Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course AnalysisObservational Study Published on 2021-12-092022-10-04 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] addition Admission Analysis Bacterial sepsis Cell cellular circulating Clinical outcome clinical outcomes Cohort Course COVID patient Critically ill patient dyscrasia elevated ELISPOT enzyme-linked immunospot assay etiology Ex vivo exhibited expression functional healthy control HLA-DR hospitalized patient IFN-gamma immune immune response Immune suppression immunological Immunosuppression incidence Infection Inflammation Inflammatory marker initial less leukocyte MDSC mononuclear cell organ dysfunction patients physiologic derangement plasma biomarker reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient secondary bacterial infection Secondary infection secondary infections severe SARS-CoV-2 significantly higher subjects suffered suppressed time TNF-alpha [DOI] 10.3389/fimmu.2021.792448 PMC 바로가기 [Article Type] Observational Study
Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in AsthmaImiquimod는 인터페론 반응을 높이고 ACE2 및 천식에서 인간 기관지 상피의 염증 반응을 감소시킵니다Immunology Published on 2021-12-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] ACE2 ACE2 expression analyses Analysis analyzed Anti-inflammatory Anti-viral anti-viral cytokine anti-viral cytokines anti-viral drug Anti-viral treatment Asthma asthmatic Asthmatic patients baseline bronchial bronchial epithelial cell COVID-19 COVID-19 infection cytokine cytokine signaling Cytokines decrease donors drug dsRNA dual Effect ELISA epithelial epithelial cells epithelium Ex vivo examined exhibit expression feasibility HBEC HBECs healthy highlight Human IFN signaling IFN-β IL-1β IL-33 IL-6 IL-8 imiquimod IMPROVE infections involved mechanism mRNA multiplex objective pathway poly(I:C poly(I:C) pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines producing protective effect proteomic qPCR Receptor binding reduced reducing resistance mechanisms response Result RT-qPCR SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Severe COVID-19 Infection SP1 spike-protein stimulated subjects suppression target TLR7 TLR7 agonist Tolerance treat Treatment Trigger triggers Viral viral infection viral infections Viral resistance western blot [DOI] 10.3389/fimmu.2021.743890 PMC 바로가기 [Article Type] Immunology
Recovery of Memory B-cell Subsets and Persistence of Antibodies in Convalescent COVID-19 Patients회복기 COVID-19 환자에서 기억 B 세포 하위 집합의 회복 및 항체 지속성Article Published on 2021-11-272022-09-12 Journal: The American Journal of Tropical Medicine and Hygi [Category] 진단, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antibody Response Atypical B cell B cells B-cell cells central memory Chain Reaction classical convalescent individual convalescent individuals Coronavirus-2 COVID-19 Ex vivo examined exhibited frequencies Frequency group Humoral immunity IgG immature immune response individuals with COVID-19 Infection Longevity memory B cell memory B cells memory B-cell Mild Modification modifications naïve B cells naive cells Neutralizing antibodies neutralizing antibody Patient persistence Plasma cell Plasma cells polymerase chain polymerase chain reaction SARS-CoV-2 SARS-COV-2 infection Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 subset with COVID-19 [DOI] 10.4269/ajtmh.21-0883 PMC 바로가기 [Article Type] Article
Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial CellsPharmacology Published on 2021-11-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 ACE2 expression ACEi ACEIs AEC Air-liquid interface airway airway epithelial cell airway epithelium Angiotensin II angiotensin II (A II) receptor antagonists angiotensin-converting eitzyme inhibitors angiotensin-converting enzyme 2 antagonist antagonists ARB binding Biosafety Level 3 BSL-3 Captopril cardiovascular system Cell cells change changed children Clinical data convert Culture culture media cultures disease Effect epithelium Ex vivo expression generate IFN IFNB1 IFNL2 IL-1B IL-6 Infection infection with SARS-CoV-2 inhibitors interferon kidney losartan medication modify modulate MOI multiplicity of infection not significantly different poor prognosis Proinflammatory cytokine protective effect Protein qPCR quantitative PCR receptor reduce Replication responses risk risk of COVID-19 RNA SARS-CoV-2 SARS-CoV-2 replication SARS—CoV—2 significantly the SARS-CoV-2 treated Treatment type I USA-WA1/2020 viral spike protein were assessed were infected with COVID-19 [DOI] 10.3389/fphar.2021.765951 PMC 바로가기 [Article Type] Pharmacology
Allelic variation in class I HLA determines CD8 + T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2Research Articles Published on 2021-11-182022-11-01 Journal: Science Immunology [Category] COVID-19, [키워드] alleles Antigen applied CD8 Cell condition cross-reactive description determine disease stage epitope Ex vivo feature generate Genotype HLA HLA class I HLA variation immune Immunological memory memory response memory T reactive reactivity recall required SARS-CoV-2 SARS-COV-2 infection sequence significantly single-cell Single-cell transcriptomics specificity T cell T cell phenotype T cell response T cells TCR Variation [DOI] 10.1126/sciimmunol.abk3070 PMC 바로가기 [Article Type] Research Articles
