Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary TrajectoriesResearch Article Published on 2020-06-242022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adaptive Amino acid amino acid change Analysis antiretroviral Antiviral APOBEC cause change comparable Complete consequence coronavirus COVID-19 curated Defense directional driven by Effect event Evidence Evolution Frequency G+C content Genome HCoV-NL63 Host host cell hosts human coronavirus hypermutation implication initial Intensive mechanism Middle East Molecular epidemiology motif Mutation Neutral normalized nucleotide occurred Occurrence Other other coronavirus pandemic proportion Proteins provide SARS SARS coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant sequence Spread substitutions syndrome virus widespread [DOI] 10.1128/mSphere.00408-20 PMC 바로가기 [Article Type] Research Article
E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulationResearch Published on 2020-06-182022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] ACE2 receptor affected BALF cellular collagen collected conducted determine dysregulated Dysregulated repair E-cig exposure ECM Effect Electronic cigarette Extracellular matrix female glycol Health induce Inflammation Inflammatory Inflammatory response less lung epithelial Lung inflammation lung tissue Macrophage male matrix metalloproteinase mechanism mice MMP12 MMP2 Mmp8 MMP9 mRNA transcript nAChRα7 occur phenotype pro-inflammatory cytokine Protein Proteins pulmonary inflammation receptor reduced Regulation Research SARS-CoV-2 significantly T-lymphocyte The United States Toxicity was increased wild-type [DOI] 10.1186/s12931-020-01396-y PMC 바로가기 [Article Type] Research
Neutrophil extracellular traps in COVID-19Research Article Published on 2020-06-042022-11-01 Journal: JCI Insight [Category] COVID-19, [키워드] absolute neutrophil count acute respiratory distress breathing room air C-reactive protein cell-free DNA chromatin circulating Cohort coronavirus disease correlated COVID-19 COVID-19 patient D-dimer determine elevated enzyme Extracellular extracellular trap Future hospitalized patient identify in vitro individuals with COVID-19 infections Infectious disease Inflammation lactate dehydrogenase lung marker mechanical ventilation Microvascular thrombosis NET NETs neutrophil Neutrophil extracellular trap Neutrophils Patient patients with COVID-19 Platelet predictive power Proteins reactants receiving regulated released Respiratory failure sera Severe case severe COVID-19 severe respiratory disease syndrome therapeutic target triggered Viral pneumonia Web [DOI] 10.1172/jci.insight.138999 PMC 바로가기 [Article Type] Research Article
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?Research Article Published on 2020-05-302022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] Analysis applied bat caused comparison coronavirus Coronaviruses correlated COVID-19 Cross-species transmission described difference envelope homologous isolate isolates pangolin predicted Protein Proteins related virus reported Respiratory Coronavirus SARS-CoV-2 similarity three-dimensional structure variant viral infection virus [DOI] 10.1155/2020/4389089 PMC 바로가기 [Article Type] Research Article
Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?Research Article Published on 2020-05-302022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] Analysis applied bat caused comparison coronavirus Coronaviruses correlated COVID-19 Cross-species transmission described difference envelope homologous isolate isolates pangolin predicted Protein Proteins related virus reported Respiratory Coronavirus SARS-CoV-2 similarity three-dimensional structure variant viral infection virus [DOI] 10.1155/2020/4389089 PMC 바로가기 [Article Type] Research Article
Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis of SARS-CoV-2-Related VirusesResearch Article Published on 2020-05-292022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alpha Analysis arising attenuate beta-coronavirus beta-CoV Combination comparable Complete coronavirus coronavirus disease CoV COVID-19 COVID-19 pandemic determinant domain Evolution evolutionary arms race Factor Genome Genomic analysis genomic region Health Host Host immune response host immunity hosts identify immune immune evasion immune pressure Immunoglobulin individual insight macro modulate MOST novel Novel coronavirus ORF1a ORF8 outbreak Pathogenesis pathogenicity predicted Protein Proteins Receptor binding domain Region SARS SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-like coronavirus scrutiny sequence severity Structural analysis the Spike Transmission unique virus Virus-host interactions viruses widespread [DOI] 10.1128/mBio.00760-20 PMC 바로가기 [Article Type] Research Article
Vulnerabilities in coronavirus glycan shields despite extensive glycosylationArticle Published on 2020-05-272022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Clusters complex coronavirus CoVs epitope Epitopes Fatality rate fusion protein glycan glycobiology glycoprotein Glycoproteins glycosylated glycosylation high-density HIV-1 HKU1 humoral immune response immune evasion immunogenic immunological influenza hemagglutinin MERS Middle East N-linked glycosylation Neutralizing pandemic Protein Proteins S protein shielding spike syndrome trimeric spike Viral immune evasion Viral protein viral spike virus glycoprotein vulnerability zoonotic pathogen [DOI] 10.1038/s41467-020-16567-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 strategically mimics proteolytic activation of human ENaCShort Report Published on 2020-05-262022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] ACE2 Activation acute respiratory distress syndrome adopted Affect airway Amino acid Analysis block cause Cell cell type cells cellular cleavage cleavage site cleave conditions coronavirus COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 patients Critical diagnose dysregulation ENaC enzyme epithelial explain expression global pandemic Health help highlight highlighting homeostasis Host host cell Human human cell human lung human proteins human respiratory cells identify identifying infect interfere lifecycle lung Lungs mechanism molecular mimicry mouse organ overlap pathophysiology patients peptide Prevent protease Protein Proteins proteolytic proteolytic activation receptor ACE2 remained respiratory tract respiratory tract cell resulting RNA-Seq S1/S2 cleavage site SARS-CoV-2 sequence sequenced severe respiratory symptoms sodium spike the SARS-CoV-2 the spike protein treat unique virus [DOI] 10.7554/eLife.58603 PMC 바로가기 [Article Type] Short Report
Human neutralizing antibodies elicited by SARS-CoV-2 infection Research Published on 2020-05-262022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Anti-RBD antibody anti-SARS-CoV-2 antibody antibody binding candidate caused cellular receptor coronavirus coronavirus disease COVID-19 cross-react cross-reactivity elicited entry of SARS-CoV-2 health emergency Human individual infected with SARS-CoV-2 inhibit inhibitors Intervention Isolation MERS-CoV Middle East monoclonal antibody neutralize neutralizing antibody pandemic plasma Proteins RBD SARS-CoV SARS-CoV-2 SARS-COV-2 infection single B cell steric hindrance target cell the RBD the receptor-binding domain trimeric spike viral entry viral spike protein [DOI] 10.1038/s41586-020-2380-z [Article Type] Research
The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19Article Published on 2020-05-232022-10-28 Journal: The protein journal [Category] COVID-19, SARS, [키워드] acute respiratory syndrome cause caused Coronavirus-2 COVID-19 death disease Effect global pandemic Protein Proteins respiratory SARS CoV-2 supplementary material virus [DOI] 10.1007/s10930-020-09901-4 PMC 바로가기 [Article Type] Article