Therapeutic efficacy, mechanical ventilation, length of hospital stay, and mortality rate in severe COVID-19 patients treated with tocilizumab토실리주맙으로 치료받은 중증 COVID-19 환자의 치료 효능, 기계적 환기, 입원 기간 및 사망률Article Published on 2021-06-012022-09-12 Journal: International journal of clinical practice [Category] SARS, 진단, [키워드] 24 hour acute respiratory distress addition approved ARDS baseline baseline levels carried clinical parameter correlation COVID-19 COVID-19 disease CRP death dose Efficacy ferritin FIVE hospital Hospital stay hospitalisation ICU IL 6 IL-6 IL-6 inhibitor improvement IQR Laboratory laboratory parameter Laboratory parameters LDH main role management mechanical ventilation median Ministry of Health moderate Mortality mortality rate outcome Patient patients died Prospective protocol receiving reducing reduction reflected repeated required Safe serum Severe case severe COVID-19 Severe COVID-19 Infection severe COVID-19 patient severe COVID-19 patients significantly lower single dose syndrome TCZ therapeutic therapeutic effect therapeutic efficacy therapy Tocilizumab tocilizumab administration treated Treatment were assessed [DOI] 10.1111/ijcp.14079 PMC 바로가기 [Article Type] Article
Comparison of Clinical Characteristics and End-of-Life Care Between COVID-19 and Non-COVID-19 Muslim Patients During the 2020 PandemicCovid-19 Published on 2021-05-272022-10-28 Journal: The American Journal of Hospice & Palliative Care [Category] Coronavirus, SARS, [키워드] 24 hour baseline blood draw Care changed clinical Clinical characteristics Cohort Coronavirus disease 2019 COVID COVID patient COVID-19 COVID-19 patient death died DNAR eligible end-of-life family member High dose hospital Hospitalization ICU in both group limitation mechanical ventilation Muslim occurred Palliative care pandemic Patient patients proportion required Terminal disease Therapies therapy vasopressors Withdrawal [DOI] 10.1177/10499091211018657 PMC 바로가기 [Article Type] Covid-19
Comparing Lung CT in COVID-19 Pneumonia and Acute Heart Failure: An Imaging ConundrumCardiology Published on 2021-05-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour Acute heart failure Admission analyzed Characteristics Chest CT chest CT scan clinical collected Computed tomography consolidation coronavirus disease COVID-19 disease distribution effective enrolled evaluate favor feature GGOs groups heart heart failure hospitalized patient imaging individual interlobular interstitial tissue lesion low-dose Lung CT Major morphology overlap overlapping parenchymal Patient Pneumonia provide Pulmonary edema recorded report Result Retrospective analysis statistical two group with COVID-19 [DOI] 10.7759/cureus.15120 PMC 바로가기 [Article Type] Cardiology
Hypoxia induces expression of angiotensin‐converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID‐19Original Article Published on 2021-05-152022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] 24 hour ACE2 ACE2 expression ACE2 mRNA acute lung injury acute respiratory distress AEC airway epithelial cell alveolar alveolar epithelial cell alveolar epithelial cells ARDS binding Cell Characteristics Course COVID‐19 Critical Culture dependent on develop distal enzyme II epithelial experiment expression facilitate Features FiO2 host cell surface host serine protease hypoxia hypoxic hypoxic environment in vitro in vivo increase in increased expression induce Isolation lung lung epithelial cell mechanism mice mRNA murine murine model normoxia Pathogenesis Patient progression Protein protein expression proteolytic cleavage purified reduced SARS‐CoV‐2 significantly increased Spike protein Stress subset syndrome TMPRSS2 type I viral spike protein [DOI] 10.14814/phy2.14854 PMC 바로가기 [Article Type] Original Article
Study protocol of the Edinburgh and Lothian Virus Intervention Study in Kids: a randomised controlled trial of hypertonic saline nose drops in children with upper respiratory tract infections (ELVIS Kids)어린이에 대한 에딘버러 및 로시안 바이러스 중재 연구의 연구 프로토콜: 상부 호흡기 감염이 있는 어린이의 고장성 식염수 점비제에 대한 무작위 대조 시험(ELVIS Kids)Article Published on 2021-05-052022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 24 hour 24 hours 48 hour 48 hours age All participant All participants approved asked Asymptomatic board Care Child child health children chloride clinical Community community child health Complete Contact control arm Controlled trial determine Edinburgh Ethics events Health hypertonic hypertonic saline immunisation Infection Infectious disease Intervention intervention arm Local media nasal swab National Health Service neonatology nose drop nose drops nostril office Open-label paediatric infectious disease & Participation partnership peer-reviewed primary care protocol provided questionnaire randomised randomised controlled trial recruited recruitment registration number Research Research Ethics satisfaction questionnaire service Sodium chloride standard care Symptom symptomatic university upper respiratory tract upper respiratory tract infection URTI URTI symptom URTI symptoms Virology website West wheeze [DOI] 10.1136/bmjopen-2021-049964 PMC 바로가기 [Article Type] Article
Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trialClinical Trial Published on 2021-05-012022-10-05 Journal: Stem cells translational medicine [Category] SARS, 임상, 진단, [키워드] 1:1 24 hour acute respiratory distress AEs analyzed anti-inflammatory effect ARDS Cell cell transplantation cellular cellular therapy clinical trials Control control group COVID-19 cytokine death determine distress double-blind Effect Efficacy Endpoint event group groups high mortality immunomodulatory improved patient survival intention to treat intravenous infusion mesenchymal stem cell Mesenchymal stem cells patient survival Randomized Randomized controlled trial randomized, controlled trial respiratory tract SAEs Safe secondary Serious Adverse Event severity significantly Standard of care stem cell Stratification subject survival syndrome Time to recovery transplantation Treatment treatment group UC-MSC umbilical Umbilical cord was performed was used with COVID-19 [DOI] 10.1002/sctm.20-0472 PMC 바로가기 [Article Type] Clinical Trial
