Identification of the RNase-binding site of SARS-CoV-2 RNA for anchor primer-PCR detection of viral loading in 306 COVID-19 patients306명의 COVID-19 환자에서 앵커 프라이머-PCR 검출을 위한 SARS-CoV-2 RNA의 RNase 결합 부위 식별Multicenter Study Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anchor primer bioinformatics Bioinformatics analysis bioinformatics analysis. Chain Reaction confirmed case confirmed cases convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cycle threshold value demonstrated Diagnosis feces first positive Gender identification IMPROVE male molecular Molecular diagnosis N gene nasal nuclear Older age ORF ORF gene pandemic Pharyngeal swab polymerase chain polymerase chain reaction primer reveal RNA RNase SARS-CoV-2 SARS-CoV-2 RNA sensitivity severe acute respiratory syndrome Coronavirus sputum stability supported Urine Viral RNA [DOI] 10.1093/bib/bbaa193 PMC 바로가기 [Article Type] Multicenter Study
Repeated SARS-CoV-2 Positivity: Analysis of 123 CasesBrief Report Published on 2021-03-192022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis baseline characteristics case reports case sery coronavirus coronavirus disease Course COVID-19 Critical Critical disease Descriptive analysis evaluate evaluated expected Factor first positive interval item New coronavirus Patient patient data patients PCR performed polymerase chain polymerase chain reaction positive predict predominant Reinfection repeated Reporting review SARS-CoV-2 SARS-CoV-2 positivity severe disease course severity systematic literature search systematic review [DOI] 10.3390/v13030512 PMC 바로가기 [Article Type] Brief Report
Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study우려되는 SARS-CoV-2 변이체에 감염된 환자의 사망 위험 202012/1: 일치 코호트 연구Research Published on 2021-03-102022-09-10 Journal: The BMJ [Category] Fulltext, SARS, 변종, 진단, 치료기술, [키워드] 95% confidence interval age argument circulating SARS-CoV-2 variants circulating variant circulating variants cohort study Community death Deprivation detectability Ethnicity first positive hazard ratio impacted increase in increased mortality index infected with SARS-CoV-2 Infection International Local low risk group Matched measure Mortality National objective outcome measure participant Patient pillar populations positive Probability reduce Result risk SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 variants setting Sex specimens Spike protein TaqPath test result tested the spike protein variant variant of SARS-CoV-2 VOC-202012/01 with infection [DOI] 10.1136/bmj.n579 PMC 바로가기 [Article Type] Research
Longitudinal follow-up of IgG anti-nucleocapsid antibodies in SARS-CoV-2 infected patients up to eight months after infectionSARS-CoV-2 감염 환자에서 감염 후 최대 8개월까지 IgG 항-뉴클레오캡시드 항체의 종단 추적Multicenter Study Published on 2021-03-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료법, [키워드] Abbott anti-N IgG anti-nucleocapsid antibody antibodies antibody antibody level antibody levels Architect collected coronavirus COVID-19 Critical decrease develop eight first positive Follow-up hospitals IgG IgG antibodies IgG antibody immunoassay Immunoglobulin Immunoglobulin G Infection longitudinal Longitudinal studies Mild mild patient mild patients moderate MOST patients PCR PCR-confirmed positive remained retrospective SARS-CoV-2 SARS-CoV-2 infected patient seroconverted seronegative severe COVID-19 severe COVID-19 patients Severe patient severe patients shown significantly higher significantly lower steadily decreased symptom onset university was performed were measured windows within 6 months [DOI] 10.1016/j.jcv.2021.104765 PMC 바로가기 [Article Type] Multicenter Study
Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health AdministrationResearch Article Published on 2021-02-112022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 30-Day mortality 95% CI Aspirin Care clinically Cohort common contribute correlation country COVID-19 COVID-19 mortality COVID-19 patient COVID-19 positive patient database decrease decreased mortality demonstrated diagnosed with COVID-19 Evidence finding first positive Health implication inflammatory pathway lab medication mitigate Mortality National overall mortality Pathways Patient Patient care polymerase chain positive pre-diagnosis Prospective required retrospective severity of COVID-19 significant decrease statistically thrombotic veteran veterans [DOI] 10.1371/journal.pone.0246825 PMC 바로가기 [Article Type] Research Article
Time to SARS‐CoV‐2 clearance among patients with cancer and COVID‐19Original Research Published on 2021-02-092022-10-31 Journal: Cancer Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Cancer Cancer center cancer patient Cancer patients Cancer therapy Care CDC CDC criteria center Chemotherapy clearance clinical clinical criteria Cohort Control coronavirus coronavirus disease COVID‐19 COVID‐19 criteria expected extension first positive hospital Infection infection control less median median time nasopharyngeal Patient Patients with cancer polymerase chain positive precautions prevention Result retrospective cohort study RT‐PCR SARS‐CoV‐2 Society Symptoms the median time transcriptase [DOI] 10.1002/cam4.3708 PMC 바로가기 [Article Type] Original Research
Development and validation of a prognostic COVID-19 severity assessment (COSA) score and machine learning models for patient triage at a tertiary hospitalResearch Published on 2021-02-052022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, [키워드] Accuracy acute respiratory syndrome Admission Algorithm artificial intelligence assist AUROC automated Bern C-reactive protein Care characteristic clinical clinical outcomes clinical risk comparable composite endpoint contribute coronavirus COVID-19 severity Critical illness death demographic data development first positive glomerular filtration rate Glucose group Health hemoglobin hospital Hospitalization intensive care Laboratory leucocyte machine learning model ML model Negative predictive value outcome parameters Patient patient triage performed positive Positive predictive value predict Predictive prognostic resources Result risk risk score risk stratification SARS-CoV-2 sodium statistical learning Stratification Support Switzerland Test tested training data validation cohort were used [DOI] 10.1186/s12967-021-02720-w PMC 바로가기 [Article Type] Research
Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USAExpedited Published on 2021-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Contact coronavirus coronavirus 2 coronavirus disease COVID-19 first positive had no household contacts household transmission hygiene infection control investigated less measure median Mild nonspecific occur Patient patients Person positive progression respiratory respiratory infections reverse transcription PCR SARS virus SARS-CoV-2 self-isolate severe acute respiratory syndrome coronavirus 2 shedding specimen Symptom symptom onset tested Transmission USA Utah viral shedding Virus shedding viruses were infected zoonoses [DOI] 10.3201/eid2702.203517 PMC 바로가기 [Article Type] Expedited
Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across SpainSARS-CoV-2 감염이 의심되어 병원에 입원한 환자의 항체 반응: 스페인 전역의 다기관 연구 결과Multicenter Study Published on 2021-01-292022-09-10 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, 진단, 치료법, [키워드] antibody Clinical management COVID COVID-19 COVID-19 patient Diagnosis diagnostic test diagnostic tests ELISA kit evaluate evaluated first positive hospital Hospitalization IgA IgA response IgA responses IgG IgG and IgM IgG antibodies IgM multicenter multicenter study nucleoprotein pandemic Patient PCR PCR test positive Result SARS-CoV-2 sensitivity Serological assay serological assays serological response Spain Spanish Spike protein Support the patient Viral viral spike protein were measured were used [DOI] 10.1007/s10096-020-04139-5 PMC 바로가기 [Article Type] Multicenter Study
Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patientsLetter to the Editor Published on 2021-01-272022-10-31 Journal: Experimental Hematology & Oncology [Category] COVID-19, [키워드] acute respiratory syndrome Admission Antibody Response B cell basophil caused cell count cells clearance Cohort coronavirus Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patient COVID-19 patients criteria CRP discharge first positive IgG antibody IgM/ IgG antibody IgM/IgG IL-6 Infection Inflammation innate immune cell Killer cell Lymphocyte count Lymphocyte subset Lymphocytes lymphocytopenia Mortality Nasopharyngeal swab natural natural killer cell Neutrophils NK cell non-severe group oropharyngeal swabs parameter Patient Peripheral blood platelets counts respiratory symptom RNA viral shedding SARS-CoV-2 SARS-CoV-2 viral RNA serum cytokine severe group significant difference significantly significantly lower specimens survival rate T cells therapy Treatment upper respiratory tract viral disease Viral RNA viral shedding White blood cells [DOI] 10.1186/s40164-021-00199-1 PMC 바로가기 [Article Type] Letter to the Editor