A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1게놈 전체의 연관성 연구는 EFEMP1 유전자 내에서 2p16.1의 담도 폐쇄증에 대한 감수성 유전자좌를 확인합니다.Research Article Published on 2018-08-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis Anomaly association Author bile ducts Biliary atresia Cell cell proliferation cell type cell types characterized cholestasis cirrhosis Cohort cohorts Combination complex composed Control controls demonstrated disease disease manifestation Diseases disorder EFEMP1 elevated ENCODE etiology expressed expression Extracellular Extracellular matrix Factor fibroblast fibrosis genetic loci genetic risk factor genetic risk factors Genome Genome wide association study Genome-wide association study genome-wide significant GWAS human liver Hypothesis identify immunohistochemistry implicated increase in independent infectious Inflammatory intron liver liver failure livers locus matched controls mechanism Meta-analysis organogenesis Patient pediatric performed portal Protein responsible RNA expression secreted smooth muscle SNP SNPs specimen susceptibility susceptibility loci transcript two group two groups vascular smooth muscle vascular smooth muscle cells was performed [DOI] 10.1371/journal.pgen.1007532 PMC 바로가기 [Article Type] Research Article
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크Research Article Published on 2017-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes [DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article
The role of serum hyaluronic acid determination in the diagnosis of liver fibrosisReview Published on 2017-01-012023-06-19 Journal: Acta biochimica Polonica [Category] B형 간염, [키워드] cirrhosis Extracellular matrix fibrosis Hepatitis Hyaluronic acid non-invasive marker [DOI] 10.18388/abp.2016_1443 [Article Type] Review
The role of biofilms in onychomycosis손발톱진균증에서 생물막의 역할journal-article Published on 2016-06-012024-07-28 Journal: Journal of the American Academy of Dermatology [Category] 백선증, [키워드] Antifungal biofilm dermatophyte fungi Extracellular matrix Nail Onychomycosis [DOI] 10.1016/j.jaad.2016.01.008 [Article Type] journal-article
Vascular patterns provide therapeutic targets in aggressive neuroblastic tumorsResearch Paper Published on 2016-04-122023-08-29 Journal: Oncotarget [Category] E형 간염, [키워드] blood vessels Capillaries Extracellular matrix Neuroblastoma sinusoids [DOI] 10.18632/oncotarget.7661 PMC 바로가기 [Article Type] Research Paper
Comparative Biology of the Pentraxin Protein Family: Evolutionarily Conserved Component of Innate Immune System펜트락신 단백질 가족의 비교 생물학: 선천 면역 시스템의 진화적으로 보존된 구성 요소book-chapter Published on 2015-01-012024-08-04 Journal: International Review of Cell and Molecular Biology [Category] 폐렴구균 감염증, [키워드] C-reactive protein complement system CRP receptor Extracellular matrix innate immune system lipopolysaccharide opsonization Pentraxin. [DOI] 10.1016/bs.ircmb.2015.01.002 [Article Type] book-chapter
Proteome Profile of Swine Testicular Cells Infected with Porcine Transmissible Gastroenteritis CoronavirusResearch Article Published on 2014-10-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Alpha Analysis analyzed approach biological processes caspase-8 Cell cells cellular change complex conducted coronavirus determine developmental expression expression level Extracellular matrix gastroenteritis growth growth factor Heat shock help host cell immune system Infection Interaction knowledge maturation mechanism metabolite neurological system occur Ontology Pathogenesis post infection precursor profile Protein protein complex protein level Proteins proteomic provide quantitation Quantitative Signaling significant changes in Stage Stress Testicular TGEV TGF-β1 two-dimensional viral infection virus Virus-host interactions Western blot analysis [DOI] 10.1371/journal.pone.0110647 PMC 바로가기 [Article Type] Research Article
The Choline-binding Protein PspC of Streptococcus pneumoniae Interacts with the C-terminal Heparin-binding Domain of Vitronectin폐렴렙토코커스 폐렴의 콜린 결합 단백질 PspC는 비트로넥틴의 C-말단 헤파린 결합 도메인과 상호 작용합니다.journal-article Published on 2013-05-012024-08-04 Journal: Brain stimulation [Category] 폐렴구균 감염증, [키워드] adhesin Bacterial pathogenesis complement Extracellular matrix pneumococci protein-protein interactions PspC surface plasmon resonance (SPR) virulence factors [DOI] 10.1074/jbc.M112.443507 [Article Type] journal-article
Application of tissue engineering to the immune system: development of artificial lymph nodesArticle Published on 2012-11-162023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] bio-materials Extracellular matrix Lymph node stroma tissue engineering [DOI] 10.3389/fimmu.2012.00343 PMC 바로가기
Tetraspanin Is Required for Generation of Reactive Oxygen Species by the Dual Oxidase System in Caenorhabditis elegansTetraspanin은 Caenorhabditis elegans의 이중 산화 효소 시스템에 의한 반응성 산소 종의 생성에 필요합니다Research Article Published on 2012-09-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition aerobic aerobic metabolism aging Analysis association Author biosynthetic biosynthetic pathway Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans cause Cell cell surface cellular cellular component cellular components co-expression collagen Combination complex complexes conjunction conserved Defense deficiency demonstrated dependent on disease DOXA dual elegan enzyme Enzymes Evidence experiment exposure to Extracellular matrix failure functions Generation Genetic genetic mutation genetics Host host defense hydrogen hydrogen peroxide Imbalance Immunity in vitro in vivo inhibit isozyme less lipids mammalian cells mammals maturation mechanism member metabolism modifications mucosal mutant mutants Mutation NADPH NADPH oxidase nucleic acids Oxidase oxidative stress oxygen pathway peroxidase physiological produced Protein provide Radiation reactive reactive oxygen species redox state regulated Regulatory required responsible restored ROS Signaling signaling pathway Specy suggested System tetraspanin the cell Thyroid thyroid hormone toxic tyrosine unique UV light [DOI] 10.1371/journal.pgen.1002957 PMC 바로가기 [Article Type] Research Article