Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19Immunology Published on 2020-12-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] AKT Alter Apoptosis CD4+ CD8+ CD8+ T cells cell death COVID-19 cytotoxic function death differentiation disease course Exhaustion FAS hallmark immune response infected cells lymphocyte lymphopenia mechanism Migration pathway Severe case severe COVID-19 disease T cell T cell lymphopenia T cell proliferation T cells T-cells [DOI] 10.3389/fimmu.2020.600405 PMC 바로가기 [Article Type] Immunology
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 대한 적응 면역 반응 연구를 위해 쥐에서 mRNA 유도 인간 안지오텐신 전환 효소 2 발현Research Article Published on 2020-12-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model Antigen Antiviral Author caused CD4+ CD4+ T cell CD8+ CD8+ T cell cells cloned coronavirus Critical demonstrated Efficacy entry of SARS-CoV-2 Epitopes expressed expression functional hACE2 hACE2 receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human coronavirus humans immune response in vivo induce Infection information interferon receptor Laboratory lack membrane Membrane proteins memory mice mRNA mRNA expression mRNA transfection mRNA-based murine murine model murine models nucleocapsid pandemic peptide peptide epitope peptides preserved provided receptor Replication required respiratory response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis Secondary infection severe acute respiratory syndrome Coronavirus Spike proteins strain T cell T cell epitope T cell epitopes T cell response T cells this system type 1 interferon unique Vaccine vaccine efficacy Vaccines virus [DOI] 10.1371/journal.ppat.1009163 PMC 바로가기 [Article Type] Research Article
Dynamic SARS-CoV-2-Specific Immunity in Critically Ill Patients With Hypertension고혈압이 있는 중환자의 동적 SARS-CoV-2-특이적 면역Immunology Published on 2020-12-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] absence Activation acute respiratory syndrome Antibody Response caused CD38 CD4 CD8 Cellular responses Chronic illness clinical coronavirus coronavirus disease correlated COVID-19 COVID-19 patient Critical critical cases dynamic dysregulation exhibited expression finding Health HLA-DR hypertension hypertensive patient IFNγ IgA IgG IgM Ill immunological characteristics infected with SARS-CoV-2 Infection low expression lymphopenia onset of symptoms outbreak outcome Patient Prolonged SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 viral load severe COVID-19 severe disease severe SARS-CoV-2 significantly surviving patients T cell T cells the patient titers of IgG Viral load were measured [DOI] 10.3389/fimmu.2020.596684 PMC 바로가기 [Article Type] Immunology
CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention유전적으로 다양한 인간 집단에서 지속적으로 돌연변이를 일으키는 SARS-CoV-2 스파이크 단백질을 향한 CD8 T 세포 에피토프 생성: 질병 통제 및 예방에 대한 시사점Research Article Published on 2020-12-102022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence Affect Algorithm allele Analysis anti-S anti-SARS-CoV-2 immune response anti-SARS-CoV-2 immune responses B cell B cells CD8 T cell CD8 T cells collected CoV Critical cross-reactive D614G disease Effect epitope Epitopes genetic background Health care Health care system health care systems HLA HLA allele HLA alleles HLA-A HLA-B immune responses Immunity indicated individual isolate life Mutation mutations pandemic Point mutation predicted Protein reported S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 spike protein sequence Spike protein suggested T cell T cells the SARS-CoV-2 understanding Vaccine design Viral viral evolution [DOI] 10.1371/journal.pone.0239566 PMC 바로가기 [Article Type] Research Article
Biomodulina T (InmunyVital ® ) Restores T Cells and Helps Contain COVID-19Immunology Published on 2020-12-092022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Biomodulina T COVID-19 immunomodulator immunosenescence Immunotherapy InmunyVital T cells vaccine enhancer [DOI] 10.3389/fimmu.2020.606447 PMC 바로가기 [Article Type] Immunology
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cellsCD147-스파이크 단백질은 SARS-CoV-2가 숙주 세포에 감염되는 새로운 경로입니다Article Published on 2020-12-042022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] ACE2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-CD147 antibody BEAS-2B BHK-21 cells binding CD147 cell line COVID-19 COVID-19 patient deficiency detectable disease dose-dependent manner effective effective drug endocytosis enzyme Evolution of SARS-CoV-2 expressed expressing Extracellular facilitate host cell host cell receptor host cells Human Industrial microbiology infected with SARS-CoV-2 Infection inhibit inhibited Interaction intestine kidney lung lung tissue Lungs lymphocyte Lymphocytes Meplazumab mice neutralized property Protein provide pseudovirus receptor reported reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 spike protein Spike protein T cell T cells today Vero E6 Viral viral loads virion virions virus virus entry virus infection wild type [DOI] 10.1038/s41392-020-00426-x PMC 바로가기 [Article Type] Article
