Safety and antibody response to two-dose SARS-CoV-2 messenger RNA vaccination in patients with multiple myeloma다발성 골수종 환자에서 2 용량 SARS-COV-2 메신저 RNA 백신 접종에 대한 안전성 및 항체 반응Research Published on 2021-12-272022-09-01 Journal: BMC Cancer [Category] 진단, [키워드] Adverse reaction Adverse reactions antibody Antibody Response binding domain characterized COVID-19 detectable dose immunogenicity leads Messenger RNA mRNA vaccination mRNA vaccine mRNA vaccines Multiple myeloma Patient Rate RBD reactogenic reassurance receive Result Safety SARS-CoV-2 Seroconversion seroconverted supplementary material therapy trials vaccination Vaccine Vaccine hesitancy were excluded [DOI] 10.1186/s12885-021-09097-5 PMC 바로가기 [Article Type] Research
Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World SettingImmunology Published on 2021-12-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome binding domain CD4+ CD4+ T cell CD8+ T cell cellular cellular immune responses characterization characterized clinical trials Concentration concerning conditions coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines COVID‐19 cytokine demonstrated detectable dose dosing interval elicited Evidence Frequency humoral humoral immune response humoral immune responses IFN-γ IgG IgG response IL-2 immune response Immunity inactivated Inactivated vaccine individual individuals induced longitudinal analysis majority male membrane neutralizing antibody nucleocapsid parameter participant peptide pool Protein raised recognizing response S-RBD SARS-CoV-2 SARS‐CoV‐2 second dose second vaccination setting significantly higher single vaccine sustained the SARS-CoV-2 TNF-α vaccination Vaccine vaccinees waned while [DOI] 10.3389/fimmu.2021.802858 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infectionResearch Article Published on 2021-12-202022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome anti-spike antibody bind binding binding domain block caused composed coronavirus COVID-19 pandemic demonstrated enzymatic activity enzyme expression Extracellular fused fusion protein globe Health host cell host cells human IgG1 In-vitro Infection inhibit inhibit SARS-CoV-2 Interaction interfere Mutation neutralize Neutralizing not affected physically problem RBD RBD-Ig receptor Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2-infected patients specific treatment spike glycoprotein the RBD the SARS-CoV-2 Treatment viral entry virus virus entry virus infection virus titers [DOI] 10.1371/journal.ppat.1010175 PMC 바로가기 [Article Type] Research Article
Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA AssayProtocol Published on 2021-12-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy ACE2 added addition Angiotensin converting enzyme-2 binding binding domain binding inhibition assay co-occurrence competitive ELISA condition Containment measure containment measures Control correlated cross-reactivity detect detection Efficacy ELISA ELISA assay high throughput immune include initial interactions Live virus live viruses murine neutralization Neutralization assay Neutralizing non-specific parameter plaque reduction neutralization Precision Prevent protocol R 2 RBD RBD-ACE2 reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike secondary antibody sensitive sensitivity sera serum soluble ACE2 specificity Spike protein stages Treatment Vaccine development validation Virus neutralization VNT [DOI] 10.3390/vaccines9121493 PMC 바로가기 [Article Type] Protocol
Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America유럽과 미국에서 백신 내성 돌연변이를 드러내는 SARS-CoV-2 진화 메커니즘Article Published on 2021-12-162022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] America antibody binding domain can not complementary disrupt domain drugs Europe favor Frequency mechanism Mutation mutations N501Y natural selection neutralize occurred Occurrence omicron pathway Protein recent reduced SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes trajectory Transmission vaccination rate vaccination rates Vaccine Viral viral evolution viral infectivity virus [DOI] 10.1021/acs.jpclett.1c03380 PMC 바로가기 [Article Type] Article
