Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2SARS-CoV-2에 대한 보호 프로토타입-베타 및 델타-오미크론 키메라 RBD-이량체 백신Article Published on 2022-06-232022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] approach Beta breakthrough infections chimeric circulating COVID19 COVID19 vaccine Delta delta variant develop dimeric domain elicited forms immunogen structure immunogens Infection macaques mice multivalent vaccine neutralization omicron Omicron variant pandemic prevalent protein subunit vaccine prototype RBD RBD-dimer Receptor-binding domain SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera Subunit vaccine supported Vaccine vaccine protection variant variant of concern variants VoC ZF2001 [DOI] 10.1016/j.cell.2022.04.029 PMC 바로가기 [Article Type] Article
Individuals With Weaker Antibody Responses After Booster Immunization Are Prone to Omicron Breakthrough Infections추가 접종 후 항체 반응이 약한 개인은 오미크론 돌발 감염에 걸리기 쉽습니다.Article Published on 2022-06-232022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% confidence interval anti-SARS-CoV-2 IgG antibody Anti-spike anti-spike antibodies anti-spike antibody antibody Antibody titer binding antibody body mass index booster booster vaccination Breakthrough infection breakthrough infections conditions COVID-19 Essen healthcare worker help humoral humoral immune response identify immune independent individual Infection information Level neutralization neutralization capacity occur omicron participant potential risk prone provided response risk routine SARS-CoV-2 SARS-CoV-2 IgG antibody serum sample severe COVID-19 Sex smoking status subject threshold university vaccination vaccination against COVID-19 Vaccine Virus neutralization were measured [DOI] 10.3389/fimmu.2022.907343 PMC 바로가기 [Article Type] Article
An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo조작된 ACE2 미끼는 SARS-CoV-2 Omicron 변이체를 중화하고 생체 내 감염으로부터 보호합니다.Article Published on 2022-06-222022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 Alpha alpha and delta variants Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 BNT162b2 breakthrough infections Casirivimab chimeric Complete conserved conserved region contributed convalescent serum deep delta variant Delta variants demonstrated dose drugs effective enzyme escape escaped evade exhibited Frequency hamster hamsters human ACE2 Imdevimab immunized in vivo individual Infection multiple mutation multiple mutations Mutation N-terminal domain neutralization neutralization titer neutralize neutralized of BNT162b2 omicron parental prevented pseudo-virus raising Receptor binding domain sarbecovirus SARS-CoV-2 variant SARS-CoV-2 variants sensitivity serum serum sample serum samples Sotrovimab Spike protein Spike proteins target the SARS-CoV-2 the spike protein theory therapeutic therapeutic antibodies therapeutic effect transgenic mice vaccination Vaccines variant variants Viral viral mutation virus virus-neutralizing Wuhan strain [DOI] 10.1126/scitranslmed.abn7737 PMC 바로가기 [Article Type] Article
Safety evaluation of the single-dose Ad26.COV2.S vaccine among healthcare workers in the Sisonke study in South Africa: A phase 3b implementation trial남아프리카의 Sisonke 연구에서 의료 종사자를 대상으로 한 단회 용량 Ad26.COV2.S 백신의 안전성 평가: 3b상 시행 시험Clinical Trial Published on 2022-06-212022-09-12 Journal: PLoS Medicine [Category] MERS, 임상, 진단, [키워드] 48 hour Ad26.COV2.S vaccine adverse event AEs African age body ache breakthrough infections categories clinical clinical trials collected COVID-19 COVID-19 infection death demonstrated Effectiveness eligible evaluated expected Fever Final first vaccination Frequency HCW HCWs headache healthcare healthcare worker hospitalisations Immune system disorder implementation Implementation study IMPROVE incidence rate increasing age Infection injection site pain janssen men morbidity MOST National nervous system disorder occurred Open-label Pan participant Participants Phase 3 trials reactogenicity reactogenicity event Registered registry reported SAE SAEs safety evaluation safety profile serious AE single-arm design South South Africa Support Symptoms syndrome System thrombosis Trial triggered vaccination Vaccine [DOI] 10.1371/journal.pmed.1004024 PMC 바로가기 [Article Type] Clinical Trial
Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers예방 접종을 받은 의료 종사자 간의 B.1.617.2 Delta 변이의 전파Article Published on 2022-06-212022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] analysed approach B.1.617.2 benefit breakthrough infections Care Computational approaches delta variant described dose eight epidemiological HCW HCWs Health Health care Health care worker health care workers healthcare worker highlight hospital India individual Infection infection control less likelihood measure Patient populations potential for transmission Probability Re-infections recipient reduce reported SARS-CoV-2 sequence Transmission transmissions transmitted vaccination Vaccine viral spread virus genome virus transmission [DOI] 10.1038/s41598-022-14411-7 PMC 바로가기 [Article Type] Article
