Identification and characterization of a Golgi retention signal in feline coronavirus accessory protein 7bResearch Article Published on 2017-08-312022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, MERS, [키워드] accessory protein addition approach C-terminal C-terminus cause cells cellular cellular trafficking changes in cleavage site Control coronavirus coronavirus accessory proteins Effect Endoplasmic reticulum expressing expression Feline coronavirus Feline infectious peritonitis FIVE FLAG-tagged form functions Genetic glycosylation Golgi Golgi retention identification information investigated motif mutant N-terminal predicted processed Protein Proteins provide purified recombinant residues resulting retained retention signal reverse genetics secretion sequence Sequence analysis Substitution virus [DOI] 10.1099/jgv.0.000879 PMC 바로가기 [Article Type] Research Article
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibodyResearch Article Published on 2017-08-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied acute respiratory disease antibody Asymptomatic case asymptomatic infection Betacoronavirus Clinical signs complement confirmed case Contact tracing deaths develop dose-dependent elicited enhanced Human implication increase in individual Infection Inflammation Inflammatory response inoculated intranasal Lung disease Lung inflammation lung lobe MERS-CoV Middle East Mild naïve Neutralizing activity neutralizing antibody Neutralizing antibody response Neutralizing antibody titer New non-neutralizing antibody occur perivascular inflammation Primary infection PROTECT Protein Proteins Pulmonary infection pulmonary inflammation recruitment Reinfection reported respiratory syndrome coronavirus risk serum subsequent transfer Viral antigen viral challenge Viral protein Viral RNA waned while zoonotic [DOI] 10.1371/journal.ppat.1006565 PMC 바로가기 [Article Type] Research Article
The nucleoid occlusion protein SlmA is a direct transcriptional activator of chitobiose utilization in Vibrio choleraenucleoid occlusion protein SlmA는 Vibrio cholerae에서 키토비오스 활용의 직접적인 전사 활성제입니다.Research Article Published on 2017-07-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activity addition aquatic environment bind Catabolism cause Cell cell division ChiS chitin chitobiose cholera cholerae composed Critical disaccharide disease disparate disrupt downstream drinking water Evolution expression function Gene regulation gene transfer horizontal gene Horizontal gene transfer identify implicated in vivo Interaction involved locus mechanism member mutant pathogen persistence Point mutation point mutations promoter Protein Proteins regulated Regulation regulator required TetR the marine transcriptional transcriptional activation transcriptional regulator transfer transposon utilization Vibrio cholerae water [DOI] 10.1371/journal.pgen.1006877 PMC 바로가기 [Article Type] Research Article
Crystal structure of Middle East respiratory syndrome coronavirus helicaseResearch Article Published on 2017-06-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis arterivirus C-terminal caused component conserved coronavirus CoV crystal structure domain domains drug design effective eukaryotic Fatality rate full-length Helicase information Interaction membrane MERS-CoV Middle East N-terminal nidoviruses nonstructural protein nsp13 Nsps Pandemics Protein Proteins public health remained replication-transcription complex respiratory syndrome coronavirus SARS-CoV SF1 targets Vaccine viral RNA synthesis while [DOI] 10.1371/journal.ppat.1006474 PMC 바로가기 [Article Type] Research Article
Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor초파리의 기능성 남성 액세서리 땀샘과 생식력에는 새로운 엑디손 수용체가 필요합니다Research Article Published on 2017-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Nuclear Receptors) analyzed Behavior Biodiversity carried cause cell death cells Critical Depletion dominant negative downstream Drosophila Drosophila melanogaster dying cells Ecdysone examined females Fertility forms Health hormone hormone receptor hormone receptors include independent insect Insects isoform male male fertility male reproductive system males management mechanism of action molecular Nuclear receptors pest control Physiology Protein protein synthesis Proteins receptor receptors regulated Regulation reproduction reproductive reproductive system secretory tissue Seminal fluid sterility tissue transcription factor transcription factors transfer [DOI] 10.1371/journal.pgen.1006788 PMC 바로가기 [Article Type] Research Article
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domainsArticle Published on 2017-04-102022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] Analysis cell entry coronavirus Cryo-electron microscopy determine flexible fusion peptide high-resolution structure HKU1 host cells host tropism MERS-CoV MHV Neutralizing antibodies NL63 other coronavirus pathogenic coronavirus pre-fusion Protein Proteins RBD receptor Receptor binding Receptor binding domain reported SARS-CoV SARS-CoV S protein Sequence conservation spike glycoprotein Structure target the RBD trimeric virus [DOI] 10.1038/ncomms15092 PMC 바로가기 [Article Type] Article
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease심혈관 질환의 83개 혈장 단백질 바이오마커에 대한 79개 유전자좌 매핑Research Article Published on 2017-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Analysis approach association associations Author automated Biomarker Blood blood concentration bystander can be used cardiovascular disease cause Cell classic Combination Concentration Coronary artery Coronary artery disease correlation CVD determine disease Epidemiology eQTL evaluate Evidence evidence of expression expression quantitative trait loci Genetic genetic regulation Genetic variant genetic variants genome-wide association genome-wide significant genotyping GWA higher risk highlight human disease identify implicated individual individuals information involved knowledge large cohort leads Ligand loci majority manual curation mapping matrix metalloproteinase mechanism multiplexed immunoassay novel offer plasma plasma protein plasma proteins Protein protein expression protein level protein levels Proteins provide Quantitative RANK recent regulate Regulation Regulatory replicated risk Risk factors stem cell stem cell factor targets text mining the disease turn upstream validation study variant [DOI] 10.1371/journal.pgen.1006706 PMC 바로가기 [Article Type] Research Article
Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [ PSI + ] prion formation피질의 액틴 세포골격을 교란하는 것은 효모 [PSI + ] 프리온 형성의 두 가지 뚜렷한 메커니즘을 나타냅니다.Research Article Published on 2017-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate abrogated Actin affected Affinity purification aggregate aggregates aggregation Analysis antioxidant component composed conditions cortical Deletion disease disrupt examined form forms fragmentation Frequency fungal identify implicated increase infectious agent infectious agents insoluble protein mass spectrometry mechanism misfolded protein misfolded proteins molecular MOST mutant mutants neurodegenerative occur overexpression oxidative oxidative damage oxidative stress oxidized Prevent Previous studies previous study prion Probability Protein Protein misfolding Proteins PSI reduced required thought transition translation Trigger undergo yeast yeast cell yeast cells [DOI] 10.1371/journal.pgen.1006708 PMC 바로가기 [Article Type] Research Article
An Overview of Structural Features of Antibacterial Glycoconjugate Vaccines That Influence Their Immunogenicity항균 글리코접합 백신의 면역원성에 영향을 미치는 구조적 특징 개요Article Published on 2017-03-282024-08-24 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] 폐렴구균 감염증, [키워드] carbohydrates conjugation Glycoconjugates Proteins spacer
X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug designArticle Published on 2017-01-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activity catalytic catalytic function cellular changes in core coronavirus Critical domain drug design Efficiency enzyme Enzymes evaluate Hypothesis in viral in vitro Infection inhibitor interferon MERS N-terminal N-terminus no difference Papain-like protease platform PLPro polyprotein polyproteins profile protease Proteins Regulation required specificity stability Structure substrate thermal stability utility was determined while X-ray [DOI] 10.1038/srep40292 PMC 바로가기 [Article Type] Article