The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in PigletsArticle Published on 2019-03-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] accelerate affected approach Bacterial Cas9 cDNA Cell chromosome Clinical sign clone coronavirus CRISPR/Cas9 demonstrated determinant enteric enteric tropism experiment full-length gastroenteritis genetics growth help Mortality mutant N-terminal domain PK-15 platform Protein rescued Research Respiratory Coronavirus reverse genetics spike spike gene Spike protein survival TGEV transmissible gastroenteritis virus tropism Vaccine virulence virus [DOI] 10.3390/v11040313 PMC 바로가기 [Article Type] Article
Comprehensive structural variation genome map of individuals carrying complex chromosomal rearrangements복잡한 염색체 재배열을 가진 개인의 포괄적인 구조적 변이 게놈 지도Research Article Published on 2019-02-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] analyzed Author breakpoint Case series case sery CCR chromosomal rearrangement chromosome chromosome 1 chromosome 10 chromosome 2 chromosomes clinical setting clinical symptom Clinical symptoms complementary complex Comprehensive de novo Deletion demonstrated diagnostic disease disrupting experiment FIVE Genes Genetic Genome genomic high resolution individual karyotyping Laboratory molecular nucleotide optical phenotype power problem problems Region resolved sensitivity sequence Sequencing Structural variation Structure structures the patient unique was obtained WGS whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007858 PMC 바로가기 [Article Type] Research Article
CDI/CDS system-encoding genes of Burkholderia thailandensis are located in a mobile genetic element that defines a new class of transposonBurkholderia thailandensis의 CDI/CDS 시스템 인코딩 유전자는 새로운 종류의 트랜스포존을 정의하는 이동성 유전 요소에 있습니다.Research Article Published on 2019-01-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition allele Bacteria Bacterial Burkholderia CDS Cell cells Characteristics chromosome Community community development composed cooperation Critical DNA dsDNA element Escherichia coli Evidence facilitate fitness functional Genes genes encoding Genetic genetic material growth helping immune Immunity induce inhibit insertion insertion sequence Interaction Intercellular communication involved killing lack left mechanism microbial Microbial communities Mobility occur Organisms phenomenon Phenotypes Propagation Protein provide reaction required self sequence sequences Signaling Support synthesis target cell transposon turn [DOI] 10.1371/journal.pgen.1007883 PMC 바로가기 [Article Type] Research Article
Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities포도당-6-인산 탈수소효소 결핍에서 성별-지식 격차 해소: 도전과 기회Review Published on 2019-01-032024-08-26 Journal: International Health [Category] 말라리아, [키워드] chromosome Gender glucose-6-phosphate dehydrogenase point-of-care X-inactivation [DOI] 10.1093/inthealth/ihy060 PMC 바로가기 [Article Type] Review
Genome-wide CRISPR-dCas9 screens in E . coli identify essential genes and phage host factorsE의 게놈 전체 CRISPR-dCas9 스크린. 대장균은 필수 유전자와 파지 숙주 인자를 식별합니다.Research Article Published on 2018-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition applied Bacteria Bacterial bacterial capsule bacterial gene bacterial genes bacteriophage bacteriophages capsids Cas9 Cas9 RNA-guided nuclease catalytic Cell chromosome colanic acid convenience CRISPR CRISPR-Ca CRISPR-dCas9 screen CRISPRi dCas9 dCas9 protein detect E . coli expression level Factor functional Gene Expression Genes Genetic genetic interactions genetic screens Genome genomes growth guide RNA High-throughput genetic screen High-throughput genetic screens highlight highlighting Host identify infection process Interaction involved kill library mechanism medium modulate mutant over pathway phage phage λ phages phages λ phenotype Phenotypes Plasmid powerful tool predict progeny random remained reported required resistance mechanism Screen sgRNA sgRNAs technique tested transduction assay utility [DOI] 10.1371/journal.pgen.1007749 PMC 바로가기 [Article Type] Research Article
Synaptogyrin-2 influences replication of Porcine circovirus 2Synaptogyrin-2는 돼지 써코바이러스 2의 복제에 영향을 미칩니다Research Article Published on 2018-10-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Amino acid Antigen association Author Cas9 Cell chromosome chromosome 7 clone complex conducted conserved CRISPR CRISPR-Cas9 disease disease susceptibility Diseases Dissection DNA virus domain Evidence evidence of ExoN explained expression General health Genetic genetic component genetic test genetic tests genetics Genome-wide association study genomic Genotype group of disease group of diseases growth Health Host host genetics hpi identification illnesses immune response immune system in viral incidence Infection influence involved leukocyte locus mammals Missense mutation Mutation Pathogenesis phenotypic phenotypic variance phenotypic variation PIGS polymorphism Population predict Protein provided proximal end QTL replicate Replication Research responsible RNA-sequencing severity sick single-stranded DNA SNP suggested supernatant susceptibility susceptible SYNGR2 the strongest underlie variant Variation Viral Viral load viral replication viral titer Viremia virus Welfare wildtype [DOI] 10.1371/journal.pgen.1007750 PMC 바로가기 [Article Type] Research Article
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania심각한 말라리아 및 탄자니아 북동부의 선택적 압력과 관련된 새로운 유전적 다형성Research Article Published on 2018-01-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article
HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expressionHPV 통합은 높은 바이러스 종양 유전자 발현을 유도하는 바이러스 세포 슈퍼 인핸서를 생성하기 위해 세포 인핸서를 가로채고 다량체화합니다.Research Article Published on 2018-01-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation amplification amplified BRD4 Cancer cancers cellular cellular DNA chromatin chromosome composed de novo dysregulated element enhancer Epigenetic example expressed expression generate genesis Genetic Genome genomic H3K27ac Host HPV human cancers human papillomavirus Infection integration intergenic region loci locus marker mechanism molecular mutations Next-generation sequencing oncogene oncogenesis papillomavirus positive promote promoted provide random regulatory region responsible sequence super-enhancer transcript Transcription tumors Type unique upstream Viral viral DNA viral genome virus [DOI] 10.1371/journal.pgen.1007179 PMC 바로가기 [Article Type] Research Article
Genome wide comparison of Ethiopian Leishmania donovani strains reveals differences potentially related to parasite survival에티오피아 Leishmania donovani 균주의 게놈 전체 비교는 기생충 생존과 잠재적으로 관련된 차이점을 보여줍니다Research Article Published on 2018-01-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis Author biological processe carried caused Chain Reaction chromosome chromosome 10 clone clones CNV Concentration copy number correlated correlation deaths described difference drug drug resistance drug treatment drugs East Ecology Ethiopian examined example exhibiting foci folate genetic difference genetic differences genomic sequencing Genotype Good group groups HIV homolog Indian subcontinent involved isolate isolates karyotype Leishmania Leishmania donovani Leishmaniasis methotrexate molecular functions MTX not correlated nucleotide occur parasite parasites Patient phenotype polymerase chain polymerase chain reaction polymorphism Quantitative quantitative polymerase chain reaction Region regions reported resulting reveal sensitivity single copy single nucleotide Single nucleotide polymorphism SNP strain survival Treatment unique Variation vectors viability visceral leishmaniasis WGS whole genome whole genome sequence [DOI] 10.1371/journal.pgen.1007133 PMC 바로가기 [Article Type] Research Article
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article