Athletes’ Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients운동선수의 중간엽 줄기세포는 오마이크론에 감염된 환자의 세포 치료를 위한 최선의 선택이 될 수 있습니다Article Published on 2022-06-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar anti-apoptotic Anti-inflammatory antioxidant athlete Breakthrough infection breakthrough infections caused Cell cell survival choice coronavirus COVID-19 Cytokines Defense defense mechanisms effective epithelial cells exercise growth growth rate growth signaling highlight immunomodulatory incidence Inflammation Ischemia mechanism microenvironment Mutation New omicron outcome oxidative stress patients Re-infections reduce reduced respiratory epithelial cell respiratory epithelial cells SARS-CoV-2 secretion sport STEM stem cell stem cells stem-cell therapy suggested Support survival therapy transplantation Treatment Vaccine variant variants [DOI] 10.3390/cells11121926 PMC 바로가기 [Article Type] Article
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR Research Published on 2022-06-132022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] Activation Antigen-specific T cells antigens breakthrough infections Cell cellular immunity chemokine correlated CXCL10 expression functional helping IFN-γ Immunity magnitude Messenger RNA monocyte mRNA normalized PCR populations protective immune response quantification quantitative PCR Rapid revaccination risk RNA extraction SARS-CoV-2 SARS-CoV-2 viral secrete stimulate T cell T cell activation [DOI] 10.1038/s41587-022-01347-6 [Article Type] Research
High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium의료 종사자의 BNT162b2 백신 접종으로 유도된 잔류 체액 및 세포 면역에도 불구하고 우려되는 돌발 감염의 SARS-CoV-2 변종 높은 발생: 벨기에의 장기 추적 연구Clinical Trial Published on 2022-06-092022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Alpha analyzed antibody B cell B cells Belgium binding BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections caused CD4 CD8 Cellular immune response cellular immunity circulating concern coronavirus COVID-19 delta variant delta VoCs domain Follow-up functional healthcare healthcare worker Healthcare workers humoral immune responses immunoassays in vitro incidence individual induced initiated interferon interferon-γ investigated Long-term follow-up Long-term monitoring mitigate MONITOR neutralization not correlated performed pseudovirus reduced reported residual respiratory SARS-CoV-2 SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells serology severe acute respiratory syndrome Coronavirus single-center subject symptomatic T cells Trial vaccination Vaccine-induced immunity variant variants variants of concern was determined were assessed [DOI] 10.3390/v14061257 PMC 바로가기 [Article Type] Clinical Trial
ChAdOx1-S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccinationChAdOx1-S 아데노바이러스 벡터백신을 비강내 투여하여 근육주사에 비해 점막면역력이 우수함Article Published on 2022-06-012022-09-12 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adenoviral vector adenoviral vector vaccine Administered Antibody titer applied approved BALB/c mice breakthrough infections CD8 T cell Cellular immune response ChAdOx1-S Complete COVID-19 COVID-19 pandemic elicit elicited exhibiting expressing form full-length humoral IgA IgG antibody Immunity immunization immunized immunized mice induce intramuscular intramuscular vaccination intramuscularly intranasal intranasally lung mice mucosa mucosal mucosal immunity neutralized neutralizing capacity percentage phenotype Prevent Protein robust SARS-CoV-2 sera spike the disease the Spike tissue vaccination Vaccine vaccine vectors. vectors virus entry [DOI] 10.1002/eji.202249823 PMC 바로가기 [Article Type] Article
Long-term immunity in convalescent Syrian hamsters provides protection against new-variant SARS-CoV-2 infection of the lower but not upper respiratory tract회복기 시리안 햄스터의 장기 면역은 상부 호흡기가 아닌 하부 호흡기의 새로운 변종 SARS-CoV-2 감염에 대한 보호를 제공합니다Article Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome alpha and delta variants Breakthrough infection breakthrough infections circulating antibodies circulating antibody convalescent coronavirus coronavirus 2 COVID-19 delta variant effective hamster Hospitalization immune patients Immunity Infection Infectious virus infectious viruses less long-term immunity Lower respiratory tract Preexisting immunity provide Reinfection Replication SARS-CoV-2 SARS-COV-2 infection sera Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severe acute respiratory syndrome-related coronavirus 2 severe disease shedding upper respiratory tract Vaccine variants variants of concern [DOI] 10.1002/jmv.27641 PMC 바로가기 [Article Type] Article