Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trial
COVID-19(ZILU-COV)로 인한 급성 저산소 호흡 부전 환자의 질루코플란: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약
Letter
[키워드] 24 hour
24 hours
acute hypoxic respiratory failure
acute lung injury
acute respiratory distress syndrome
addition
Adult patient
alveolar pressure
antibiotic
Antibiotics
anticipated
arterial pressure
Bacterial
blinded
Blinding
Caregivers
ceftriaxone
characterized
ciprofloxacin
clinical
Clinical course
Combination
comparator
comparator Patients
complement
complement C5 inhibition
complement pathways
complement system
component
components
control arm
control group
COVID-19
COVID-19 patient
CT scan
Cytokine release syndrome
defined
discharge
discharged patient
discharged patients
disease
dissemination
Effect
Efficacy and safety
element
eligibility criteria
EudraCT
exclusion criteria
experimental arm
Fungal infection
history
hospital discharge
hospitalized patient
hospitalized patients
hospitals
hypoxia
hypoxic respiratory failure
ICU
ICUs
Identifier
improving oxygenation
inclusion criteria
individual
Infection
inhibiting
inhibitor
Interactive Web Response System
invasive
IV infusion
LDH
lead
lung
Lung injury
lymphopenia
Mechanical
mechanical ventilation
median
meningococcal disease
meningococcal infections
number
objective
Open-label
open-label trial
outcome
oxygen
oxygen)
Oxygenation
pandemic
PaO
parameters
Partial
participant
Participants
Patient
Phase 2
predict
predisposition
primary endpoint
promote
prophylactic antibiotics
protocol
randomisation
randomised
randomised controlled trial
randomization
Randomized
receive
recent
recruited
recruitment
REDCap
Registered
repair mechanism
Respiratory failure
response
Sample size
SARS-COV-2 infection
Serum ferritin
SIGN
SpO2
Standard of care
status
Study protocol
subcutaneously
supplemental oxygen
supplementary material
System
systemic cytokine release syndrome
Trial
Trial registration
Ventilation
Version
Web
website
zilucoplan
[DOI] 10.1186/s13063-020-04884-0 PMC 바로가기 [Article Type] Letter
[DOI] 10.1186/s13063-020-04884-0 PMC 바로가기 [Article Type] Letter