Cell adhesion as a novel approach to determining the cellular binding motif on the severe acute respiratory syndrome coronavirus spike proteinArticle Published on 2014-02-132022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome against SARS-CoV Amino acid analyses approach binding Binding motif binding site caused Cell cellular coronavirus spike protein determine Effect H7N9 Influenza life threatening MERS-CoV Middle East motif MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide pathogen peptide Peptide inhibitor Psychological RBD, receptor-binding domain RBM, receptor-binding motif required residues respiratory syndrome coronavirus S, spike Safe SARS-CoV SARS-CoV spike protein SARS-CoV, severe acute respiratory syndrome-coronavirus Spike protein synthetic peptide the spike protein Therapeutic approach vaccine candidate VERO E6 cells [DOI] 10.1016/j.jviromet.2014.01.022 PMC 바로가기 [Article Type] Article
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry비만의 유전자 × 신체 활동 상호 작용: 유럽 조상 111,421명의 통합 분석Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity Adult Adults age aggregate effect allele analyses analysis Analysis ancestry attenuate Author BMI calculated Characteristics Cohort cohorts Combined cumulative cumulative effect detected diminishe environmental exposure European Europeans Evidence evidence of examined FTO gene × environment interactions genetic risk genetic risk score Genetic variant Genome-wide association studies genotyped GRS heterogeneity Inclusion indicated individual inefficient inhibit Interaction interaction effect interactions knowledge Li linear loci locus logistic regression model meta-analyses meta-analysis Meta-analysis multicenter Multiplicative interaction Multiplicative interactions North North America nucleotide Numerous obesity Participants physical activity provide Questionnaires replicated Replication reported Sample size SEC16B Secondary analyses Sex single nucleotide polymorphisms SNP SNP × physical activity interactions statistically significant Support tested treated variant [DOI] 10.1371/journal.pgen.1003607 PMC 바로가기 [Article Type] Research Article
Identifying SARS-CoV Membrane Protein Amino Acid Residues Linked to Virus-Like Particle AssemblyResearch Article Published on 2013-05-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid acute respiratory syndrome addition affected Amino acid amino acid residue analyses analysis Analysis assembly codon coexpressed Combined conserved coronavirus Critical cysteine residue ectodomain endodomain identify identifying Interaction involved membrane motif mutant Mutation nucleocapsid Particle Protein reduced reduction in regions required residue Result SARS-CoV SARS-CoV virus secretion sequence Serine severe significantly Substitution transmembrane vesicles virus Virus-like particle VLP VLPs [DOI] 10.1371/journal.pone.0064013 PMC 바로가기 [Article Type] Research Article
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human PrimatesResearch Article Published on 2010-02-052022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome advanced age age analyses analysis anti-inflammatory action ARDS Author cause Comprehensive contributed coronavirus correlated develop different differential expression diminishe disease displaying exacerbated expression Gene genomic H5N1 host response IFN-β IL-8 in viral increase in individual individuals Infection Inflammation influenza A Innate Intervention life-threatening Lungs macaque macaques Microarray modulation molecular mRNA level NF-κB outcome pandemic pathogen Pathogenesis pathology Pathways Patient primate pro-inflammatory gene expression Protective provide reduce reduced Replication response reveal SARS-CoV SARS-CoV infection severe severe pathology severity shown significantly significantly more syndrome Treatment type I Type I IFN type I interferon viral infection viral replication viral respiratory virus infection virus replication without affecting [DOI] 10.1371/journal.ppat.1000756 PMC 바로가기 [Article Type] Research Article
Improved microarray gene expression profiling of virus-infected cells after removal of viral RNAMethodology Article Published on 2008-05-142022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Accuracy acquisition alteration analyses conditions coronavirus detect different False-positive Gene Expression Gene expression profiling host cell IMPROVE Improved infected cell Infection interfere investigated mean Microarray microarray analysis Microarrays reduced reliability Result RNA RNAs sensitivity significantly tested total RNA Viral RNA virus-infected cell vRNA [DOI] 10.1186/1471-2164-9-221 PMC 바로가기 [Article Type] Methodology Article