Drug targets for resistant malaria: Historic to future perspectivesarticle Published on 2018-08-312024-09-01 Journal: Biomedicine & Pharmacotherapy [Category] 말라리아, [키워드] Apicoplast cytoplasm drug targets malaria Mitochondria Plasmodium falciparum [Article Type] article
The Accessory Protein ORF3 Contributes to Porcine Epidemic Diarrhea Virus Replication by Direct Binding to the Spike ProteinArticle Published on 2018-07-282022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein ORF3 binding affinity Cell Cell culture cells confocal microscopy cytoplasm demonstrated diarrhea Direct Endoplasmic reticulum epidemic diarrhea expression expression plasmid FLAG flow cytometry full-length Golgi Golgi apparatus infected cells Interaction N-terminal Neonatal ORF3 ORF3 protein pathogen PEDV performed Porcine epidemic diarrhea virus Protein regulate Replication responsible S protein Spike protein Structure subcellular localization the S protein the Spike Viral proteins virus virus replication watery [DOI] 10.3390/v10080399 PMC 바로가기 [Article Type] Article
Cellular hnRNP A1 Interacts with Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus and Impairs Viral ReplicationArticle Published on 2018-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] cells cellular cytoplasm demonstrated epidemic diarrhea expression heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) in viral in vivo infected cells Infection inhibited multifunctional protein N protein nuclear nucleocapsid nucleocapsid protein nucleus PEDV porcine epidemic diarrhea virus (PEDV) positive pre-mRNA predicted Protein proteomic study Regulation Replication ribonucleoprotein thought translation virus [DOI] 10.3390/v10030127 PMC 바로가기 [Article Type] Article
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infectionResearch Article Published on 2018-01-252022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accessory gene accessory protein acute respiratory distress antiviral response antiviral signaling ARDS binding contribute coronavirus CoV cytoplasm cytoplasmic Evidence expressed expression Fatality rate highly pathogenic host protein human CoV human infections indicate infected cells Infection information inhibited inhibiting innate immune response Interaction interfere involved Isolation KPNA4 mechanism MERS-CoV Middle East mutant NF-κB NLS nuclear nuclear localization signal nucleus pathology Pathways Prevent pro-inflammatory cytokines Protein protein complex Proteins required respiratory syndrome coronavirus retained robust severe pneumonia shown subunit syndrome translocated translocation Transport wild-type virus [DOI] 10.1371/journal.ppat.1006838 PMC 바로가기 [Article Type] Research Article
Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
The immune response to secondary necrotic cells이차 괴사 세포에 대한 면역 반응Review Published on 2017-08-312022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] Apoptosis apoptotic cell apoptotic cells Autoimmunity Cancer Cancer immunotherapy Cell cell surface cytoplasm DAMPs disease Effect Efferocytosis human physiology immune response immunostimulatory implication Inflammation leakage membrane integrity Modification molecular pattern molecular patterns molecules necroptosis Necrosis necrotic necrotic cell necrotic cells neurodegenerative disorder neurodegenerative disorders Primary necrosis recent regulated released Research Secondary necrosis Secondary necrotic cells the cell [DOI] 10.1007/s10495-017-1413-z PMC 바로가기 [Article Type] Review
The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cellsResearch Article Published on 2017-03-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] A20 A549 activated acute respiratory distress adjust approach ARDS attenuate Cell cells cellular change characterized chromatin combinations Complete Concentration contribute coronavirus coronavirus-infected cells correlated cytoplasm cytoplasmic de novo gene Degradation enhancer enhancer region Epigenetic event example expected expression expression level expression of gene Factor fine-tune Gene Expression Genes genes encoding Genome genome-wide investigation genomic region HCoV-229E HKU1 Host host cell host cell cytoplasm host response human coronavirus 229E humans identify IKK IKKβ IL-1 immunomodulatory factor immunomodulatory function infected cell infections Inflammatory Inflammatory cytokine involved IκBα Lung disease mechanism mechanisms MERS-CoV metabolic processes Modification molecular molecular basis motif NEMO NF-κB NF-κB signaling NL63 nuclear nuclear chromatin nucleus OC43 p65 pathogenic Pathogens pathology promote promoter Protein provide recruited recruitment regulatory region Replication required restrict RNA Polymerase II RNA virus SARS-CoV second shown Signaling subunit syndrome These cells TNFAIP3 transcribed Transcription transcription factor Transcriptome Treatment Trigger upper respiratory tract upregulated gene upregulation variety viral replication virus virus replication Virus-host interactions Zoonotic coronavirus [DOI] 10.1371/journal.ppat.1006286 PMC 바로가기 [Article Type] Research Article
Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV GrowthArticle Published on 2017-01-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] activities addition binding caspase-3 Cell components cytoplasm Degradation ENhance Enhancing epidemic diarrhea growth host cell independent indicated infected cells interact Interaction knockdown mechanism N protein NPM1 nuclear translocation nucleocapsid Nucleolus nucleophosmin nucleus overexpression PEDV Prevent promoted PROTECT Protein proteolytic proteolytic cleavage Regulation replicate Replication required suppressed survival the N protein virus [DOI] 10.1038/srep39700 PMC 바로가기 [Article Type] Article
The nucleolar protein GLTSCR2 is required for efficient viral replicationArticle Published on 2016-11-082022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated attenuate blocking cells cellular contributed coronavirus cytoplasm cytoplasmic glioma host cell IFN-β Infection innate immune response NES nuclear nucleus protease Protein required RIG-I sequence suggested Support supported therapeutic translocation triple interaction tumor suppressor type I interferon USP15 viral infection viral replication [DOI] 10.1038/srep36226 PMC 바로가기 [Article Type] Article
Autophagy Negatively Regulates Transmissible Gastroenteritis Virus ReplicationArticle Published on 2016-03-312022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] activate activated addition antiviral response autophagic autophagy cells Complete cytoplasm Defense expression of gene gastroenteritis host cells increase in Infection inhibit inhibited innate immune LY294002 marker occurred pathway Protein Rapamycin reduce Regulatory Replication required shown siRNA TGEV triggered Vesicle virus virus replication viruses [DOI] 10.1038/srep23864 PMC 바로가기 [Article Type] Article