Alanine – Page 8 – Communicable Diseases Research

Elevated Liver Biochemistries in Hospitalized Chinese Patients With Severe COVID-19: Systematic Review and Meta-analysis

중증 COVID-19로 입원한 중국 환자의 간 생화학 증가: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-04-012022-09-11
Journal: Hepatology (Baltimore, Md.) [Category] MERS, SARS, 바이오마커,

Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19

간 손상은 COVID-19 환자의 불리한 임상 결과와 독립적으로 연관되어 있습니다

Article

Published on 2021-04-012022-09-11
Journal: Gut [Category] SARS, 치료제,

[키워드] 95% CI acute respiratory syndrome adjusted Admission admitted to ICU age Alanine alanine aminotransferase albumin ALT/AST aspartate Aspartate aminotransferase AST Beta Biochemistry cholestasis Clinical outcome coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database death defined diabete diabetes Diagnosis died HCoV HCoVs Hepatitis Hong Kong human coronavirus hypertension ICU Injury intensive care intensive care unit interferon interferon beta Invasive mechanical ventilation limit liver Liver function Liver function test Liver injury Lopinavir Lopinavir-ritonavir men occurred Patient patients patients with COVID-19 primary end point retrospective cohort study ribavirin Ritonavir SARS patient SARS patients Severe acute respiratory syndrome Virological
[DOI] 10.1136/gutjnl-2020-321726 PMC 바로가기 [Article Type] Article

Coronavirus disease 2019 and dengue: two case reports

Case Report

Published on 2021-03-262022-10-30
Journal: Journal of Medical Case Reports [Category] COVID-19, SARS,

[키워드] Acute respiratory infection acute respiratory syndrome administration affected Alanine Asian aspartate Atypical Care Case report caution clinician Coinfection Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Dengue dengue virus described develop Diagnosis diagnostics differential diagnosis diligence disease elevated Endemic expression False positivity febrile form Healthcare system hospital illness increasingly Infection intravenous fluid Laboratory leukopenia Maldives male management outcome pandemic Patient polymerase chain positive protocol Pulmonary edema regions report resource reverse transcription serology Symptom the disease transaminitis Transcription tropical was done
[DOI] 10.1186/s13256-021-02707-7 PMC 바로가기 [Article Type] Case Report

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19

COVID-19로 입원한 환자에서 렘데시비르 치료를 받은 경우와 없는 경우의 임상 개선 시간 비교

Research

Published on 2021-03-242022-09-10
Journal: JAMA Network Open [Category] SARS, 치료제,

[키워드] 28-day mortality 95% CI acute respiratory syndrome addition adjusted hazard ratio Administered administration Admission Admissions adults hospitalized age Alanine alanine aminotransferase albumin Analysis Baltimore blood cell blood pressure body mass body mass index C-reactive protein Chain Reaction Charlson Comorbidity Index clinical Clinical improvement clinical trial Cohort Combination Comorbidity Complete conducted Control controls coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid corticosteroid treatment Corticosteroids covariate COVID-19 death deaths decrease did not reduce dimerized Dimerized plasmin fragment D Effectiveness exposure faster filtration rate finding fraction glomerular filtration rate hazard ratio Health Organization health system hospital hospital discharge hospitalized patient hospitalized patients Importance improvement individual individuals infected individual infected individuals Infection interquartile range lymphocyte Lymphocyte count matched controls measure median median age men Mortality mortality rate multicenter objective outcome oxygen oxygen saturation participant Patient patients patients hospitalized Peripheral blood Point polymerase chain polymerase chain reaction Population Primary outcome Propensity score proportion pulse receipt receive recipient reduced Relevance Remdesivir Research respiratory respiratory rate Result retrospective secondary outcome setting severity Sex statistically significant temperature the median Therapies time treated Treatment Washington White blood cell with COVID-19 World Health Organization
[DOI] 10.1001/jamanetworkopen.2021.3071 PMC 바로가기 [Article Type] Research

The Age-AST-D Dimer (AAD) Regression Model Predicts Severe COVID-19 Disease

Research Article

Published on 2021-03-232022-10-31
Journal: Disease Markers [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Admission age Alanine ALT applied Aspartate aminotransferase AST biochemical Clinical course clinical phenotype collected condition COVID-19 COVID-19 patient COVID-19 patients D-dimer derivation dimer disease Factor high risk hospital ICU ICU admission ICU patient ICU Patients identify IMPROVE intensive care lactic dehydrogenase LDH life-threatening Linear regression Liver injury management marker Mild Model Multiple non-ICU non-ICU patients outcome Patient patients patients with COVID-19 predict predicted Predictive Probability Regression Result risk risk factor sensitivity seriously ill patient severe disease severity specificity suggested the disease validation
[DOI] 10.1155/2021/6658270 PMC 바로가기 [Article Type] Research Article

A High Percentage of Patients Recovered From COVID-19 but Discharged With Abnormal Liver Function Tests

