Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 PatientsResearch Article Published on 2021-01-222022-10-27 Journal: BioMed Research International [Category] [키워드] Analysis analyzed B cell Cell cell counts cells collected correlated COVID-19 Cytokine storm death death in COVID-19 Deceased decrease feature helper T cells Hyperinflammatory IL-10 IL-6 IL-8 independent predictor indicated induce Inflammatory cytokine lymphocyte Lymphocyte subset Lymphocyte subsets lymphopenia multivariate NK cell objective outcome Patient patients peripheral predict remained Result Retrospective study ROC Curve SARS-CoV-2 significantly subset survival survivor Survivors T cell T cells Tongji Hospital with COVID-19 Wuhan, China [DOI] 10.1155/2021/9101082 PMC 바로가기 [Article Type] Research Article
Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 PatientsResearch Article Published on 2021-01-222022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Analysis analyzed B cell Cell cell counts cells collected correlated COVID-19 Cytokine storm death death in COVID-19 Deceased decrease feature helper T cells Hyperinflammatory IL-10 IL-6 IL-8 independent predictor indicated induce Inflammatory cytokine lymphocyte Lymphocyte subset Lymphocyte subsets lymphopenia multivariate NK cell objective outcome Patient patients peripheral predict remained Result Retrospective study ROC Curve SARS-CoV-2 significantly subset survival survivor Survivors T cell T cells Tongji Hospital with COVID-19 Wuhan, China [DOI] 10.1155/2021/9101082 PMC 바로가기 [Article Type] Research Article
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cellsResearch Articles Published on 2021-01-212022-10-28 Journal: Science Immunology [Category] COVID-19, [키워드] Analysis anti-apoptotic CD8 Cell COVID-19 patient cytotoxicity disease dominant enrichment feature Frequency Glycolysis healthy control healthy subject healthy subjects Inflammatory Influenza memory Mild molecular NF-κB signaling Pathways Patient reactive respiratory syncytial virus respond response robust SARS-CoV-2 SARS-COV-2 infection severe COVID-19 illness severe disease single-cell single-cell transcriptome subset T cell T cell memory T cell response T cells transcript two group [DOI] 10.1126/sciimmunol.abe4782 PMC 바로가기 [Article Type] Research Articles
Bacterial-Derived Outer Membrane Vesicles are Potent Adjuvants that Drive Humoral and Cellular Immune ResponsesArticle Published on 2021-01-202024-09-02 Journal: Pharmaceutics [Category] 대상포진, [키워드] adjuvants B cells dendritic cells OMVs T cells [DOI] 10.3390/pharmaceutics13020131 PMC 바로가기 [Article Type] Article
In silico dynamics of COVID-19 phenotypes for optimizing clinical management임상 관리 최적화를 위한 COVID-19 표현형의 인 실리코 역학Biological Sciences Published on 2021-01-192022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] 유전자 메커니즘, [키워드] ACE2 activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response adaptive immune responses age Antiviral baseline best CD8 cellular entry Clinical data clinical heterogeneity Clinical management Clinical outcome clinical outcomes Coagulation coagulation cascade Combination Comorbidities Comorbidity coronavirus COVID-19 COVID-19 patients COVID-19 phenotype COVID-19 progression Cytokines diabetes Disease progression distinctive feature dysregulated immune response element elements Evolution extreme Factors framework Health status healthy heterogeneity hypertension identify immune immune cells immune responses Infection Inflammatory cytokines innate immune response life life threatening management mathematical mathematical model mechanism Model modulating obesity Older Older age outcome oxygen oxygen saturation Patient pharmaceutical intervention predict presence of comorbidities protocols provide Renin response rate reveal risk factor SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus Significance Simulation sustained symptomatic T cell T cells the disease the patient therapeutic Therapies thrombosis Thrombus thrombus formation Trajectories Treatment Treatment response understanding Viral viral dynamics Viral load viral replication virus were used [DOI] 10.1073/pnas.2021642118 PMC 바로가기 [Article Type] Biological Sciences
Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19Research Article Published on 2021-01-182022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] Admission B cell Care CD4 CD8 changes in collected comparable COVID-19 COVID-19 patient Critical Critical case critical cases cytokine level Cytokine storm death decrease disease pathogenesis disease severity dynamic Dynamic changes effective hospital Hospitalization Host immune response IL-10 IL-6 illness onset increase in Inflammatory cytokine investigated knowledge lack Lymphocyte subset Lymphocyte subsets Lymphocytes moderate negative correlation NK cells nonsurvivor Pathogenesis Patient Peripheral blood poor prognosis Proinflammatory cytokine Result SARS-CoV-2 SARS-COV-2 infection severe disease severe group significantly significantly higher sustained T cell T cells T lymphocytes with COVID-19 Wuhan [DOI] 10.1186/s12879-021-05792-7 PMC 바로가기 [Article Type] Research Article
