Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccinationmRNA 백신 접종 후 SARS-CoV-2 미경험 및 회복된 개인에서 뚜렷한 항체 및 기억 B 세포 반응Research Articles Published on 2021-04-152022-09-10 Journal: Science Immunology [Category] MERS, SARS, 변종, 진단, [키워드] addition age analyses antibodies antibody Antigen antigen-specific memory B cells B cells B.1.351 B.1.351 variant Cell cellular cellular response Cellular responses circulating antibodies clinical trials correlated COVID-19 declined demonstrated detectable distribution dose Efficacy Emergency use full-length spike protein highlight immune responses increases in individual individuals memory memory B memory B cell memory B cells mRNA mRNA vaccination mRNA vaccine mRNA vaccines naïve naïve individual Neutralizing titer neutralizing titers no increase novel priming RBD recall Receptor binding domain required response responses robust SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2 vaccine second dose serological serology significantly single vaccine Spike protein Spike receptor binding domain subject subjects titers utility Vaccine vaccine dose vaccine-induced immune response [DOI] 10.1126/sciimmunol.abi6950 PMC 바로가기 [Article Type] Research Articles
Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19Molecular Biosciences Published on 2021-04-152022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] absence acute respiratory syndrome Ad5-nCoV antigenic protein approaches candidate ChAdOx1-S clinical development computational tool coronavirus COVID-19 COVID-19 vaccine Critical curtail develop development developmental DNA and RNA drug Ebola virus evaluated feature Genetic globe healthcare host cell immune responses inactivated Incubation period indication induce landscape MERS-CoV Novel coronavirus nucleic acid outbreak pandemic peptides platform Potential Prevalence recombinant proteins Research SARS-CoV-2 sequence the disease the vaccine Vaccine vaccine antigen vaccine candidates Vaccines vector vectors Viral vector Viral vector vaccine virus virus-like particles viruses World Health Organization zoonotic [DOI] 10.3389/fmolb.2021.635337 PMC 바로가기 [Article Type] Molecular Biosciences
Differentially expressed immune response genes in COVID-19 patients based on disease severity질병 중증도에 따라 COVID-19 환자에서 차등적으로 발현되는 면역 반응 유전자Research Paper Published on 2021-04-152022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antiviral antiviral genes APOBEC3G Apolipoprotein Apolipoprotein B appear blood sample Blood samples case-control study catalytic changes in chemokine chemokines city collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL10 CXCL11 CXCL9 cytokine Cytokines death decreased expression disease Disease progression disease severity domain downregulated dysregulated immune response dysregulated immune responses enzyme expressed FADD Gene Expression genes encoding healthy control healthy controls healthy subject Host IFN IFNA1 IFNA2 IFNAR1 IL12A IL12B IL15 IL1B IL6 Illness severity immune response gene immune response genes immune responses induction IRF7 ISG15 microRNA mRNA MX1 Patient patients PCR progression Proinflammatory cytokine proinflammatory cytokines Protein recovered COVID-19 patient recruited respiratory RNA extraction SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Signaling significantly thought TLR8 TLR9 type I interferon underlie upregulated [DOI] 10.18632/aging.202877 PMC 바로가기 [Article Type] Research Paper
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome급성 호흡 곤란 증후군이 있는 중환자 COVID-19 환자의 IFN-I 활성 및 면역 프로파일에 대한 종단 평가Clinical Trial Published on 2021-04-122022-08-13 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome alteration appear ARDS ARDS patient ARDS patients Bacterial sepsis cellular COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine cytokine levels Cytokines decrease described Elevation expression followed by Hospital stay ICU admission IFN response IFN-I IFN-stimulated gene IFN-stimulated genes IFNα2 immune immune parameter Immune profile immune response immune responses immuno-inflammatory Immunosuppression intensity ISG longitudinal longitudinal immune monitoring lymphocyte Lymphocyte count marker mHLA-DR non-survivor normal values Occurrence outcome pandemic plasma question respiratory distress Result SARS-CoV2 infection Secondary infection secondary infections Sepsis similarities similarity supplementary material Survivors syndrome TNF-α Type-I IFN [DOI] 10.1186/s13054-021-03558-w PMC 바로가기 [Article Type] Clinical Trial
The role of CD4 + FoxP3 + regulatory T cells in the immunopathogenesis of COVID-19: implications for treatmentCOVID-19의 면역 병인 발생에서 CD4 + FoxP3 + 조절 T 세포의 역할: 치료에 대한 의미Review Published on 2021-04-102022-08-31 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 바이오마커, [키워드] “cytokine storm” acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus adalimumab addressed Antiviral ARDS attenuation Azithromycin CD4 CD4+FoxP3+ regulatory T cells Chloroquine Coagulopathy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine release syndrome Cytokine storm Defense deficiencies deficiency Dexamethasone early stage FOXP3 Hydroxychloroquine IL-2 immune Immune homeostasis immune response immune responses Immunopathogenesis immunopathology implication Infection Inflammatory responses introduced involved late stage low dose maintenance mechanisms organ damage organ injury Patient Perspective problem problems Regulatory Regulatory T cell regulatory T cells respiratory respiratory distress Respiratory distress syndrome sarilumab SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases syndrome T cell T cells tetrandrine therapeutic agent therapeutic agents Therapies Tocilizumab transfer Treatment Treg Treg cell Treg cells Tregs Vitamin D [DOI] 10.7150/ijbs.59534 PMC 바로가기 [Article Type] Review
