High-throughput virtual screening of drug databanks for potential inhibitors of SARS-CoV-2 spike glycoproteinSARS-COV-2 스파이크 당 단백질의 잠재적 억제제에 대한 약물 데이터 뱅크의 고 처리량 가상 스크리닝Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] ACE2 ADME approved best binding binding energy C terminal caused chidamide complexes Compound COVID-19 docking domain ebastine effort FDA approved drug flexible in silico Approach indacaterol individual inhibitors of SARS-CoV-2 interact Interaction interactions investigated Ligand MD simulation MD simulations molecular molecular dynamics Novel coronavirus performed potential inhibitors protein-ligand protein-ligand interaction recorded regorafenib SARS-CoV-2 silodosin SMD spike glycoprotein Spread stability Steered molecular dynamics subunit target tasosartan the RBD treat Viral viral RBD viral S viral S protein viral spike Virtual screening virus [DOI] 10.1080/07391102.2020.1835721 PMC 바로가기 [Article Type] Article
Establishing CREATE: lessons learned in setting up a training environment for early-career researchers in respiratory medicineResearch Published on 2022-03-012022-10-28 Journal: BMC Medical Education [Category] Coronavirus, MERS, SARS, [키워드] association Australia clinician Cohort Community COVID-19 distribution Early-career Establishing FIVE flexible Genetic Health Health and medical research IMPROVE include involved Laboratory lesson Medical Research Council National offered participant Patient professional development Program promote provided pulmonary pulmonary fibrosis Research researcher researchers Result seeking Seven supplementary material supported training translational Travel unique [DOI] 10.1186/s12909-022-03169-1 PMC 바로가기 [Article Type] Research
Technical procedures and REDCap tools for internet-based clinical trials인터넷 기반 임상 시험을 위한 기술 절차 및 REDCap 도구Article Published on 2022-03-012022-09-11 Journal: Contemporary clinical trials [Category] 임상, [키워드] Automation capture clinical clinical trial clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 Data base management feature flexible Hydroxychloroquine Patient-oriented research Pragmatic Prophylaxis REDCap researcher Support survey Technical procedure Treatment Trial trials [DOI] 10.1016/j.cct.2021.106660 PMC 바로가기 [Article Type] Article
Conformational variability of loops in the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질 루프의 구조적 가변성Article Published on 2022-03-012022-09-11 Journal: Proteins [Category] SARS, 변종, [키워드] Accuracy Analysis applied binding Characteristics Cluster cluster analysis conformation conformational conformational ensembles conformations COVID-19 decoy selection facilitate flexible identify involved loop loop modeling Protein Protein binding Protein Data Bank protein structure protein structure prediction Region SARS-CoV-2 spike sequence sequence variants. Spike protein structures targets the S protein the SARS-CoV-2 Variability variants viral infection while [DOI] 10.1002/prot.26266 PMC 바로가기 [Article Type] Article
Effects of a remote, YouTube-delivered exercise intervention on young adults’ physical activity, sedentary behavior, and sleep during the COVID-19 pandemic: Randomized controlled trialRandomized Controlled Trial Published on 2022-03-012022-10-05 Journal: Journal of sport and health science [Category] 임상, [키워드] 1:1 adjusted aerobic age analysis of variance body mass index clinically control group Controlled trial coronavirus disease COVID-19 Effect effect size Efficiency examined Exercise intervention flexible Frequency Health help High-intensity interval training improvement interaction effect Intervention intervention group intrinsic measure National outcome pandemic physical activity Primary outcome promote Public Questionnaires Randomized Regulation Resistance-training secondary outcome Sedentary behavior Self-determination Self-determination theory significance level sleep quality social media statistically significant statistically significant difference video [DOI] 10.1016/j.jshs.2021.07.009 PMC 바로가기 [Article Type] Randomized Controlled Trial
Cross-Country Student Perceptions about Online Medical Education during the COVID-19 PandemicArticle Published on 2022-02-282022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] activity addition changes in conducted COVID-19 COVID-19 pandemic creating disadvantage distance-learning education FIVE flexible Hungary improvement interview investigated Japan Japanese lack medical education MOST Norway pandemic Perception positive problem Research SARS-CoV-2 Slovakia student thematic analysis Undergraduate while [DOI] 10.3390/ijerph19052840 PMC 바로가기 [Article Type] Article
Patients’ preferences for telemedicine versus in-clinic consultation in primary care during the COVID-19 pandemicResearch Article Published on 2022-02-222022-10-28 Journal: BMC primary care [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] analyzed asked attribute Combination COVID-19 COVID-19 pandemic described discrete choice experiment evaluate Evidence experiment facilitate flexible groups Healthcare provider hybrid Hybrid primary care implementation increasingly interview literature review Medicine Patient Patient care patients Patients’ preferences preference preferences primary care provide Result rigor seeking selected severity supplementary material Telemedicine the patient thematic analysis understanding was used while [DOI] 10.1186/s12875-022-01640-y PMC 바로가기 [Article Type] Research Article
The impact of COVID-19 on the well-being, education and clinical practice of general practice trainees and trainers: a national cross-sectional studyResearch Published on 2022-02-192022-10-28 Journal: BMC Medical Education [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] activities activity Care change changed Clinical practice COVID-19 COVID-19 pandemic cross-sectional Descriptive statistics education flexible General practice general practitioner Health care organization help Infectious disease measure medical education mental health MOST National pandemic participated performed Practice qualitative data Quantitative data question reducing reported required Result Stress Study design supplementary material Support telehealth thematic analysis was used Workplace learning [DOI] 10.1186/s12909-022-03174-4 PMC 바로가기 [Article Type] Research
Capturing a Crucial ‘Disorder-to-Order Transition’ at the Heart of the Coronavirus Molecular Pathology—Triggered by Highly Persistent, Interchangeable Salt-BridgesArticle Published on 2022-02-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anionic appear arginine baseline being binding catalytic cationic characteristic cleavage site coronavirus COVID-19 disorder disorder-to-order transition enthalpy entropy compensation entropy arrest events Evolution feature FLCS flexible furin cleavage Genome heart homologous Host increase in Interaction interactions Lineage Molecular pathology motif multiplicity offer persistent polybasic Protein proteolytic proteolytic cleavage residue respiratory viral diseases respiratory viruses S1/S2 junction salt-bridge salt-bridge dynamics SARS-CoV SARS-CoV-2 spike Spike–Furin interaction the SARS-CoV-2 Transmissibility [DOI] 10.3390/vaccines10020301 PMC 바로가기 [Article Type] Article
Implementation of a Rapid RT-LAMP Saliva-Based SARS-CoV-2 Testing Program in the WorkplaceCase Report Published on 2022-02-122022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] added Asymptomatic COVID-19 diagnostics employee flexible Group testing heat-inactivated household contact individual isothermal amplification microorganisms non-infectious Non-invasive occupational health and safety ORF1ab performed positive pre-symptomatic Program provided qRT-PCR Rapid rapid molecular testing reduced reverse transcription risk RNase P RT-LAMP Saliva SARS-CoV-2 SARS-COV-2 infection second wave self-administration test tested Testing the SARS-CoV-2 Transmission turnaround times Workplace [DOI] 10.3390/diagnostics12020474 PMC 바로가기 [Article Type] Case Report