Disease‐duration based comparison of subsets of immune cells in SARS CoV‐2 infected patients presenting with mild or severe symptoms identifies prognostic markers for severity경증 또는 중증 증상을 나타내는 SARS CoV-2 감염 환자의 면역 세포 하위 집합의 질병 기간 기반 비교는 중증도에 대한 예후 마커를 식별합니다.Comparative Study Published on 2021-01-162022-09-12 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, [키워드] absence adaptive adaptive immune cells Adaptive immunity addition Analysis analyzed Antibody titer association B cells CD8 T cells Cell dendritic cells determined by disease disease severity event expression flow cytometry follicular forms Frequency functional healthy subject help Humoral immunity Hyperactivation identification identify IgG IL‐6 Imbalance Immune cell immune cells Immune profile India indicated infected patient Infection innate immune cell Innate immune cells Lower lymphocyte Lymphocytes management material maturation mDC mDCs memory B cell memory B cells Mild modulation Monocytes Multivariate analysis Neutralizing antibody titer neutralizing antibody titers NK cells observation Older age pandemic Pathogenesis Patient patient cohort patients positive presenting PRNT PRNT50 Prognostic marker Prognostic markers receptor Result SARS CoV‐2 SARS‐CoV‐2 SARS‑CoV2 Severe case severe cases severe disease severe symptom severity Spectrum subset Symptoms T cell T cells T helper cells therapy understanding [DOI] 10.1002/iid3.402 PMC 바로가기 [Article Type] Comparative Study
Placental pathology of the third trimester pregnant women from COVID-19Case Report Published on 2021-01-142022-11-01 Journal: Diagnostic Pathology [Category] COVID-19, [키워드] 2019 novel coronavirus acute respiratory syndrome B cell cells Clinical characteristics Clinical management CoV COVID-19 cured demonstrated disease double staining eight evaluated Evidence Fluorescence gestation Hofbauer cells hybridization immunofluorescence immunohistochemistry Infection inflammatory cell information Macrophage monoclonal antibody outcome pathological change pathology Patient Placenta Placenta pathology placental Plasma cell Pregnancy pregnant women probe provided RNA SARS-CoV-2 spike protein SARS-CoV-2 virus serological evidence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly increased Syncytial knots T cells The third trimester pregnancy tissue Transmission transmission of SARS-CoV-2 Vascular women [DOI] 10.1186/s13000-021-01067-6 PMC 바로가기 [Article Type] Case Report
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice개코원숭이에서의 SARS-CoV-2 스파이크 당단백질 백신 후보 NVX-CoV2373 면역원성 및 마우스에서의 보호Article Published on 2021-01-142022-09-12 Journal: Nature Communications [Category] 비임상, 진단, [키워드] angiotensin anti-S antibody anti-S IgG antibody Antigen Antigen-specific T cells B cell binding block CD4 CD8 clinical evaluation COVID-19 pandemic elicit elicited enzyme Evidence evidence of follicular full-length full-length spike protein functional Germinal center hACE2 hACE2 receptor helper T cell high affinity human Angiotensin-converting enzyme immunogenic immunogenicity low-dose Matrix-M mice multifunctional neutralize no evidence of NVX-CoV2373 prefusion conformation PROTECT Protective Protein Protein binding Protein vaccines receptor respiratory Respiratory disease S-protein Safe Saponin SARS-CoV-2 SARS-CoV-2 spike glycoprotein Spike protein spleen Spread subunit Subunit vaccine Support T cells Tfh Vaccine vaccine candidate virus virus infection [DOI] 10.1038/s41467-020-20653-8 PMC 바로가기 [Article Type] Article
Overall reduced lymphocyte especially T and B subsets closely related to the poor prognosis and the disease severity in severe patients with COVID-19 and diabetes mellitusResearch Published on 2021-01-122022-10-31 Journal: Diabetology & Metabolic Syndrome [Category] COVID-19, [키워드] age baseline Characteristics Chinese clinical clinician Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 group COVID-19 patient COVID-19 patients Diabetes Mellitus disease Disease progression disease severity dysregulated healthy control Host immune response immunomodulatory IMPROVE lowest lymphocyte Lymphocyte count Lymphocyte subset Lymphocyte subsets Lymphocytes Patient patients with COVID-19 peripheral lymphocyte poor prognosis Prevalence Prognosis reduced Result severe COVID-19 severe disease Severe patient severity significantly subset T cells the disease to define Treatment with COVID-19 [DOI] 10.1186/s13098-020-00622-3 PMC 바로가기 [Article Type] Research