Probiotics Regulating Inflammation via NLRP3 Inflammasome Modulation: A Potential Therapeutic Approach for COVID-19Review Published on 2021-11-172022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 adaptive Bacterial cellular damage clinical trial COVID-19 COVID-19 pathogenesis cytokine release cytoplasmic dosage Effect Effectiveness Evidence Ex vivo forms highlighting host’s immune system Human immune response immune systems immunomodulatory implicated in vivo indicate inflammasome activation inflammasomes inflammation markers inflammatory conditions inflammatory process Invasion mammalians management metabolites microbial infection modulate multiprotein complex NLRP3 NLRP3 activation NLRP3 inflammasome pathophysiological mechanism Potential preclinical study presenting probiotic bacteria Probiotics protein 3 Regulating Regulation Replication Research SARS-CoV-2 SARS-COV-2 infection shown strain trials virus with COVID-19 [DOI] 10.3390/microorganisms9112376 PMC 바로가기 [Article Type] Review
Selective Lobe Ventilation and a Novel Platform for Pulmonary Drug Delivery선택적 엽 환기 및 폐 약물 전달을위한 새로운 플랫폼Review Published on 2021-11-012022-08-31 Journal: Journal of cardiothoracic and vascular anesthesia [Category] MERS, SARS, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome alveolar recruitment cause caused Clinical practice Compliance Complication Continuous Positive Airway Pressure coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 death delivery double-lumen tube drug End-Expiratory Pressure Ex vivo expected gravity heterogeneity heterogeneous heterogeneous lung disease implementation in vitro in vivo initial lobar lobar ventilation lobe lobe ventilation lobes lower lobe lower lobes lung Lung disease Lung diseases Lung injury mechanical ventilation novel platform positive airway pressure Positive end-expiratory pressure potential benefit potential benefits Prevent provide pulmonary pulmonary drug delivery recruitment regional ventilation respiratory distress Respiratory distress syndrome selective severe acute respiratory distress syndrome split ventilation syndrome therapeutic option therapy Ventilation ventilator ventilator parameter ventilator parameters Ventilator-induced lung injury [DOI] 10.1053/j.jvca.2021.04.041 PMC 바로가기 [Article Type] Review
Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19조직병리학적 평가는 치명적인 COVID-19 환자의 망막 혈관 변화, 염증 및 신경교증을 나타냅니다Inflammatory Disorders Published on 2021-10-292022-09-11 Journal: Graefe's Archive for Clinical and Experimental Oph [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] abnormality age-matched control Analysis assessment caused change changes changes in choroid controls COVID-19 COVID-19 infection COVID-19 infections COVID-19 samples density determine Donor donors Effect evaluated Ex vivo eye eyes Fundus gliosis hemorrhage hemorrhages Hemorrhagic histology histopathological Histopathology immunocytochemistry indicated Infection Inflammation macroscopic Macula marker negative test ocular Patient processed provide rationale Region Result Retina SARS-CoV-2 SARS-COV-2 infection Seven statistically significant supplementary material the SARS-CoV-2 tissue Vascular vasculature virus vitreous were assessed whole mount [DOI] 10.1007/s00417-021-05460-1 PMC 바로가기 [Article Type] Inflammatory Disorders
Generation and Effect Testing of a SARS-CoV-2 RBD-Targeted Polyclonal Therapeutic Antibody Based on a 2-D Airway Organoid Screening SystemImmunology Published on 2021-10-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome airway Airway organoids anti-RBD approved binding caused coronavirus Coronavirus disease 2019 COVID-19 develop domain Drug screening drugs Effect effective Efficacy Emergency use authorization epithelial Epitopes Ex vivo Generation immune in vivo Infection injection intrinsic morphology mouse model Mutation mutations Organoid polyclonal antibody Potential potential therapy Receptor-binding domain respiratory infectious disease Respiratory tract infections SARS-CoV-2 SARS-COV-2 infection Screening serum Side effect Side effects spread of COVID-19 System tested Testing tissue damage Treatment two-dimensional US FDA Vaccine viral escape viral infection viral neutralization viral strain virus [DOI] 10.3389/fimmu.2021.689065 PMC 바로가기 [Article Type] Immunology
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infectionArticle Published on 2021-10-042022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome Anti-viral antivirals Apoptosis Brain can be used cause caused cell death Central nervous system characterized complex compounds COVID-19 Culture Evidence Ex vivo global pandemic granular hamster immune response induce infect Infection innate immune response Interaction interferon Local lung lung tissue necroptosis neurological neurons offer organ pyroptosis SARS-CoV-2 spread to tissue pathology unique viral infection viral pathogenesis viral tropism virus [DOI] 10.1038/s41467-021-26096-z PMC 바로가기 [Article Type] Article