The Genetic Variant of SARS-CoV-2: would It Matter for Controlling the Devastating Pandemic?SARS-CoV-2의 유전적 변종: 치명적인 전염병을 통제하는 것이 중요할까요?Review Published on 2021-04-102022-09-10 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 변종, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody neutralization caused Cluster controlling coronavirus COVID-19 D614G Efficacy effort elicited evade Evidence FIVE Genetic variant genetic variants herd immunity highlight immune response immune responses Infection matter Mutation N-terminal domain notable P.1 pandemic of COVID-19 Pathogenesis raised respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein vaccination Vaccine vaccine efficacy Vaccines variant virus virus transmission VOC 202012/01 widespread [DOI] 10.7150/ijbs.59137 PMC 바로가기 [Article Type] Review
Strategies for Immunomonitoring after Vaccination and during InfectionReview Published on 2021-04-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adaptive immune response approach approaches Conventional Course COVID-19 COVID-19 pandemic Diseases effector Efficacy example help hypotheses immune immune mechanism immune response immune responses immunomonitoring include Infection knowledge question raise Strategy Systems biology Toxicity vaccination Vaccine viral control [DOI] 10.3390/vaccines9040365 PMC 바로가기 [Article Type] Review
IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individualsSARS-CoV-2에 대한 IL-33 발현은 COVID-19 회복기 개인의 혈청 양성과 상관관계가 있습니다Article Published on 2021-04-092022-09-12 Journal: Nature Communications [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age anti-SARS-CoV-2 antibody anti-Spike IgG Antibody titer Asthma BALF Bronchoalveolar lavage fluid CD14 CD4 Cell cells chronic disease Chronic diseases Cohort convalescent convalescent individual convalescent individuals COPD coronavirus COVID-19 COVID-19 pathogenesis days post-infection disease severity Effect elicit Epidemiology expression Fever glycoprotein IFNA2 IL-1β IL-23 IL-33 IL-6 immune immune response immune responses Immunity increase Infection Interleukins Mild Monocytes observational study Pathogenesis Patient PBMC PBMCs PCR peptide produced Pulmonary infection recall reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein scRNAseq seronegative seropositive seropositive individuals Seropositivity Seropositivity for SARS-CoV-2 Seroprevalence severe acute respiratory syndrome Coronavirus severe COVID-19 spike spike glycoprotein spike IgG subject subset Symptoms T cell T cell activation the disease their family member their family members TLR7 TNF virus [DOI] 10.1038/s41467-021-22449-w PMC 바로가기 [Article Type] Article
Durability of Immunity to SARS-CoV-2 and Other Respiratory VirusesReview Published on 2021-04-082023-06-15 Journal: Trends in microbiology [Category] MERS, SARS, [키워드] COVID-19 immune responses Immunity Infection respiratory viruses SARS-CoV-2 [DOI] 10.1016/j.tim.2021.03.016 PMC 바로가기 [Article Type] Review
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19높은 처리량, 단일 사본 시퀀싱은 급성 COVID-19 동안 체액 면역 증가와 일치하는 SARS-CoV-2 스파이크 변이체를 보여줍니다Clinical Trial Published on 2021-04-082022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Analysis Antibody binding Antiviral antiviral drug antiviral therapies antiviral therapy applied approach arising autologous antibodies binding Cell culture clearance Clinical outcome Clustering contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cross-sectional analysis detect detectable domain epitope evade Evolution exhibit Frame furin furin cleavage site Genetic genetic diversity Genome genomic RNA Haplotype help Humoral immunity immune response immune responses Immune-mediated in vitro in vivo increase in independent individual individuals with COVID-19 infected individual infected individuals infecting initial intra-individual longitudinal analysis Mutation mutations Non-synonymous mutation NTD one individual participant Pathogenesis predominant regions respiratory reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 replication SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant SARS-CoV-2 variants selected selection of variant sequence Sequencing sequencing technology serum serum sample Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein study participant surface protein surface proteins susceptibility the SARS-CoV-2 Time frame upper respiratory sample variant variants Variation virion virus virus RNA virus variants viruses WA-1 reference with COVID-19 [DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial