endothelial – Page 8 – Communicable Diseases Research

Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients

Observational Study

Published on 2022-03-012022-10-05
Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 임상,

[키워드] adult COVID-19 patient angiotensin Angiotensin II angiotensin-converting enzyme 2 appear Bioavailability cardiovascular risk factor contrary control subject correlated correlation COVID-19 COVID-19 patient COVID-19 patients disease severity endothelial Endothelial cell Endothelial dysfunction endothelial injury exacerbated highlight hospital hospitalized COVID-19 patients ICU ICU patient induce leucocyte marker Microvascular thrombosis nitric oxide non-ICU observational study occur oxidative stress Oxygenation PaO parameter pathogenic Patient peroxide plasma Plasma level R 2 receptor redox status reduced Research Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection septic patients Septic shock Serum level target thrombosis Vascular widespread
[DOI] 10.1016/j.ebiom.2022.103893 PMC 바로가기 [Article Type] Observational Study

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

SARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1
[DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article

Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity

Sirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다

Review

Published on 2022-03-012022-09-11
Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn
[DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review

The Potential of Dietary Bioactive Compounds against SARS-CoV-2 and COVID-19-Induced Endothelial Dysfunction

Review

Published on 2022-03-012022-10-30
Journal: Molecules [Category] COVID-19, MERS, SARS,

Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications

COVID-19에 대한 내피 기여: 메커니즘 및 치료적 의미에 대한 업데이트

Review

Published on 2022-03-012022-09-11
Journal: Journal of molecular and cellular cardiology [Category] SARS, 바이오마커, 비임상, 임상,

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19

COVID-19의 영향을 받는 환자의 임신 고혈압 장애에서 sFlt-1/PlGF 비율

Multicenter Study

Published on 2022-03-012022-09-11
Journal: Pregnancy hypertension [Category] 바이오마커,

[키워드] adjusted affected Analysis case analysis Comorbidities Comorbidity Complete Concentration control group controls COVID COVID-19 COVID-19 patient COVID-19 patients damage demographic differential diagnosis disorder endothelial Evolution Factor finding Follow-up greater hypertensive hypertensive disorders of pregnancy Infection kinase normotensive obesity outcome Patient patients preeclampsia Pregnancy Pregnancy comorbidities pregnant patient pregnant patients Prevalence recruited recruitment SARS-COV-2 infection SARS-CoV2 infection severity sFlt-1/PlGF ratio. syndrome the disease tyrosine Univariate analysis women
[DOI] 10.1016/j.preghy.2021.12.001 PMC 바로가기 [Article Type] Multicenter Study

Elevated plasma levels of epithelial and endothelial cell markers in COVID-19 survivors with reduced lung diffusing capacity six months after hospital discharge

병원 배출 6 개월 후 폐 확산 능력 감소 된 Covid-19 생존자에서 상피 및 내피 세포 마커의 혈장 수준 증가

Observational Study

Published on 2022-02-212022-09-01
Journal: Respiratory Research [Category] MERS, 바이오마커, 임상, 진단,

[키워드] abnormality acute disease acute respiratory distress acute respiratory distress syndrome Adhesion Molecule angiopoietin ARDS carbon monoxide Cell Characteristics circulating clinical Clinical characteristics COVID-19 diffusing diffusing capacity discharge disease DLCO Dyspnoea E-selectin elevated endothelial Endothelial cell endothelial marker Endothelial markers epithelial Epithelial markers Follow-up hospital discharge Hospitalization hypertension independent risk factor independent risk factors individuals intercellular intercellular adhesion molecule leukocyte Level lung lung damage Lung function marker multivariate regression analysis observational study Occurrence Older Organizing pneumonia pathophysiology Patient patients plasma Plasma levels Pneumonia Post-COVID Prospective Protease inhibitor Protein Pulmonary embolism pulmonary embolisms reduced respiratory distress Result risk factor Risk factors selectin Sequelae severe COVID-19 severity Severity Score SLPI Smokers spirometry suffered supplementary material survivor Survivors syndrome
[DOI] 10.1186/s12931-022-01955-5 PMC 바로가기 [Article Type] Observational Study

