565 PMC 바로가기 [Article Type] Article
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2Virus-Cell Interactions Published on 2020-07-082022-10-30 Journal: Journal of Virology [Category] COVID-19, MERS, [키워드] A549 cell ADAP2 adaptive immune responses Analysis Antigen Antiviral Cell cell line cell tropism cells cellular Contact Control coronavirus Coronavirus infection CoV CoV infection Critical determinant domain ectopic expression Efficiency effort expand expression facilitate Factor Fever growth HCoV-OC43 hepatoblastoma HepG2 HepG2 cells homology Host host cell host range Human human coronavirus human coronaviruses Human immunodeficiency virus identification IFITM3 IFITMs immune Immunopathogenesis Including Infection influenza A virus inhibited knockdown LY6E lymphocyte mechanism modulate neutralized overexpression pandemic Pathogenesis Protein Proteins reported restriction factor SARS-CoV-2 serine protease TMPRSS2 significantly significantly higher significantly increased Spike protein susceptibility susceptible transmembrane Treatment variety viral entry virus virus entry viruses were expressed while [DOI] 10.1128/JVI.00562-20 PMC 바로가기 [Article Type] Virus-Cell Interactions
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19Review Published on 2020-07-052022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] affecting Antiviral apoptotic autophagy autophagy pathway canonical canonical autophagy cellular complex coronavirus Coronavirus replication Coronaviruses COVID-19 detrimental disease drug identify inducer Infection inhibitor innate immune responses Interaction knowledge margin modulation molecular molecular mechanism noncanonical autophagy other diseases pathway Potential potential therapeutic target previous study Protective Proteins recent SARS-CoV-2 SARS-CoV-2 pandemic Still target Treatment turn viral infections viral replication virus [DOI] 10.3390/cells9071619 PMC 바로가기 [Article Type] Review
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning역백신학 및 기계 학습을 사용한 COVID-19 코로나바이러스 백신 설계Immunology Published on 2020-07-032022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상, [키워드] adhesins Analysis antigenicity applied breath Candidates caused clinical trial complementary Complete conserved contagious contagious disease coronavirus coronavirus vaccine COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop disease effective Epitopes FIVE Host human coronavirus immune responses induce infecting Invasion lack linear B-cell epitope linear B-cell epitopes machine learning membrane MERS MERS-CoV MHC-I MHC-II mild symptoms N protein non-structural protein non-structural protein 3 non-structural proteins NSP Nsp3 NSP8 nucleocapsid predict predicted Protective Protein Proteins proteome reverse vaccinology S protein Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus sequence stimulate structural protein T-cell epitopes target tested the S protein the SARS-CoV-2 Vaccine vaccine candidate Vaccine development vaxign vaxign-ML Viral virus was selected [DOI] 10.3389/fimmu.2020.01581 PMC 바로가기 [Article Type] Immunology