Physiology

Published on 2021-03-172022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] Abnormalities abnormality Admission age Alanine alkaline phosphatase analyzed Aspartate aminotransferase change China clinical collected coronavirus Coronavirus disease 2019 correlated COVID-19 COVID-19 patient diagnosed with COVID-19 discharge Features function Health Hospitalization hospitalized patient hypertension incidence independent risk factor laboratory parameter limit liver Liver function Liver function test liver function tests Lymphocyte count no statistical difference non-severe cases oxygenation index pandemic Patient patients patients with COVID-19 percentage prevalent recovered regression analysis reported Result retrospective risk factor SARS-CoV-2 Severe case severe COVID-19 significantly higher Test the patient total bilirubin Treatment
[DOI] 10.3389/fphys.2021.642922 PMC 바로가기 [Article Type] Physiology

Coronavirus Disease Clinical and Laboratory Parameters: Dismembering the Values Reveals Outcomes

Internal Medicine

Published on 2021-03-052022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] 95% confidence interval Admission Affect age Alanine ALT Analysis Blood C-reactive protein calculated CBC clinical comorbid conditions complete blood count complications conducted corpuscular correlated country COVID-19 COVID-19 patient COVID-19 patients CRP curtail laboratory testing in covid-19 patients D-dimer data entry Descriptive statistics diagnosed with COVID-19 disease disease severity drugs Effect eight enrolled Factor ferritin level Fisher Gender hospital Hospital stay Hypotension hypoxia IBM information Inpatient Laboratory laboratory investigation Laboratory testing lactate dehydrogenase LDH Length medication men Mortality MOST multiple comorbidity not affect novel coronavirus disease objective Observational cohort study observé Older outcome outcome predictors in covid-19 outcomes oxygen saturation P-value parameter Patient patient age patients patients with COVID-19 performed Platelet polymerase chain positive provided Quantitative data ranged repeated Result serial laboratory testing in covid -19 severe disease severity significantly SPSS statistical statistically significant Statistics study participant study period survived Symptom treated trends of laboratory values in covid-19 USA value variable Version virus Volume windows
[DOI] 10.7759/cureus.13720 PMC 바로가기 [Article Type] Internal Medicine

Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients

코로나19 환자에서 로피나비르/리토나비르의 집단 약동학

Article

Published on 2021-03-012022-09-11
Journal: European Journal of Clinical Pharmacology [Category] 치료제,

[키워드] 50% effective concentration age Alanine alanine aminotransferase ALT Analysis aspartate Aspartate aminotransferase AST BMI body mass body mass index body weight C reactive protein Concentration concentrations coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 creatinine CRP data set described develop dose effective estimate females Final Gender Height high variability hospitalized patient interval Lopinavir Lopinavir/ritonavir males median mixed-effects modeling parameter Patient patients pharmacokinetic pharmacokinetics PK parameters plasma concentration Population proportion reduce regimen Ritonavir SARS-CoV-2 virus significant effect Steady state tested Vero E6 Vero E6 cell VERO E6 cells was tested
[DOI] 10.1007/s00228-020-03020-w PMC 바로가기 [Article Type] Article

Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases

코로나19 관련 간 손상의 임상적 특징과 위험인자 및 기능: 830건의 후향적 분석

Article

Published on 2021-03-012022-09-11
Journal: Annals of hepatology [Category] MERS, SARS, 바이오마커,

[키워드] 95% confidence interval abnormality Admission aims Alanine Alanine transaminase ALT Analysis aspartate Aspartate transaminase AST AST/ALT Betacoronavirus Biochemistry C-reactive protein C-reactive protein (CRP Causality change clinical Clinical features Cohort comparison Computed tomography COVID-19 patients CRP level CRP levels demographic determine Diagnostic Criteria drug Drug induced liver injury elevated exhibited Factor feature groups hepatic Hepatic insufficiency hospitalized COVID-19 patient hospitalized COVID-19 patients incidence information Laboratory testing liver Liver injury lymphocyte multivariable logistic regression Multivariable regression Odds ratio on admission outcome parameter Patient performed Pneumonia potential risk proportion ranged Retrospective analysis risk factor Risk factors tomography Triglyceride was used were used X-ray
[DOI] 10.1016/j.aohep.2020.09.011 PMC 바로가기 [Article Type] Article

Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance

입원 시 실험실 결과를 사용한 COVID-19 심각도 예측: 유익한 값, 임계값, ML 모델 성능

Article

Published on 2021-02-262022-08-31
Journal: BMJ Open [Category] MERS, 바이오마커,

[키워드] 95% CI activated activated partial thromboplastin time admitted to ICU Alanine alanine aminotransferase Algorithm aPTT aspartate Aspartate aminotransferase AUC Bilirubin Biochemistry bioinformatics Biomarker Biotechnology biotechnology & C reactive protein Clinical use comparable consecutive patient COVID-19 COVID-19 severity creatine creatine kinase CRP cut-off cut-off threshold D-dimer dataset Deterioration disease severity disproportion Dubai Features ferritin fibrinogen Free ICU identify Infectious diseases information information technology intensive care intensive care unit Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lymphocyte Lymphocyte count ML model non-severe cases online tool partial thromboplastin time Patient PCR predict prediction Predictive Prognosis prognosis of patient respiratory respiratory infections returned risk Stratification study cohort subjects threshold threshold value thresholds THROMBOPLASTIN total bilirubin troponin with COVID-19 worsening
[DOI] 10.1136/bmjopen-2020-044500 PMC 바로가기 [Article Type] Article