Natural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trialCOVID-19 환자를 위한 천연 탄닌 추출물 보충제(TanCOVID): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-282022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 1:1 24 hour 24 hours addition Administered administration affected age All trial participants all-cause mortality Alpha alpha error Antibiotic therapy antipyretics assigned assisted ventilation Azithromycin B12 blinded Blinding branch Buenos Aire Buenos Aires can not Chestnut tannins Clinical symptoms clinical trial closure cognitive computer-generated random numbering conditions Consent control group COVID-19 COVID-19 patient criteria cytokine Cytokines Day Decline decrease defined Definition Department described diagnosis of SARS-CoV-2 dietary supplement difference disease dissemination dose double-blind Efficacy element eligibility eligible enrolled Enrollment enrolment epidemiological evaluate excluded fecal Final first dose first visit Gender gut microbiota Hospital de Clínica Hospital de Clínicas Hospital de Clinicas Jose de San Martin hospital discharge Hydroxychloroquine hypersensitivity ICU impaired consciousness increase in indicated Infection Infectious disease Infectious diseases Inflammation inflammatory mediator Inflammatory mediators Informed consent intestinal intestinal permeability invasive ventilation lactating Level Lopinavir mean difference measure mechanical ventilation mediators microbiota modifications molecular natural non-invasive ventilation number objective Older outcome parallel-group parameter participant Participation Patient patients per day Placebo placebo-controlled platform Potential power power of 80% protocol Quebracho tannins randomization Randomized Randomized controlled trial Randomly Real-time PCR receive recruited recruitment Registered Research Ritonavir Sample size SARS-COV-2 infection SARS-CoV2 screened secondary secondary outcome measures severity Standard therapy standard treatment status study participant Study protocol study randomization submitted supplementary material supply tannin tannins therapy time Time frame took place Treatment treatment allocation Trial trial participant Trial registration undergo university Ventilation website [DOI] 10.1186/s13063-021-05281-x PMC 바로가기 [Article Type] Letter
Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report중증 코로나19 폐렴 산모에게서 태어난 수직감염 의심 미숙아의 임상 경과, 방사선 소견 및 후기 예후: 증례 보고Case Reports Published on 2021-04-232022-09-12 Journal: Journal of Medical Case Reports [Category] MERS, 진단, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age amniotic Amniotic fluid Birth Case report Chain Reaction clinical Clinical course complications coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 pneumonia died disease severity early-onset Infant infection with SARS-CoV-2 morbidity Mortality mother Neonatal Neonate newborn infant outcome PCR assay Pharyngeal swab polymerase chain polymerase chain reaction positive result pregnant women Preterm infant radiological finding Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR assay SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 Severe COVID-19 pneumonia Transmission vertical transmission [DOI] 10.1186/s13256-021-02835-0 PMC 바로가기 [Article Type] Case Reports
Simulated Identification of Silent COVID-19 Infections Among Children and Estimated Future Infection Rates With Vaccination예방 접종으로 어린이의 침묵하는 COVID-19 감염의 시뮬레이션된 식별 및 예상 미래 감염률Research Published on 2021-04-232022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 치료기술, 치료제, [키워드] 24 hour 24 hours absence addition Adults age analyzed approach asymptomatic stage attack rate attack rates benefit children Combination combinations comparable Course Coverage COVID-19 COVID-19 infection COVID-19 infections COVID-19 transmission COVID-19 vaccination disease disease transmission driver Effect effective Efficacy estimate Estimated exposure finding Future General population group identification identify Importance Infection infection rate infections Intervention Isolation less measure mitigate objective occur Older outbreak participant Point presymptomatic proportion Rate reduced reducing Relevance remained Reproduction number Result robust Sensitivity analyses sensitivity analysis setting severe COVID-19 significantly silent silent infection silent infections speed suppress susceptibility symptom onset symptomatic symptomatic case symptomatic cases synergistic synergistic effect Transmission unlikely vaccination Vaccine vaccine availability vaccine efficacy [DOI] 10.1001/jamanetworkopen.2021.7097 PMC 바로가기 [Article Type] Research
Preventing COVID-19 spread in closed facilities by regular testing of employees—An efficient intervention in long-term care facilities and prisons?Research Article Published on 2021-04-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 24 hour accelerated adjusted age approved benefit Care conditions Contact contribute counterproductive COVID-19 COVID-19 pandemic death diagnostic tests Disease prevalence Effect effective Effects Frequency Germany good quality group Immunity individual inefficient Infection infections Intervention introduced investigated measure Measures mitigate Older pandemic Preventing PROTECT Protective public health authorities reducing reduction reduction in Regular risk Spread suggested Testing the disease the WHO WHO [DOI] 10.1371/journal.pone.0249588 PMC 바로가기 [Article Type] Research Article