Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive InteractionsArticle Published on 2021-09-292022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] binding Biological biothermodynamics Cell characterized Coinfection competing determine Gibbs energy growth Host host cell host cell receptor Infection Interaction interactions Interference microorganism Multiple organism outcome permittivity physical Predictive Prevent receptor Result shown strain susceptibility virus viruses [DOI] 10.3390/microorganisms9102060 PMC 바로가기 [Article Type] Article
The nasal symbiont Staphylococcus species restricts the transcription of SARS-CoV-2 entry factors in human nasal epitheliumArticle Published on 2021-09-252022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract ACE2 angiotensin-converting enzyme 2 Biological Biological sciences cellular cellular receptor Complete Coronavirus-2 Evidence expressed Factor Host host protease Human indicate Invasion lung tissue Microbiology Molecular biology nasal nasal epithelium nasal mucosa reduce reduced reduction Regulation restrict SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry factor SARS-CoV-2 transmission significantly Staphylococcus symbiont TMPRSS2 Transcription transmembrane serine protease transmitted Virology [DOI] 10.1016/j.isci.2021.103172 PMC 바로가기 [Article Type] Article
Risk Factors of In-Hospital Mortality in Non-Specialized Tertiary Center Repurposed for Medical Care to COVID-19 Patients in RussiaArticle Published on 2021-09-152022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 95% CI alcohol analyzed arterial Arterial hypertension Biological body mass index Care center Clinical outcome collected Comorbidities Complication Computed tomography coronavirus disease Coronavirus pneumonia COVID-19 COVID-19 patient CT scan demographic characteristics died disease echocardiographic Factor Gender Hospital stay Hospitalization hospitalized patient hypertension in-hospital mortality increase in Laboratory male Mortality Myocardial infarction Neutrophil-to-lymphocyte ratio Older age Patient prevalent Protective provided Radiographic Result risk factor Risk factors risk of death Russia severe disease significant increase smoking Stratification stroke Support Tertiary the patient transported [DOI] 10.3390/diagnostics11091687 PMC 바로가기 [Article Type] Article
Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19COVID-19 유무에 관계없이 입원 환자의 대사 이질성에 기여하는 생물학적 및 임상적 요인Observational Study Published on 2021-09-022022-09-12 Journal: Cells [Category] SARS, 임상, 진단, [키워드] accumulated Accuracy acutely ill patient acylcarnitine Admission Amino acid Analysis Antigen Biological body mass index changes in Characteristics clinical Clinical data clinical variable Cohort collected Corona COVID-19 COVID-19 patient Critical disease severity enzymatic activity Factor fatty Fatty acid feature follow-up study highest Hospitalization illnesses independent information Kynurenine lowest machine learning model marker metabolic metabolism metabolomics overlapping pandemic patients performed plasma positive Prognosis progression provide Significant subject tested Tryptophan yielding [DOI] 10.3390/cells10092293 PMC 바로가기 [Article Type] Observational Study
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients폰 빌레브란트 인자와 ADAMTS13 축의 불균형은 코로나19 중환자에서 혈전 과정의 원인이라기보다는 오히려 강한 염증과 내피 손상의 바이오마커Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커, [키워드] ADAMTS13 ADAMTS13 conformation Admission alveolar capillaries alveolar capillary Antigen Biological Biomarker Biomarkers Clinical features contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer deaths deficiency disintegrin driver Drivers elevated endothelial damage enrolled factor V fibrinogen hallmark hemolytic anemia hospital Imbalance Immune-mediated induce Inflammation Laboratory parameters male-to-female ratio median age microangiopathic hemolytic anemia microthrombi Microthrombosis Mortality open Patient patients Platelet Pulmonary embolism pulmonary embolisms purpura Quantitative reported Seven severe deficiency specificity thrombocytopenia thrombocytopenic purpura thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura type I von Willebrand factor vWF [DOI] 10.1111/jth.15445 PMC 바로가기 [Article Type] Article
Synthesis and Biological Evaluation of Honokiol Derivatives Bearing 3-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)oxazol-2(3H)-ones as Potential Viral Entry Inhibitors against SARS-CoV-2Communication Published on 2021-08-312022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019 coronavirus disease ACE2 ACE2 blocker activities analogue Antiviral antiviral activity antiviral efficacy antiviral molecules Bearing bind binding binding affinity Biological Biosafety Level 3 BLI caused contribute cortex COVID-19 demonstrated derivative develop effective ELISA assay examined Health Honokiol honokiol analogues host cell human Ace2 protein inhibitor inhibitory effect lower binding energy medication molecular docking parental Potential Research SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 viral SARS-CoV-2 virus infection strain synthesis the SARS-CoV-2 virus Viral entry inhibitors [DOI] 10.3390/ph14090885 PMC 바로가기 [Article Type] Communication
Influence of SARS-CoV-2 Virus Infection on the Course of Psoriasis during Treatment with Biological DrugsObservational Study Published on 2021-08-272022-10-04 Journal: Medicina [Category] MERS, SARS, 임상, [키워드] Administered Affect analyzed Area Biological biological drugs chain comparable control group Course COVID-19 COVID-19 disease COVID-19 pandemic diagnosed drug effective therapy eight Hospitalization index infected with SARS-CoV-2 influence material Mild observé Patient PCR positive psoriasis psoriatic arthritis reaction required Result RT-PCR SARS-CoV-2 SARS-COV-2 infection skin lesions statistically telephone contact therapy time Treatment [DOI] 10.3390/medicina57090881 PMC 바로가기 [Article Type] Observational Study
Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 LabsBioengineering and Biotechnology Published on 2021-08-132022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] activity Aerosols applied Biological biosafety biosecurity BSL BSL-2 BSL-3 BSL-3 laboratory BSL-4 Case history Community costly COVID-19 Culture diagnostic equipment Establishing group high containment biological laboratory include Laboratory Local Measures National organizations Performing required Research resource SARS-CoV-2 scenario Significance translational transmissible variants virus while work zoonosis [DOI] 10.3389/fbioe.2021.720315 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
National control laboratory independent lot testing of COVID-19 vaccines: the UK experiencePerspective Published on 2021-08-122022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] accelerate approach approval Biological clinical trial clinical trials Combination Control COVID-19 COVID-19 pandemic Critical effort independent Laboratory measure Medicine MHRA NIBSC pandemic provide public health Regulation Regulatory Research Stage Standard Vaccine vaccine availability Vaccine development viral infection [DOI] 10.1038/s41541-021-00368-7 PMC 바로가기 [Article Type] Perspective
Sensitive extraction-free SARS-CoV-2 RNA virus detection using a chelating resinArticle Published on 2021-08-092022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract Biological Biological sciences Biological sciences research methodologies buffer caused COVID-19 pandemic current Detection sensitivity diagnostic diagnostic test Direct initial lack Molecular Biology Experimental Approach Nasopharyngeal swab pathogen Patient PCR Quantitative Research reverse transcription PCR RNA RNA extraction RT-qPCR Safe SARS-CoV-2 SARS-CoV-2 RNA sensitive specimens supply shortage Swab Transport Treatment variety Viral transport medium Virology virus detection [DOI] 10.1016/j.isci.2021.102960 PMC 바로가기 [Article Type] Article