healthy individuals – Page 8 – Communicable Diseases Research

Dysregulation of RNA interference components in COVID-19 patients

Research Note

Published on 2021-10-292022-10-27
Journal: BMC Research Notes [Category] COVID-19,

Dysregulation of RNA interference components in COVID-19 patients

Research Note

Published on 2021-10-292022-10-27
Journal: BMC Research Notes [Category] Coronavirus, COVID-19, MERS, SARS,

Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients

심혈관 환자에서 SARS-CoV-2 세포 수용체 ACE2 수준의 변화: COVID-19 환자 계층화를 위한 잠재적 바이오마커

Original Article

Published on 2021-10-212022-09-11
Journal: GeroScience [Category] MERS, SARS, 바이오마커,

[키워드] ACE2 ACE2 expression ACEi activities activity affected angiotensin Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 Biomarker blood pressure cardiovascular disease cardiovascular diseases cardiovascular status cellular entry cellular receptor change circulating Comorbidity Compliance controls COVID-19 COVID-19 patient Effect Ejection fraction elevated ELISA enzyme enzyme activity healthy individuals heart failure Heart transplantation human serum hypertension hypertensive hypertensive patients individual inhibitory left left ventricle left ventricular ejection fraction lung lung cancer lung tissue male Male sex medication medications Mortality negative correlation no correlation obese Older overweight Pathomechanism Pathomechanisms Patient patients RAAS inhibitors RAS renin-angiotensin-aldosterone system (RAAS) SARS-CoV-2 serum severe COVID-19 severity Sex Stratification subject the SARS-CoV-2 Thoracic Thoracic Surgery tissue Treatment Ventricle ventricular ventricular ejection was increased without affecting
[DOI] 10.1007/s11357-021-00467-2 PMC 바로가기 [Article Type] Original Article

Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans

건강한 성인에서 SARS-CoV-2에 대한 BBIBP-CorV(Sinopharm) 및 BNT162b2(Pfizer-BioNTech) 백신에 의해 유도된 항체 및 T 세포 반응의 비교

Original Article

Published on 2021-10-112022-09-11
Journal: GeroScience [Category] MERS, SARS, 치료법,

[키워드] adaptive Adaptive immunity Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies Anti-spike antibody BBIBP-CorV BNT162b2 cell-mediated immune response Cell-mediated immune responses Convalescent patients cumulative domain effective elicit elicited epitope Epitopes evaluate healthy healthy individuals Human humoral IFNγ ELISpot assay IFNγ-producing T cells IFNγ IgA antibodies IgA antibody IgG immune response immune responses Immunity immunologically in healthy individuals inactivated injected investigated Live virus membrane mRNA mRNA vaccine mRNA-based much lower nucleocapsid participant pattern Pfizer-BioNTech Protein Proteins Quantitative RBD S protein epitopes SARS-CoV-2 SARS-CoV-2 virus Sinopharm supplementary material T cell T cell response target the S protein These data vaccination Vaccine virus Volunteer
[DOI] 10.1007/s11357-021-00471-6 PMC 바로가기 [Article Type] Original Article

Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients

전사체 분석, 코로나19 환자 눈물 각질화에 관여하는 유전자 발현 증가

Article

Published on 2021-10-062022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] affected Analysis B cell B cell response Cell signaling Chain Reaction conjunctivitis coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Diagnostic markers downregulated evidenced functional Gene Expression Gene regulation healthy individual healthy individuals healthy subject healthy subjects increased expression indicated induce involved keratinization mRNA expression next generation sequencing NGS ocular Patient patients with COVID-19 polymerase chain polymerase chain reaction Predictive markers Prognostic markers Real time reverse transcription polymerase chain reaction recent reverse transcription SARS-CoV-2 several gene several genes Signaling statistically Symptom tears time Transcriptome upregulated viral infection
[DOI] 10.1038/s41598-021-99344-3 PMC 바로가기 [Article Type] Article

Blood Transcriptomes of Anti-SARS-CoV-2 Antibody-Positive Healthy Individuals Who Experienced Asymptomatic Versus Clinical Infection

Immunology

Published on 2021-10-052022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] ALOX15 analysed Anti-SARS-CoV2 antibody Antibody Response asympomatic Asymptomatic Asymptomatic disease asymptomatic infection baseline baseline expression Bioinformatics analysis CACNA2D2 CLEC12A CLEC1B clinical clinical variability Course decreased expression develop differentially expressed gene ENC1 energy metabolism FOLR3 GCAT gene signature GZMH healthy individuals Hypothesis IFI44L IFIT3 immune immune response implication increased expression individual Infection innate immune response Innate immunity interferons involved lethal disease mRNA translation nine oxidative stress response PCR performed PI3 predicts protein-coding gene Proteins regulated RNA sequencing RNAseq robust RSAD2 SARS-CoV-2 SARS-COV-2 infection significantly transcriptional vaccination Whole-blood
[DOI] 10.3389/fimmu.2021.746203 PMC 바로가기 [Article Type] Immunology

Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression

면역 억제를 받는 환자에서 SARS-CoV-2 백신 접종에 대한 체액 및 T 세포 반응

Article

Published on 2021-10-012022-09-11
Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 진단, 치료기술,

[키워드] antibody Antibody Response assays Autoimmune Autoimmune diseases B-cell B-lymphocytes BNT162b2 BNT162b2 mRNA ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccines Combination COVID-19 detectable Diseases Efficacy Evidence evidence of failure glomerular glomerular diseases healthy individuals immune responses immunogenic immunogenicity Immunological response Immunosuppression immunosuppressive immunosuppressive therapies immunosuppressive therapy impair induce investigated Lymphocytes mounted non-responder participant Patient preserved receiving responders response responses rituximab robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion seroconvert seroconverted serological serology T-cell ELISpot T-cell Response T-cell responses tacrolimus therapy vaccination Vaccine vaccine dose Vaccines were used
[DOI] 10.1136/annrheumdis-2021-220626 PMC 바로가기 [Article Type] Article

SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity

리툭시맙 치료 환자에서 SARS-CoV-2 백신 접종: T 세포 매개 면역이 있는 경우 B 세포가 체액성 면역 반응을 촉진합니다

Article

Published on 2021-10-012022-09-11
Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 진단, 치료기술,

[키워드] Affect antibody assays B cell B cells BNT162b2 CD19 controls correlated COVID-19 detectable develop Elecsy enzyme enzyme-linked immunosorbent except for healthy control healthy individual healthy individuals humoral humoral immune response humoral immune responses IFN-γ immune response immune responses immunisation immunoassay independent independent of induce levels of antibody mounted mRNA mRNA-1273 n=36 neutralisation neutralisation tests Neutralising Antibodies neutralising antibody one patient Patient patients peripheral B cell peripheral B cells promote protective effect Protective effects quantified RBD Receptor-binding domain responses rituximab RTX SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccination SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells SARS-CoV-2-specific T-cell response SARS-CoV-2-specific T-cell responses seroconverted significantly specific antibodies Spike protein T cells T-cell responses T-cell-mediated immunity the patient the receptor-binding domain the SARS-CoV-2 the spike protein therapy Treatment vaccination
[DOI] 10.1136/annrheumdis-2021-220781 PMC 바로가기 [Article Type] Article

Hidden danger of COVID-19 outbreak: evaluation of subclinical myocardial dysfunction in patients with mild symptoms

COVID-19 발병의 숨겨진 위험 : 경증 환자의 무증상 심근 기능 장애 평가

Article

Published on 2021-10-012022-09-11
Journal: The International Journal of Cardiovascular Imagin [Category] SARS, 치료기술,

[키워드] age analyzed Apical Appetite asthenia C-reactive protein C-reactive protein (CRP cardiac complication Cardiac complications cardiac status caused collected Control controls cough COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cross-sectional Doppler evaluate female Fever functions Global longitudinal strain global public health group healthy controls healthy individuals healthy volunteer hospitalized patients Infection information left left ventricle loss of appetite LV systolic dysfunction male Mild symptom Mortality myalgia Myocardial dysfunction no significant difference Novel coronavirus novel coronavirus SARS-CoV-2 parameter Patient Plasma level Plasma levels presenting symptom prevalent secondary to significantly significantly higher significantly lower single-center study Speckle tracking echocardiography Subclinical Subclinical myocardial dysfunction. symptomatic the healthy ventricular
[DOI] 10.1007/s10554-021-02318-9 PMC 바로가기 [Article Type] Article

Double Negative (DN) B cells: A connecting bridge between rheumatic diseases and COVID-19?

Review

Published on 2021-09-302022-10-31
Journal: Mediterranean Journal of Rheumatology [Category] COVID-19,

[키워드] accumulate acute respiratory syndrome Autoimmune B cell cause caused CD27 Cell coronavirus COVID-19 COVID-19 patients Critical death described disease severity Diseases DN2 Double negative B cells Evidence expand expression group healthy individuals higher risk highlight immune response Immunoglobulin immunological immunopathology immunosuppressive therapies Infection Infectious disease Inflammation investigated laboratory parameter lack Lupus management marker memory morbidity and mortality negative outcome pandemic Patient patients recent rheumatic disease Rheumatic diseases rheumatological patient SARS-CoV-2 severe cases severe pneumonia subset Wuhan, China
[DOI] 10.31138/mjr.32.3.192 PMC 바로가기 [Article Type] Review