conformational change

[키워드] absence activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered alpaca antibodies antibody Attention battle binding binding mode binding modes Bivalent catalyzed caused Cell cellular membrane cellular membranes change Combination combinations complex conformation conformational change Consequences coronavirus COVID-19 cryo-EM Crystallography determined by domain effective epitope Epitopes escape mutant escape mutants Evolution experiment experiments expression fusion Health care health care systems High-risk patients immune system immunization immunized inactivated inactivated virion inactive independent induce Infection information inhalation inhibit inhibited Interaction interactions lead llama mechanism Microscopy monoclonal antibodies multivalent mutants nanobodies nanobody neutralization neutralize neutralized Neutralizing Neutralizing activity observation offer pandemic passive immunization Perspective postfusion Premature Prevent prevented Protein RBD RBDs receptor receptor ACE2 Receptor binding Receptor binding domain respiratory resulting reveal Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike trimer Science severe acute respiratory syndrome Coronavirus Simultaneous Society Spike protein spike trimers Spread stomatitis strength Structure structures suppress suppressed target membrane target membranes the RBD the SARS-CoV-2 the spike protein to define Trigger triggered triggering triggers trimeric spike trivalent Vaccines variable vesicular stomatitis vesicular stomatitis virus Viral viral escape viral infection viral infections viral spike protein virion virions virus X-ray crystallography
[DOI] 10.1126/science.abe6230 PMC 바로가기 [Article Type] Research Article