The characteristics and outcomes of 681 severe cases with COVID-19 in China중국 코로나19 중증환자 681명의 특징과 결과Article Published on 2020-12-012022-09-11 Journal: Journal of critical care [Category] 바이오마커, [키워드] ACEi ACEi/ARB Admission Arbidol AUC blockers C-reactive protein cardiovascular cardiovascular disease CD3 Characteristics China clinical Clinical characteristics collected Combination confirmed case confirmed cases COVID-19 COVID-19 patient COVID-19 patients CRP death died effective enrolled epidemiological feature Laboratory Lactate lactate dehydrogenase LDH lymphocyte male median age Mortality myocardial injury neutrophil Neutrophil-to-lymphocyte ratio NLR on admission outcome Patient predicted Predictive Protective Ratio ribavirin SARS-CoV-2 Severe case severe COVID-19 severe COVID-19 patient severe COVID-19 patients study participant Study participants survival T cell T cells therapeutic Treatment treatments with COVID-19 β-blocker β-blockers [DOI] 10.1016/j.jcrc.2020.07.003 PMC 바로가기 [Article Type] Article
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2감기 코로나바이러스와 SARS-CoV-2에 대한 건강한 기증자 T 세포 반응Clinical Trial Published on 2020-12-012022-09-11 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, 치료기술, 치료법, 치료제, [키워드] 229E acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Cell characterized circulating common cold common cold coronavirus common cold Coronaviruses coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture determine Donor donors ELISPOT ELISpot assay enzyme enzyme-linked immunospot exposure to had no HCoV HCoV-229E HCoV-NL63 HCoV-OC43 healthy donor Immunity immunology in vitro Infectious disease influence memory T memory T cell NL63 Novel coronavirus nucleocapsid protein Nucleocapsid proteins OC43 outcomes peptide peptide pool peptide pools peptides Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seronegative severe acute respiratory syndrome Coronavirus Spike protein Spike proteins suggested T cell T cell response T cell responses T cells the spike protein virus [DOI] 10.1172/JCI143120 PMC 바로가기 [Article Type] Clinical Trial
Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up입원 중 사용한 약물과 3개월 추적관찰 중 코로나19 환자의 면역학적 변화의 연관성Article Published on 2020-12-012022-09-11 Journal: International immunopharmacology [Category] MERS, SARS, 진단, 치료제, [키워드] antibiotic use association CD3+ CD4+ CD4+ T cell CD4+ T cells CD8+ T cells changes in China completion COVID-19 COVID-19 patient COVID-19 patients declined decrease demonstrated discharge enrolled evaluate Follow-up glucocorticoid herd immunity Hospitalization IgG IgG and IgM IgM Immunity immunoglobulins immunological change immunological changes Immunological response immunological responses Increases increases in IQR Linear regressions median medication medications men Patient patients with COVID-19 positive rate positive rates Regression retrospective cohort study screened significantly increased T cell T cells understanding Vaccine was performed were used Wilcoxon signed-rank test with COVID-19 women [DOI] 10.1016/j.intimp.2020.107121 PMC 바로가기 [Article Type] Article
Specific dynamic variations in the peripheral blood lymphocyte subsets in COVID-19 and severe influenza A patients: a retrospective observational studyCOVID-19 및 중증 인플루엔자 A 환자의 말초 혈액 림프구 하위 집합의 특정 동적 변화: 후향적 관찰 연구Observational Study Published on 2020-12-012022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] (T cells Affect alteration Blood donors CD4 CD8 change Clinical significance Comorbidities contribute Coronavirus disease-19 (COVID-19) COVID-19 determine different time point different time points Disease progression early infection examined Flow cytometric analysis four group four groups healthy blood donors healthy controls healthy donor healthy donors hospital immune mechanism increased mortality Influenza influenza A leukocytes lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Patient patients’ data performed Peripheral blood Prognosis Result retrospective severe COVID-19 Severe influenza A significantly lower Specific stages supplementary material T cell T cells T cells subsets the patient turn Variation [DOI] 10.1186/s12879-020-05637-9 PMC 바로가기 [Article Type] Observational Study