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallographyArticle Published on 2021-12-162022-10-04 Journal: Nature Communications [Category] SARS, 변종, 치료제, [키워드] Analysis antibodies antibody Antibody fragment therapy Antibody fragments Antigen binding domain biochemical biologic classical coronavirus Critical delta variant effective epitope exceeded flexible full-length greater highlight identify immune system Immunoglobulin inaccessible lineages live SARS-CoV-2 mechanism motif neutralize New Phylogenetic Protein Protein design pseudotype RBD receptor Receptor binding domain recognize SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 neutralization SARS-CoV2 SARSCoV-2 screened shark the RBD the SARS-CoV-2 therapeutic agent unique utility variable viral neutralization virus Virus neutralization X-ray crystallography [DOI] 10.1038/s41467-021-27611-y PMC 바로가기 [Article Type] Article
Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structureResearch Article Published on 2021-12-062022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] accumulation ACE-2 receptor Algorithms analyzed applied approach Asia B.1 B.1.1 B.1.1.7 binding domain clade Concordance COVID-19 detect determine distribution distributions Effect Europe evaluated exhibit genome sequence genomic GISAID database help hydrophilicity Impact in silico increase in introduced lab less Mutation mutations pandemic Patient Protein SARS-CoV-2 genome SARS-CoV-2 genome sequence Spike protein submitted the SARS-CoV-2 genome the spike protein timeline Treatment strategies Turkey USA vaccination variant variations WHO World Health Organization [DOI] 10.1371/journal.pone.0260438 PMC 바로가기 [Article Type] Research Article
Antibody response induced by the BNT162b2 mRNA COVID-19 vaccine in a cohort of health-care workers, with or without prior SARS-CoV-2 infection: a prospective studySARS-CoV-2 감염 여부에 관계없이 의료 종사자 집단에서 BNT162b2 mRNA COVID-19 백신에 의해 유도된 항체 반응: 전향적 연구Article Published on 2021-12-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis Anti-spike antibody Antibody Response binding domain BNIT162b2 mRNA COVID-19 vaccine BNT162b2 BNT162b2 mRNA Cohort coronavirus correlation COVID-19 COVID-19 vaccine elapsed female first dose HCW health-care Health-care workers IgG IgM individual individuals Infection interquartile range IQR measure mRNA naïve individuals no infection positive Presence Prospective Study Protein respiratory SARS-CoV-2 SARS-COV-2 infection second dose significantly significantly higher single dose single vaccine Symptoms tested the antibody response titre Vaccine was used [DOI] 10.1016/j.cmi.2021.07.024 PMC 바로가기 [Article Type] Article
Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced ImmunityBNT162b2 SARS-CoV-2 백신 유도 면역의 알파 및 베타 변이체에 대한 중화의 연령 의존적 감소Research Article Published on 2021-12-012022-09-10 Journal: Microbiology Spectrum [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age All participants anti-RBD antibody antibody level antibody levels Antibody test Antigen basic Beta binding domain BNT162b2 BNT162b2 vaccine Clinical characteristics collected Coronavirus-2 correlated Cutoff decrease female groups Health care Health care worker health care workers heterogeneity high risk higher risk Humoral immunity Immunity include individual Infection interquartile range introduced IQR median mRNA vaccine mRNA vaccines neutralization Neutralizing Neutralizing activity Neutralizing antibodies of BNT162b2 Older age participant Patient patient age positive Pseudotyped virus questionnaire Questionnaires Randomly Receptor-binding domain reduction respiratory SARS-CoV-2 SARS-COV-2 infection second dose selected sera serum dilution Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Toyama U/mL university vaccination variant variants Viral viral variant Viral variants virus viruses was obtained were measured wild type wild-type wild-type SARS-CoV-2 wild-type virus [DOI] 10.1128/Spectrum.00561-21 PMC 바로가기 [Article Type] Research Article
Monoclonal antibodies for the treatment of COVID-19 patients: An umbrella to overcome the storm?코로나19 환자 치료를 위한 단클론항체: 폭풍우를 이기는 우산?Review Published on 2021-12-012022-09-11 Journal: International immunopharmacology [Category] SARS, 변종, 임상, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike antibody authorization binding domain clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated Effectiveness effort Emergency Emergency use authorization Epitopes Evidence focus impair indications individual mAb mAbs management Mild mild to moderate moderate monoclonal antibodies monoclonal antibody Mutation neutralization overcome pandemic Pneumonia pressure Prevent progression PROTECT Receptor binding domain respiratory S protein SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe disease the S protein the SARS-CoV-2 therapy Transmission Treatment treatment of COVID-19 Treatment strategies vaccination variants [DOI] 10.1016/j.intimp.2021.108200 PMC 바로가기 [Article Type] Review