Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19
중증 COVID-19 환자의 폐에서 GM-CSF를 발현하는 조직 상주 기억 유사 T H 17 세포의 클론 확장 및 활성화
Research Article
[키워드] Activation
acute respiratory distress
acute respiratory distress syndrome
Analysis
Autoimmune diseases
Bacterial
bacterial pneumonia
BAL
Blood
Bronchoalveolar lavage
Bronchoalveolar lavage fluid
CD8
Cell
cell type
cells
cellular
characterized
Clinical course
clonal expansion
clone
Cohort
cohort of patient
collected
contribute
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 pneumonia
CSF2
cytokine
cytokine expression profile
disease severity
elevated
expressing
feature
Generation
GM-CSF
helper
high mortality
hyperinflammation
identify
IL-17A
IL17A
Immune cell
immune cell type
immune cells
immune response
Immunopathogenesis
interactome
investigated
involved
lung
lung damage
Lung injury
Lung pathology
lung tissue
Lungs
Macrophage
macrophages
mechanism
memory T cell
moderate disease
pathogenic
Patient
patients with COVID-19
Pneumonia
protein level
pulmonary T
respiratory distress
Respiratory distress syndrome
serum
severe coronavirus disease
severe COVID-19
Severe COVID-19 pneumonia
single-cell
subsequent
syndrome
T cell
T cell response
T cells
T helper
TCR
Th17 cells
Therapies
tissues
Transcriptome
Viral
viral clearance
viral infection
[DOI] 10.1126/sciimmunol.abf6692 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1126/sciimmunol.abf6692 PMC 바로가기 [Article Type] Research Article