SARS-CoV-2 anti-spike antibodies after vaccination in pediatric heart transplantation: A first report소아 심장 이식에서 백신 접종 후 SARS-CoV-2 안티 스파이크 항체: 첫 번째 보고Article Published on 2022-02-012022-09-11 Journal: The Journal of heart and lung transplantation : th [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence anti-spike antibody anti-spike IgG antibodies antibody Antibody Response Antibody testing children Complete detectable diabetes Diabetes Mellitus IgG IgG antibody median median age myocarditis neutropenia Patient paucity of data pediatric pediatric heart transplant. Pediatric patient Post-vaccine pre-vaccination proportion recipient rituximab SARS-CoV-2 SARS-CoV-2 anti-spike IgG SARS-CoV-2 vaccination SARS-CoV-2 viral infection solid organ solid organ transplant Support the antibody response the SARS-CoV-2 vaccination Viral viral infection was performed [DOI] 10.1016/j.healun.2021.11.001 PMC 바로가기 [Article Type] Article
Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group건강한 인구집단에서 CoronaVac 28일 일정 예방접종으로 유도된 면역 반응 평가Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, 진단, [키워드] administration Analysis anti-spike antibodies anti-spike antibody Cell cellular Cellular immune response cellular immune responses CoronaVac COVID-19 Effectiveness ELISPOT evaluate granzyme granzyme B group herd immunity Hospitalization humoral immune response IFN-gamma immune memory immune response immune responses immunization Immunological memory increase in induce induced life memory Negative PCR Neutralizing Neutralizing antibodies Population recruited response robust SARS-CoV-2 SARS-CoV-2 spike protein schedule Science Sinovac Spike protein vaccination schedule Vaccine Volunteer [DOI] 10.3389/fimmu.2021.766278 PMC 바로가기 [Article Type] Immunology
Variability in detection of SARS-CoV-2-specific antibody responses following mild infection: a prospective multicentre cross-sectional study, London, United Kingdom, 17 April to 17 July 2020경증 감염 후 SARS-CoV-2 특이적 항체 반응 검출의 가변성: 전향적 다기관 횡단 연구, 영국 런던, 2020년 4월 17일~7월 17일Multicenter Study Published on 2022-01-272022-09-10 Journal: Eurosurveillance [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 95% confidence interval Adults age Anosmia anti-RBD Anti-RBD IgG anti-RBD IgG antibodies anti-RBD IgG antibody anti-receptor-binding domain anti-spike antibodies anti-spike antibody antibody Antibody Response Asymptomatic Asymptomatic disease binding confidence interval coronavirus correlated correlation cough COVID-19 cross-sectional cross-sectional study diagnostics expressed Fever IgG IgG antibodies immunoassay immunoassays Linear regression London majority Mild multicentre multivariate neutralising observé PCR-confirmed raise RBD IgG reactivity reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody Seroconversion serum sample Sex significantly specific antibodies symptom onset symptomatic symptomatic individuals Symptomatology tested United Kingdom Variability was performed [DOI] 10.2807/1560-7917.ES.2022.27.4.2002076 PMC 바로가기 [Article Type] Multicenter Study
Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein스파이크 당단백질에 대한 항체 반응의 도메인 특이성과 상대적 효능에서 SARS-CoV-2 감염 개인 간의 제한된 변이Research Article Published on 2022-01-262022-09-12 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity analyzed anti-spike antibodies anti-spike antibody antibodies antibody Antibody neutralization Antibody Response Antibody responses antiviral activity caused characterized collected composed convalescent convalescent-phase plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine defined domain domains Efficacy elicit elicited exhibited fixed form generate immunoassay immunoglobulins individual infected individual Limited MOST N-terminal domain neutralization neutralization potency neutralize Neutralizing activity Neutralizing antibodies NTD pandemic plasma samples polyclonal potency produced Protective pseudovirus quantity RBD Receptor-binding domain Region relative replication-competent SARS-CoV-2 response Sample SARS-CoV-2 SARS-CoV-2 spike serum serum and plasma Seven severe acute respiratory syndrome Coronavirus specificity spike glycoprotein Spike protein subject subjects subunit subunits tested the antibodies the antibody the antibody response the RBD the receptor-binding domain the Spike the spike protein trimer vaccinated individual Variability Variation virus while [DOI] 10.1128/spectrum.02676-21 PMC 바로가기 [Article Type] Research Article
Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age rangesCOVID-19 BNT162b2/Comirnaty 백신에 대한 항체 반응에 대한 모집단 균질성은 모든 성인 연령 범위에 걸쳐 2차 접종 후에만 도달됩니다.Article Published on 2022-01-102022-09-12 Journal: Nature Communications [Category] 진단, 치료기술, [키워드] age anti-spike antibody BNT162b2 Care Cohort COVID-19 COVID-19 pandemic dose effort Epidemiology explained heterogeneity heterogeneous homogeneity hospital hospital care humoral immune response Humoral immunity IgA IgG IgM immunogenicity Immunosuppressed increasing age induce Inter-individual variation mRNA vaccine mRNA vaccines nursing home Population population level reached reduced required SARS-CoV-2 spike protein second dose Seroconversion serological Sex single vaccine Spike protein spike-specific IgG the antibody response vaccination Vaccine vaccine dose vaccinees viral infection while [DOI] 10.1038/s41467-021-27761-z PMC 바로가기 [Article Type] Article
Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assaysSARS-CoV-2 환자 혈장에서 스파이크 방지 항체의 친화성과 COVID-19 항체 분석에 미치는 영향Article Published on 2022-01-012022-09-12 Journal: EBioMedicine [Category] SARS, 진단, [키워드] Abbott Laboratories Abbott Laboratory Affect affinity Affinity maturation anti-SARS-CoV-2 Anti-spike anti-spike antibody Anti-viral anti-viral antibody antibodies antibody antibody affinity apparent affinity binding antibody Blood complexes Concentration convalescent COVID-19 antibody determine diagnostics Direct faster fluorescence microscopy funding source HDIA higher affinity Human plasma immunoassay immunoassays individuals Interpretation Microparticle parameter Patient plasma Protein provided quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination serum turn vaccinated individuals vaccination were used [DOI] 10.1016/j.ebiom.2021.103796 PMC 바로가기 [Article Type] Article
Severe breakthrough COVID-19 with a heavily mutated variant in a multiple myeloma patient 10 weeks after vaccinationCase report Published on 2022-01-012022-10-05 Journal: Clinical Infection in Practice [Category] 변종, [키워드] anti-spike antibody antibody Antibody Response B.1.1.529 B.1.628 breakthrough Breakthrough infection Correlate of protection COVID-19 detectable determine develop E484Q experiments healthy controls immune escape mutation Immunocompromised in viral increased risk mRNA-1273 Multiple Multiple myeloma mutated mutations N440K omicron Patient Prevent Protective response Result S194L SARS-CoV-2 second vaccination severe severe COVID-19 spike Spike protein the SARS-CoV-2 vaccination variant virus [DOI] 10.1016/j.clinpr.2021.100130 [Article Type] Case report
Longitudinal Analysis of Antibody Responses to the mRNA BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis: A 6-Month Follow-UpMedicine Published on 2021-12-242022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] age-matched control analyzed anti-spike antibody anti-Spike IgG BNT162b2 boost Chronic hemodialysis close monitoring Cohort cohort analysis collected Control correlated COVID-19 COVID-19 infection dose ELISA exclusion Factor first dose fraction Hemodialysis hepatitis B higher risk IgA level IgG IgG level IgM immunosuppressive therapy lack longitudinal Lower maintenance mRNA BNT162b2 of BNT162b2 outcomes participant Patient patients performed persistence quantified receive Responder response resulting SARS-CoV-2 second dose sera Seroconversion seroconvert Seronegativity specific antibody vaccination Vaccine vaccine dose Vaccines while [DOI] 10.3389/fmed.2021.796676 PMC 바로가기 [Article Type] Medicine
Waning Humoral Response 3 to 6 Months after Vaccination with the SARS-COV-2 BNT162b2 mRNA Vaccine in Dialysis PatientsArticle Published on 2021-12-232022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] albumin anti-spike antibody antibody Antibody Response BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine booster control group COVD-19 COVID-19 COVID-19 infection decrease dialysis dose End stage renal disease Humoral immunity individual infected with COVID-19 male Month Participants Patient patients remained reported response SAR SAR S-COV-2 second dose Serious Adverse Event seroconversion response vaccination Vaccine vaccine dose waning were infected [DOI] 10.3390/jcm11010064 PMC 바로가기 [Article Type] Article
SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infectionResearch Article Published on 2021-12-202022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome anti-spike antibody bind binding binding domain block caused composed coronavirus COVID-19 pandemic demonstrated enzymatic activity enzyme expression Extracellular fused fusion protein globe Health host cell host cells human IgG1 In-vitro Infection inhibit inhibit SARS-CoV-2 Interaction interfere Mutation neutralize Neutralizing not affected physically problem RBD RBD-Ig receptor Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2-infected patients specific treatment spike glycoprotein the RBD the SARS-CoV-2 Treatment viral entry virus virus entry virus infection virus titers [DOI] 10.1371/journal.ppat.1010175 PMC 바로가기 [Article Type] Research Article