Spatial, Temporal, and Functional Assessment of LC3-Dependent Autophagy in Shigella flexneri Dissemination시겔라 플렉스네리 확산에서 LC3 의존성 자가포식의 공간적, 시간적 및 기능적 평가Article Published on 2018-07-232024-08-22 Journal: Infection and Immunity [Category] 세균성이질, [키워드] acidification autophagosome autophagy dissemination Shigella flexneri vacuole.
Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent ResponsesCellular Response to Infection Published on 2018-02-282022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Ablation adaptive affected Antiviral Astrocyte astrocytes Cell Central nervous system CNS components contribute coronavirus Critical dissemination effective elevated elicit Encephalomyelitis evaluated expression function Gene Expression Glia histocompatibility complex IFN-α IFN-β IFN-α/β IFN-γ IFNAR immune Immunity inducer Infection infiltration initial Innate immunity Interaction interferon interferon-stimulated gene ISG ISGs lack lethal MHC MHV mice microglia Mortality mouse hepatitis virus mRNA mRNA level Neuron neurons pathway pattern recognition receptor promote PROTECT protection Protective PRRs receptor reduced Regulatory response responses robust Signaling Single Cell subsequent Support supported sustained T cell upregulated viral infection viral spread virus virus replication virus spread while [DOI] 10.1128/JVI.01901-17 PMC 바로가기 [Article Type] Cellular Response to Infection
Discovery and genetic analysis of novel coronaviruses in least horseshoe bats in southwestern ChinaOriginal Article Published on 2017-03-292022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis bat bat coronavirus bats Characteristics China collected country CoV CoVs described dissemination Evidence Evolution FIVE Genetic genetic analysis group least horseshoe bat Novel coronavirus nucleotides Open reading frame ORFs provided Recombination rectal swab reservoir Sample SARS-CoV SARS-CoVs SARS-like CoV Sequencing strain Urine virus viruses [DOI] 10.1038/emi.2016.140 PMC 바로가기 [Article Type] Original Article
A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3″)-II, is horizontally transferred among Acinetobacter spp. by homologous recombination고유 아미노글리코사이드 뉴클레오티딜트랜스퍼라제의 새로운 서브클래스인 ANT(3")-II는 상동 재조합에 의해 Acinetobacter spp. 사이에서 수평으로 전달됩니다.Research Article Published on 2017-02-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Acinetobacter Aminoglycoside Antibiotic resistance antibiotic resistance gene Author Bacterial capture clades conserved demonstrated disseminate dissemination Genes genes encoding genomic genomic region genus Homologous recombination hotspot insertion sequence insertion sequences intrinsic investigated lead mechanism MOST natural resistance Pathogens pathway Plasmid plasmids populations Prevalence provided resistance gene resistance genes species spectinomycin Spread streptomycin transferred variant [DOI] 10.1371/journal.pgen.1006602 PMC 바로가기 [Article Type] Research Article
Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profileArticle Published on 2016-11-232022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] accessory protein addition Analysis animal antigenicity bronchitis classical conducted coronavirus cross cross protection dissemination exhibited exhibiting experiment expression Gene expression profiling gene induction Genes Genome sequences Genotype homology Host Host immune response IBV identification Infectious Bronchitis Virus innate immune genes Innate immunity Local neutralization pathogenicity PCR prolonged viral shedding renal reveal Spike protein strain Strains subset Taiwan Vaccine virus wild-type [DOI] 10.1038/srep37725 PMC 바로가기 [Article Type] Article
Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickensResearch Article Published on 2016-07-132022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] Antigen Blood blood monocyte Cell cells demonstrated disseminate dissemination IBV in vitro in vivo Infectious Bronchitis Virus inoculated internal organ kidney kidney infection liver Lungs M41 mononuclear cell mucosa penetrate Peripheral blood plasma positive cell post inoculation Replication replication kinetics respiratory tract secretion spleen strain Trachea tracheal Viral RNA Viremia virus [DOI] 10.1186/s13567-016-0354-9 PMC 바로가기 [Article Type] Research Article
A Porcine Epidemic Diarrhea Virus Outbreak in One Geographic Region of the United States: Descriptive Epidemiology and Investigation of the Possibility of Airborne Virus SpreadResearch Article Published on 2015-12-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis ArcGIS collected Contact determine disease disease spread dissemination epidemic diarrhea evaluated Geographic highest Hypothesis incidence increased risk indicated Infection information investigation mechanisms outbreak pathogen positive potential mechanism predominant Randomly Region Research Spread suggested Support The United States Transmission virus were used [DOI] 10.1371/journal.pone.0144818 PMC 바로가기 [Article Type] Research Article
Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesisReview Published on 2015-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] affected animal models antagonistic antiviral cytokine Apoptosis autopsy study Brain cell interaction coronavirus dendritic cells dissemination Epidemic epithelial cells Ex vivo help Human human lung human macrophage human primary cell implication IMPROVE in vitro induce infect infection control Infectious virus lack mechanism MERS MERS patient MERS-CoV MERS-CoV infection Middle East multiple organ organ Pathogenesis productive viral replication proinflammatory public health replicate research finding respiratory respiratory epithelial cell respiratory syndrome coronavirus severe respiratory infection suggested Support susceptible T cell These cells tissue tropism tissues Treatment triggering Viral RNA virus [DOI] 10.1186/s12985-015-0446-6 PMC 바로가기 [Article Type] Review
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous SystemResearch Article Published on 2015-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while [DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article
Pathogenesis of Varicelloviruses in primatesArticle Published on 2014-10-012024-09-04 Journal: The Journal of pathology [Category] 대상포진, [키워드] dissemination Immunity latency non-human primates Primary infection Reactivation Humans Simian varicella virus Varicella-Zoster Virus [DOI] 10.1002/path.4451 PMC 바로가기 [Article Type] Article