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19

INVENT COVID 시험: COVID-19에 의해 유발된 급성 호흡곤란 증후군이 있는 피험자를 대상으로 정맥 이마티닙 메실레이트(Impentri®)의 효능과 안전성을 조사하는 무작위 대조 시험을 위한 구조화된 프로토콜

Study Protocol

Published on 2022-02-162022-09-10
Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상,

[키워드] 1:1 28-day mortality acute respiratory distress acute respiratory distress syndrome Admission ARDS Berlin criteria bis in die Chain Reaction changes in characterized clinical trial coronavirus disease Coronavirus disease 2019 COVID COVID-19 death decrease demonstrated discharge disease severity double-blind edema Efficacy and safety endothelial Endothelial dysfunction Estimated Extravascular lung water hypoxemic Hypoxemic respiratory failure ICU Imatinib imatinib mesylate immune response include increase in index Inflammation inflammatory conditions inhibitor intensive care intensive care unit intravenous Invasive mechanical ventilation IV infusion Kinase inhibitor life-threatening lung Lungs mechanical ventilation mechanically ventilated mesylate moderate-severe Mortality multicenter Older outcome Oxygenation pandemic parallel-group parameter parameters participant pharmacokinetics Placebo placebo-controlled polymerase chain polymerase chain reaction positive Prevent protocol Pulmonary edema randomization Randomized Randomized controlled trial recruitment reduce reduction in reflected respiratory distress Respiratory failure SARS-CoV2 secondary study period subject syndrome therapy Tolerability Trial registration tyrosine tyrosine kinase inhibitor Vascular vascular permeability Ventilation ventilator-free day Ventilator-free days water widespread
[DOI] 10.1186/s13063-022-06055-9 PMC 바로가기 [Article Type] Study Protocol

Elevated Cytokine Levels in Plasma of Patients with SARS-CoV-2 Do Not Contribute to Pulmonary Microvascular Endothelial Permeability

SARS-CoV-2 환자의 혈장에서 증가된 사이토카인 수준은 폐 미세혈관 내피 투과성에 기여하지 않습니다

Research Article

Published on 2022-02-162022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] accounted ACE-2 receptor ACE2 antibody acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection angiopoietin antagonists antiinflammatory cytokines appear approach ARDS barrier dysfunction C3a C5a cause Cell changes in circulating Combination complement complements factors consecutive patient Control controls coronavirus cytokine Cytokines death demonstrated determine disrupt Effect eight Elevation endothelial Endothelial cell endothelial injury endothelial permeability enrolled evaluated Evidence evidence of Frequency greater growth factor heat inactivation human lung in vitro infections inhibitors labile Level lung magnitude mechanism Microvascular damage morbidity morbidity and mortality multiorgan failure Neutralizing antibodies neutralizing antibody occur patients patients hospitalized patients with SARS-CoV-2 permeability plasma positive control predicted produced proinflammatory cytokines provide pulmonary receptor receptor antagonists respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 plasma selected severe acute respiratory syndrome Coronavirus severe complication severe complications Spike protein subsequent susceptible syndrome the SARS-CoV-2 thrombin TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability Vascular vascular endothelial growth factor Vascular injury vascular permeability VEGF
[DOI] 10.1128/spectrum.01671-21 PMC 바로가기 [Article Type] Research Article

COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences

Cell and Developmental Biology

Published on 2022-02-152022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] ACE2 addition arrythmia aspect Cardiomyopathy cardiovascular disease cardiovascular event change Clinical finding clinical observation co-morbidity consequence Corona coronavirus 2 COVID-19 COVID-19 pathology COVID-19 patient Critical current CVD develop diabete disease endothelial Endothelial cell Endothelial dysfunction Endothelium Evidence extrapulmonary tissue heart hypertension in vitro study include individual infecting Long COVID-19 syndrome other tissues outcome pandemic Perspective promote provide respiratory respiratory pathogen respiratory tract SARS-CoV-2 SARS-COV-2 infection susceptibility the SARS-CoV-2 vascular inflammation vasculature virus
[DOI] 10.3389/fcell.2022.824851 PMC 바로가기 [Article Type] Cell and Developmental Biology