ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesteraseResearch Article Published on 2024-05-142024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] binding protein conformational change Crystallography DNA repair Genomics inhibition mechanism phosphodiesterase: cancer RNA Small Angle X-ray Scattering (SAXS) structural biology [DOI] 10.1016/j.jbc.2024.107368 PMC 바로가기 [Article Type] Research Article
Investigation of SARS-CoV-2 nucleocapsid protein interaction with a specific antibody by combined spectroscopic ellipsometry and quartz crystal microbalance with dissipationArticle Published on 2022-11-152022-11-15 Journal: Journal of Colloid and Interface Science [Category] COVID19(2023년), SARS, 진단, [키워드] affected antibody Antibody and antigen interaction Antibody bivalent binding Antibody flexibility Antigen binding complex conformational change distribution Fab fragment immune complex Immune complexes immunosensor information Interaction investigation polyclonal produced Protein Quantitative quartz Quartz crystal microbalance with dissipation (QCM-D) Registered SARS-CoV-2 SARS-CoV-2 nucleocapsid Spectroscopic ellipsometry. was determined was used [DOI] 10.1016/j.jcis.2022.06.119 PMC 바로가기
Potential mechanisms of vaccine-induced thrombosisArticle Published on 2022-11-012022-11-15 Journal: European journal of internal medicine [Category] 유전자 메커니즘, 진단, [키워드] activate Ad26.COV2.S Adenovirus administration AdV vector antibodies antibody Autoimmune heparin-induced thrombocytopenia B cell Bacteria BNT162b cerebral venous sinuse ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical conformational change Contact COVID-19 COVID-19 vaccine COVID-19 vaccines described develop Effectiveness elicited events expression Factors Gene therapy heparin-induced thrombocytopenia hexone immune complex immune response Immune thrombocytopenia immunothrombosis IMPROVE induce intrinsic knowledge laboratory feature mechanism monocyte occur PF4 Platelet Platelets Potential proinflammatory Protein receiving resulting Spike protein splice subject syndrome T-cell thrombosis Vaccine Vaccine- induced immune thrombocytopenia and thrombosis. vectors Venous thrombosis viruses [DOI] 10.1016/j.ejim.2022.08.002 PMC 바로가기
Oligomerization-Dependent Beta-Structure Formation in SARS-CoV-2 Envelope ProteinArticle Published on 2022-10-312023-07-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] analytical ultracentrifugation conformational change envelope protein Fourier-transform infrared spectroscopy ion channel SARS-CoV-2 scission mechanism. [DOI] 10.3390/ijms232113285 PMC 바로가기
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral EntryArticle Published on 2022-10-142022-11-16 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 binding binding pocket block blocked broad inhibitor candidate cell-cell fusion cellular circulating SARS-CoV-2 variant Compound conformational change conserved coronavirus Critical Entry inhibitor entry inhibitors entry pathway facilitate function glycoprotein host cell Infection inhibitory effect interfere mode of action plasma membrane receptor Receptor binding domain required Ring SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike selective significantly Small molecules spike subsequent tested the SARS-CoV-2 these compound Tricyclic Trigger viral entry viral spike [DOI] 10.1021/acsinfecdis.1c00658 PMC 바로가기
Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기
Discovery of the Cryptic Sites of SARS-CoV-2 Papain-like Protease and Analysis of Its DruggabilityArticle Published on 2022-09-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료제, [키워드] activated active sites binding pocket binding site caused changes in conformational change CoV COVID-19 COVID-19 pandemic cryptic pocket cysteine protease develop drug druggability drugs help induce inhibitor inhibitors MixMD New coronavirus outbreak pandemic Pathogenesis patients physicochemical property PLPro predict probe Probeview promote Protein Research residue Respiratory disease resulting SARS-CoV-2 SARS-CoV-2 PLpro Schrodinger Site solvent target protein TRAPP treat virus was used [DOI] 10.3390/ijms231911265 PMC 바로가기
Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations ApproachArticle Published on 2022-09-092022-11-15 Journal: Drug design, development and therapy [Category] SARS, 신약개발, 치료제, [키워드] 3CL antiviral activity Antiviral treatment approved approved drug binding binding site carried caused Compound compounds conformational change coronavirus COVID-19 drug drug combination drug combinations Drug repurposing drug synergy Dynamics effective Efficacy enzyme Favipiravir identification in silico in vitro in vitro assays Infectious disease inhibitor inhibitory effect Ligand ligand docking M pro molecular Molecular dynamics simulation molecular dynamics simulations multiple binding sites. pandemic predicted protease Protein target Proteins provide reduced SARS-CoV-2 SARS-CoV-2 viral screened Simulation suggested synergism synergistic Toxicity Treatment treatments for COVID-19 virus [DOI] 10.2147/DDDT.S366423 PMC 바로가기
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escapeOmicron SARS-CoV-2 돌연변이는 스파이크 업-RBD 형태를 안정화하고 비-RBM-결합 단일클론 항체 탈출을 유도합니다Article Published on 2022-08-242022-09-11 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Accessibility ACE2 binding Analysis antibody complexes conformational change cryo-EM ENhance epitope expand human ACE2 immune evasion mechanism monoclonal antibody Mutation neutralizing antibody omicron performed Prevent prototype Receptor binding restrict S309 SARS-CoV-2 SARS-CoV-2 mutation stability Substitution substitutions target triggered up-RBD variants of concern VOCs [DOI] 10.1038/s41467-022-32665-7 PMC 바로가기 [Article Type] Article
Repurposing of anti-lung cancer drugs as multi-target inhibitors of SARS-CoV-2 proteins: An insight from molecular docking and MD-simulation studySARS-CoV-2 단백질의 다중 표적 억제제로서 항폐암 약물의 용도 변경: 분자 도킹 및 MD 시뮬레이션 연구로부터의 통찰력Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis binding affinity binding energy Cancer Capmatinib conformational change COVID-19 drug Dynamics evaluate Glycoproteins highest binding affinity inhibitors of SARS-CoV-2 molecular docking molecular docking studies Molecular docking study molecular dynamics Molecular dynamics simulation MPro pharmacokinetic PLPro Protein repurposing Research RMSD RMSF SARS-CoV-2 selected spike spike glycoprotein spike glycoproteins Spike protein therapeutic therapeutic agent [DOI] 10.1016/j.micpath.2022.105615 PMC 바로가기 [Article Type] Article