In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy CalculationsResearch Article Published on 2020-09-222022-10-29 Journal: mSystems [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome analyzed angiotensin-converting enzyme 2 antiviral properties attribute binding binding free energy binding site biological systems calculation classical computer-aided drug design coronavirus coronavirus disease COVID-19 direct fusion docking drug Drug discovery Dynamics energy evaluated exhibit Features Free free energy fusion fusion peptide fusion protein Host host cell host cell receptor hydrophobic pocket inferences Interaction mechanism membrane molecular molecular docking molecular dynamics Molecular dynamics simulation molecular mechanics/generalized Born model and solvent accessibility pandemic physiological Protein provide rationale reported repositioning repurposing residue residues S2 domain S2 fusion peptide-containing domain SARS-CoV-2 screened selected selected drug severe acute respiratory syndrome coronavirus 2 shown small molecule Small molecules solvent spike Spike protein statistical the S protein the SARS-CoV-2 Trajectories variables virus were used [DOI] 10.1128/mSystems.00382-20 PMC 바로가기 [Article Type] Research Article
Readiness of Small Energy Markets and Electric Power Grids to Global Health Crises: Lessons From the COVID-19 PandemicPower Engineering and Energy Published on 2020-07-132022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] affected caused change changes in coronavirus COVID-19 COVID-19 pandemic Critical deviation energy Energy policy Estonian explained Finnish Frequency global health grid Health Health crisis help identify joint lesson pandemic parameters power power system stability power systems flexibility readiness reduced Renewable energy SARS-CoV-2 stability [DOI] 10.1109/ACCESS.2020.3008929 PMC 바로가기 [Article Type] Power Engineering and Energy
The Impact of Isolation Measures Due to COVID-19 on Energy Intake and Physical Activity Levels in Australian University StudentsArticle Published on 2020-06-232022-10-31 Journal: Nutrients [Category] COVID-19, SARS, [키워드] activity Affect both sexes Care coronavirus disease Course COVID-19 COVID-19 pandemic defined diet early phase eight energy Energy intake enrolled examined exercise female females finding FIVE follow-up study Frequency greater Health Impact impacted intake Isolation Late adolescents Level males measure Measures nutrition pandemic physical physical activity physical activity level recall reduced seeking student survey transitioned university young adults [DOI] 10.3390/nu12061865 PMC 바로가기 [Article Type] Article
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarateα-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화Research Article Published on 2017-08-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while [DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article
Daily consumption of ready-to-use peanut-based therapeutic food increased fat free mass, improved anemic status but has no impact on the zinc status of people living with HIV/AIDS: a randomized controlled trial바로 사용할 수 있는 땅콩 기반 치료 식품을 매일 섭취하면 무지방 질량이 증가하고 빈혈 상태가 개선되지만 HIV/AIDS 감염자의 아연 상태에는 영향을 미치지 않습니다. 무작위 대조 시험Research Article Published on 2016-01-042022-08-09 Journal: BMC Public Health [Category] 임상, [키워드] adjusted Admission affected AIDS Anemia anemic anemic status ART atomic absorption spectrometry Bio-Impedance Analysis Body body composition body fat body weight both groups clinical trial comparable Concentration conducted Control control group Controlled Controlled clinical trial CRP Daily daily recommended intake deficiency discharge energy fat Fat free mass fat-free mass food group hemoglobin HIV/AIDS Hospitalized Improving Individual dietary Infection iron Malnutrition measure muscle mass on admission patients percentage body fat plasma plasma zinc concentration PLWH positive Randomized controlled trial Randomly ready-to-use therapeutic food receive Recommended Dietary Allowances Registered remained Result Senegal severe malnutrition significantly standard hospital diet status sub-Saharan Africa the patient therapeutic Therapeutic food Treatment was determined was measured were measured Zinc zinc deficiency α1-AGP [DOI] 10.1186/s12889-015-2639-8 PMC 바로가기 [Article Type] Research Article
Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection녹농균 급성 화상 및 만성 외과적 상처 감염에 대한 요건Research Article Published on 2014-07-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major accompanied acute and chronic infections acute and chronic P. aeruginosa wound infections acute and non-diabetic chronic wound infections acute burn wound infections acute infection acute infections acute wounds addition amino acids Bacterial bed sores Burn burn wound burn wound infections burns carbon carbon source caused chemotactic chemotaxis chronic chronic and acute wounds chronic infection chronic infections chronic wound chronic wound infections cofactor cofactors colonization complex Critical determinant diabetic ulcers energy expression Fatty acid fatty acids fitness flagellar function Gene Expression Gene expression profiling Genetic genomic growth healthcare high mortality High-throughput sequencing in vivo Infection infections insertion Intensive Intervention metabolic genes murine model murine models mutant non-diabetic chronic wound infection non-diabetic chronic wound infections not correlated nutritional requirements opportunistic infection opportunistic Infections opportunistic pathogen P. aeruginosa P. aeruginosa wound infections pathogen Pathogenesis persistence power primary source profiles Pseudomonas aeruginosa purines Requirement RNA-Seq Sepsis Sequencing Soft tissue Soft tissue infections Spread Strains Surgical Wound Infection These data tissue damage Tn-seq trajectory Transcriptome Travel utility Variation virulence while Wound Infection wound infections [DOI] 10.1371/journal.pgen.1004518 PMC 바로가기 [Article Type] Research Article