immune responses – Page 76 – Communicable Diseases Research

Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils

호중구의 항바이러스 능력에 대한 I형 인터페론 매개 조절

Review

Published on 2021-04-292022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제,

Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera

초기 유행성 혈청에 의한 우려의 SARS-CoV-2 변종에 대한 중화의 상관 관계

Pathogenesis and Immunity

Published on 2021-04-282022-09-10
Journal: Journal of Virology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] antibodies B.1.1.7 B.1.351 B.1.351 variant binding characterized clinical feature Cohort concern convalescent COVID-19 convalescent patient COVID-19 pandemic Critical cross-neutralization effective Evidence exacerbate homologous immune responses Immunity immunological Increasing Infection investigated mechanism Mutation N-terminal domain nAb response NAb responses NAb titers natural immunity natural infection neutralization Neutralizing antibodies neutralizing antibody NTD overcome pandemic primary mechanism promote RBD Receptor binding domain reduced reduction in response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly spike gene stimulated subjects susceptibility T cell T cell responses T cells These data Vaccine-induced immunity Vaccines variant variants Virological
[DOI] 10.1128/JVI.00404-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry

COVID-19 감염으로 입원한 환자의 염증 마커의 성별 차이: MGH COVID-19 환자 레지스트리의 통찰력

Research Article

Published on 2021-04-282022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 바이오마커,

[키워드] 95% CI Activation age Analysis association baseline Better Clinical outcome clinical outcomes contribute COVID-19 infection COVID-19 patient CRP death disease severity evidenced examined exhibited Exploratory analyses ferritin General Hospital greater higher risk Hospitalized ICU admission IL-6 immune activation immune response immune responses Infection Inflammatory Inflammatory marker inflammatory markers initial insight Interaction Linear regression model Massachusetts General Hospital men men and women multivariable logistic regression outcome pathophysiology patients hospitalized PCT peak inflammatory Result robust serious complication Sex Sex difference Study design systemic inflammation were used with COVID-19 women
[DOI] 10.1371/journal.pone.0250774 PMC 바로가기 [Article Type] Research Article

Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

조절되지 않는 선천 및 적응 면역 반응이 COVID-19의 질병 중증도를 구별합니다

Article

Published on 2021-04-232022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커,

[키워드] abrogated adaptive Adaptive immunity Analysis Biomarkers Cell Clustering analysis COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients Critical Critically ill critically ill patients cytokine cytokine production Cytokines disease disease severity exhaustion markers flow cytometry hepatocyte growth factor highlight highlighting host response Hyperinflammatory immune response immune responses Inflammatory Inflammatory responses Innate innate immune innate immune response innate immune responses Innate immunity interferon interferon-γ interleukin interleukin-17 lymphopenia mononuclear cell performed Peripheral blood Plasma cytokine Potential biomarker potential biomarkers proinflammatory proteomics provide response Result stem cell stem cell factor T-cell exhaustion Variation Whole blood
[DOI] 10.1093/infdis/jiab065 PMC 바로가기 [Article Type] Article

Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes

SARS-CoV-2 백신 투여 요법의 역학 및 진화적 고려 사항

Research Article

Published on 2021-04-232022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단,

[키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Affect antigenic evolution approach approved assumption available dose available doses build building can be used Characteristics clinical evaluation Combination condition consequence continuous spectrum coronavirus country COVID-19 infection COVID-19 infections Critical decrease dependent on determine disease severity distribution dose dosing regimen effective vaccine effort elicited epidemiological equity Evolution example first dose highlight immune Immune escape immune response immune responses Immunity immunized Impact imperative improves in some increase increase in individual individual immunity individuals Infection infections International Intervention long term medium middle mitigate mutations natural immunity Numerous outcome outcomes pandemic parameters phylodynamic population immunity Primary infection problems proportion public policies question rationale receiving reduce reduced replicate respiratory resulting robustness Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 viral Science second dose secondary infections serological data severe acute respiratory syndrome Coronavirus short term single dose single vaccine Spread strength Stress subsequent susceptibility susceptible switching the timing the vaccine trajectory vaccinal vaccination vaccination rate vaccination rates Vaccine vaccine dose Vaccines variants Variation variations Viral viral adaptation viral antigenic evolution Viral load viral loads virus
[DOI] 10.1126/science.abg8663 PMC 바로가기 [Article Type] Research Article

Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial

코로나바이러스 질병 2019 사망률과 관련된 조기 질병 궤적을 결정하기 위한 면역 프로파일링: ACTT-1 시험의 하위 연구

Article

Published on 2021-04-232022-09-11
Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료제,

[키워드] ACTT-1 acute respiratory syndrome acute respiratory syndrome coronavirus 2 affected antibody Antibody Response Antibody responses antiviral therapy Clustering coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine response death disease trajectories dominant early disease enrolled Hierarchical hierarchical clustering Hospitalized Host immune response host immune responses immune responses investigated neutralization occurred outcome participant Placebo Profiling Randomized Remdesivir respiratory serology seronegative serum severe acute respiratory syndrome Coronavirus specimen study enrollment study participant symptom onset trajectory Treatment with COVID-19
[DOI] 10.1093/infdis/jiab035 PMC 바로가기 [Article Type] Article

The Use of the Anticoagulant Heparin and Corticosteroid Dexamethasone as Prominent Treatments for COVID-19

Medicine

Published on 2021-04-232022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] ACE2 Administered administration Alter Anti-inflammatory anti-inflammatory drug anti-SARS-CoV-2 Anti-viral Anticoagulant Antithrombotic applicability approach ARDS binding Blood complement Complication Corticosteroid COVID-19 COVID-19 disease severity COVID-19 severity Cytokine storm death case death rate Deleterious derivatives detrimental Dexamethasone diabetics disease downregulation drug early stage ENhance Evidence exacerbated feasible fibrinolytic global healthcare glucocorticoid glucocorticoid dexamethasone groups heparin highlight hyperglycemia hypertensive patients IL-6 immune responses impairing Inflammation initial Invasive mechanical ventilation LTB medical condition modulate Mounting Occurrence Patient presenting Prominent Protein reduce required respiratory risk SARS-CoV-2 secretion severe COVID-19 patients severe patients significantly sodium spike standard treatment therapy Treatment upregulated viral clearance viral infection viral infectivity
[DOI] 10.3389/fmed.2021.615333 PMC 바로가기 [Article Type] Medicine

Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts

정성 및 정량 판독이 가능한 단일 희석 COVID-19 항체 검사

Research Article

Published on 2021-04-212022-09-10
Journal: mSphere [Category] MERS, SARS, 진단, 치료기술,

[키워드] Accuracy active infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptability antibody Antibody test Asymptomatic blood sample caused Community coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient detect detection determine effort ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay equipment estimation global pandemic Health care health care systems Health Policies help IgA IgA antibodies IgA antibody IgG IgG titer IgG titers immune response immune responses individual immune response Laboratory laboratory diagnostic test Molecular tests overcome Patient Patient care Prevalence protective antibodies Protective antibody public health Qualitative Quantitative quantitative test reagent respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein sensitivity Sensitivity and specificity Seroconversion serological surveillance Serological testing serology serology test serology tests severe acute respiratory syndrome Coronavirus specificity spike glycoprotein Spike protein spike-specific IgG strength Surveillance Test the SARS-CoV-2 vaccination Viral viral spike
[DOI] 10.1128/mSphere.00224-21 PMC 바로가기 [Article Type] Research Article

Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19

Gut Homing Marker α4β7 Integrin을 발현하는 순환 적응 면역 세포는 COVID-19에서 감소합니다

Immunology

Published on 2021-04-202022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive B cell cause characterized circulating contribute convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Decreased epithelial cells expressing expression flow cytometry Frequency Gastrointestinal symptom gastrointestinal symptoms Gut gut homing healthy control healthy controls homing IgA IgA-expressing Immune cell immune cells immune responses immune system integrin Integrins intestinal intestinal epithelial cell intestinal epithelial cells Lymphocytes Manifestations marker memory T Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes priming recruited respiratory Result SARS-CoV-2 SARS-COV-2 infection Symptom systemic immune response systemic immune responses T cell trafficking target these cell These cells tissue virus was reduced while wide range of symptoms
[DOI] 10.3389/fimmu.2021.639329 PMC 바로가기 [Article Type] Immunology

Type I Interferon Production of Plasmacytoid Dendritic Cells under Control

Review

Published on 2021-04-182022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,