enrichment – Page 8 – Communicable Diseases Research

Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19

글리 시르 시리 바 글라브라 추출물을 이용한 식품 농축 래트에서 ACE2 mRNA 및 단백질 발현을 억제합니다.

Article

Published on 2021-07-062022-08-31
Journal: Nutrients [Category] 유전자 메커니즘, 치료제,

KEA3: improved kinase enrichment analysis via data integration

AcademicSubjects/SCI00010

Published on 2021-07-022022-10-31
Journal: Nucleic Acids Research [Category] COVID-19, SARS,

[키워드] cellular co-expression co-occurrence collected database enrichment enrichment analysis examined expected experiment experiments Gene Expression IMPROVE Interaction kinase Phosphoproteomics phosphorylated predict predicted Proteins proteomics responsible Signaling Small molecules substrate supported upstream
[DOI] 10.1093/nar/gkab359 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform

SARS-COV-2 감염에서 L-DOPA 데카르 복실 라제 발현의 변경 및 인터페론-유도 성 ACE2 이소 형과의 연관성

Research Article

Published on 2021-06-292022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술,

[키워드] ACE2 ACE2 expression alteration analyzed antiviral response association cell death cell population co-expressed correlated correlation COVID-19 COVID-19 patient COVID-19 patients cultured virus DDC Effect elevated ENCODE enrichment epithelial cells EPO evaluated expression favor Gene Expression Host host gene expression hours post-infection hypoxia in viral individual individuals infected cells infected individuals infections Influenza influenza-infected patients interferon interferon-stimulated gene isoform L-DOPA mild symptoms mRNA level mRNA levels nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples negatively affected non-infected Patient qPCR quantified receptor Regulation RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 virus SARS-CoV-2-infected cells SARS-CoV-2-infected individuals significantly statistically significant subjects suppresse the SARS-CoV-2 tissue VeroE6 cells Viral viral infection viral infections Viral load virus while whole blood sample
[DOI] 10.1371/journal.pone.0253458 PMC 바로가기 [Article Type] Research Article

The Gut Microbiota of Critically Ill Patients With COVID-19

COVID-19 중환자의 장내 미생물군

Cellular and Infection Microbiology

Published on 2021-06-292022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술,

Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context

COVID-19 환자의 인터루킨-6 수용체 차단: 상황에 따른 임상 시험 적용

Review

Published on 2021-06-012022-09-11
Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] acute respiratory illness binding blockade Characteristics clinical and methodological heterogeneity clinical decision clinical trial concomitant use contributed Corticosteroid Corticosteroids cytokine Decision making Efficacy and safety enrichment Evidence Factor heterogeneity IL-6 IL-6 receptor antagonists implicated interleukin-6 measurement scales methodological outcome Pathogenesis pathogenesis of COVID-19 Patient patients pleiotropic potential benefit potential benefits randomised randomised trials receptor receptor antagonists reported respiratory sarilumab Sery severity severity of illness tested the disease Tocilizumab Treatment treatment effects Trial trials Variability
[DOI] 10.1016/S2213-2600(21)00139-9 PMC 바로가기 [Article Type] Review

Enrichment of CCR6 + CD8 + T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19

COVID-19 환자의 폐에서 CCR6 + CD8 + T 세포 및 CCL20 농축

Article

Published on 2021-06-012022-09-12
Journal: European Journal of Immunology [Category] MERS, SARS, 진단,

[키워드] BALF CCL20 Ccr6 CD8 CD8 T cell Cell COVID-19 COVID-19 patients CXCR3 enrichment expression Immunity Ligand lung mechanically ventilated mechanically ventilated patient Patient T cell T cells with COVID-19
[DOI] 10.1002/eji.202049046 PMC 바로가기 [Article Type] Article

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

인간 질병과 분자 표현형의 공유 유전 구조를 연결하는 아틀라스는 COVID-19 감수성에 대한 통찰력을 제공합니다

Software

Published on 2021-05-172022-09-10
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘,

[키워드] ABO Analysis application association Bacterial infection Biomarker calculate capture CD209 cellular clinical utility Colocalization common diseases complex COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 susceptibility Cross-phenotype association database DC-SIGN demonstrated Diseases DPP9 driven by enrichment examined explain exploration facilitate fibrosis genetic architecture Genetic variation genome-wide association glycosylation Gout GWAS GWAS summary statistics healthy control healthy controls Hi-HOST human disease human diseases hypothese hypotheses identify Idiopathic pulmonary fibrosis information LD-score lead Linkage disequilibrium locus Macular telangiectasia mechanism molecular molecular phenotype overlap pathophysiology Peripheral blood Phenotypes phenotypic PheWAS plasma protein Pleiotropy portal provide pulmonary fibrosis receptor regulate reported Result rs12610495 rs2869462 rs505922 SARS-CoV-2 severe COVID-19 SIGN SNP supplementary material therapeutic approaches traits transcriptomics translation while
[DOI] 10.1186/s13073-021-00904-z PMC 바로가기 [Article Type] Software

Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19

메타게놈 분석, COVID-19 환자의 구강인두 미생물총 변화 밝혀

Article

Published on 2021-05-132022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 치료기술, 치료제,

[키워드] Acinetobacter addition alteration Amino acid amino acid metabolism Analysis antimicrobial resistance AUC BALF Biomarker Biomarkers Characteristics characterized Classifier Co-infection correlated COVID-19 COVID-19 group COVID-19 patient COVID-19 patients COVID-19 severity critical cases Depletion disease severity elevated enrichment exhibited flu functional genus Health health problem healthy control healthy controls induce Infection Inflammatory response Influenza influenza B Klebsiella lung Lungs marker metabolism metagenomic sequencing microbe microbial Microbiology Microbiome microbiota natural reservoir neutrophil–lymphocyte ratio NLR Opportunistic Pathogens oral cavity Oropharyngeal oropharynx pathogen Pathogens Patient patients patients with COVID-19 resistance gene reveal severity significant enrichment significantly Streptococcus susceptibility swab specimen systemic inflammation with COVID-19
[DOI] 10.1038/s41392-021-00614-3 PMC 바로가기 [Article Type] Article

Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates

유전적으로 조절된 유전자 발현과 약리학적 라이브러리의 통합은 치료 약물 후보를 제공합니다

Article

Published on 2021-04-262022-09-11
Journal: Human molecular genetics [Category] 신약개발, 유전자 메커니즘,

Prostate adenocarcinoma and COVID‐19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS‐CoV‐2

전립선 선암종 및 COVID-19: SARS-CoV-2에 대한 감수성에서 TMPRSS2 발현의 가능한 영향

Original Article

Published on 2021-02-202022-09-10
Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] androgen Cancer cancer cell cancer patient Cancer patients carcinoma cellular protease Clinical severity Colon conducted COVID‐19 COVID‐19 domains enrichment expresse expressed expression expression profile expression profiles facilitate followed by functional functional annotation highest highlighting host cells Impact increased expression Influenza influenza A involved isoform lung mechanism OMIM organs outcome overexpression pancreas pandemic Pathogenesis pathway Pathways Patient patients physiological play roles predict promoter Prostate prostate adenocarcinoma Prostate cancer prostate gland Protective Protein Regulation salivary salivary gland SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 seminal vesicle Serine small intestine stomach Structure survival susceptibility the disease Therapeutic strategies therapeutic strategy tissue tissues TMPRSS2 TMPRSS2 expression TMPRSS2 gene transcriptional trypsin tumorigenesis Vesicle Viral viral entry virus viruses
[DOI] 10.1111/jcmm.16385 PMC 바로가기 [Article Type] Original Article