healthy subjects – Page 8 – Communicable Diseases Research

Structural and metabolic brain abnormalities in COVID-19 patients with sudden loss of smell

갑작스런 후각 소실을 동반한 코로나19 환자의 구조적 및 대사적 뇌 이상

Article

Published on 2021-06-012022-09-11
Journal: European Journal of Nuclear Medicine and Molecular [Category] Coronavirus, SARS, 치료기술,

Proteomics of extracellular vesicles in plasma reveals the characteristics and residual traces of COVID-19 patients without underlying diseases after 3 months of recovery

혈장 내 세포외 소포체 단백질체학, 3개월 회복 후 기저질환 없는 코로나19 환자의 특성 및 잔류 흔적 밝혀

Article

Published on 2021-05-252022-09-11
Journal: Cell Death & Disease [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술,

[키워드] addition Alanine alanine aminotransferase alkaline phosphatase ALP ALT association bleeding cellular change characteristic Characteristics Clinical characteristics Coagulation controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Ct value defined differentially expressed discharge dysfunction EVs extracellular vesicle Extracellular vesicles functions healthy subject healthy subjects Identified immune response Immunity Increasing Inflammation inflammatory reaction Intervention involved kidney mass mass spectrometry metabolic process molecular organ organ dysfunction organ function oxygen Patient phosphatase plasma Prevent Protein proteome proteomics recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Reinfection reported reveal serum electrolyte significantly lower situation Spectrometry Stress suffered underlying disease underlying diseases unique was used
[DOI] 10.1038/s41419-021-03816-3 PMC 바로가기 [Article Type] Article

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

건강한 지원자와 COVID-19 환자에 대한 메플라주맙의 안전성 및 효능: 무작위 1상 및 탐색적 2상 시험

Clinical Trial

Published on 2021-05-172022-08-13
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료제,

[키워드] abstracts accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-CD147 antibody assigned biodistribution study blocking C max cardiac blood–pool ratio CD147 Cohort cohorts conducted control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia determine discharged dosage double-blinded Efficacy eight enrolled evaluate Evidence exploratory phase 2 exploratory phase 2 study healthy subjects healthy volunteer healthy volunteers hospitalized patient humanized IgG in vitro incidence indicated Infection involved lung lung tissue Meplazumab meplazumab treatment monoclonal antibody Patient patients Peripheral blood pharmacokinetic characteristics pharmacokinetics Phase 1 phase 1 study phase 1 trial Phase 2 Placebo placebo-controlled Pneumonia positive Prevent Randomized reached recent receptor reduced respiratory Safety safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serum severe acute respiratory syndrome Coronavirus severity significantly subject suppress TEAE titer Tolerability Tolerance treatment-emergent adverse event Trial virus
[DOI] 10.1038/s41392-021-00603-6 PMC 바로가기 [Article Type] Clinical Trial

Salivary Biomarkers in COVID-19 Patients: Towards a Wide-Scale Test for Monitoring Disease Activity

Article

Published on 2021-05-082022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

Increased Serum Levels of Soluble TNF-α Receptor Is Associated With ICU Mortality in COVID-19 Patients

가용성 TNF-α 수용체의 증가된 혈청 수준은 COVID-19 환자의 ICU 사망률과 관련이 있습니다

Immunology

Published on 2021-04-222022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Admission age ARDS Biomarker cause Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease cytokine Cytokine storm death determinant determinants disease disease severity ELISA ESR Future greater healthy control healthy subjects ICU ICU patient ICU Patients Increased intensive care intensive care unit Iran laboratory-confirmed Laboratory-confirmed COVID-19 Level Mild Mortality non-ICU non-ICU patient non-ICU patients objective Older outcome Patient positively correlated receptor recruited respiratory respiratory distress Respiratory distress syndrome Result SARS-CoV-2 serum Serum level serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe disease significantly higher soluble TNF-α subject syndrome Tehran the healthy TNF-α TNF-α Ventilation
[DOI] 10.3389/fimmu.2021.592727 PMC 바로가기 [Article Type] Immunology

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

IFN-γ 및 TNF-α는 심각한 COVID-19 폐 및 조직 염증이 있는 염증성 질환에서 확장된 CXCL10+ CCL2+ 대식세포 표현형을 유도합니다

Research

Published on 2021-04-202022-08-13
Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] affected anti-cytokine antiviral interferon approach Arthritis association bronchoalveolar lavage samples CCL2 CCL3 CD ileum Cell cell-type identification cellular phenotype cellular phenotypes Combination COVID-19 Crohn’s disease CXCL10 CXCL9 Cytokines defined disease-affected donor disease-affected donors disparate Donor driving Effect elevated environmental factor environmental factors established therapy exhibited FIVE GBP1 Genes healthy healthy control healthy subject healthy subjects help human blood-derived macrophage human blood-derived macrophages identify IFN-beta IFN-beta (IFN-β IFN-gamma IFN-β IFN-γ IL1B Immune cell immune cell state immune cell states immune state Immunomodulatory therapies inflamed CD ileum inflamed RA synovium inflamed tissue inflamed tissues Inflammatory inflammatory disease Inflammatory diseases inflammatory factors inflammatory macrophage phenotype Integrative analysis interferon response interferons Interstitial lung disease lung Lung disease lupus erythematosus Macrophage Macrophage heterogeneity macrophage phenotype macrophage phenotypes macrophage state Macrophage stimulation macrophages Meta-analysis mixed-effects modeling Patient patients with COVID-19 pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines protective effect RA synovium Result rheumatoid arthritis severe COVID-19 severe COVID-19-affected lungs single-cell Single-cell multi-disease tissue integration single-cell profile Single-cell transcriptomics SLE Stat1 stimulated Stimulation Support systemic lupus erythematosus tested These cells tissue tissue inflammation tissues TNF TNF-α transcriptomic profile Treatment UC colon ulcerative colitis understanding
[DOI] 10.1186/s13073-021-00881-3 PMC 바로가기 [Article Type] Research

Seroprevalence of Antibodies against SARS-CoV-2 in Children with Juvenile Idiopathic Arthritis a Case-Control Study

Article

Published on 2021-04-192022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Serum cytokine levels of COVID-19 patients after 7 days of treatment with Favipiravir or Kaletra

Favipiravir 또는 Kaletra로 치료 7일 후 COVID-19 환자의 혈청 사이토카인 수치

Observational Study

Published on 2021-04-012022-09-11
Journal: International immunopharmacology [Category] SARS, 임상, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission age Anti-viral therapy Antiviral antiviral therapy Antiviral treatment antiviral treatments baseline baseline level baseline levels Blood level blood levels C-reactive protein C-reactive protein (CRP cause change Chest computed tomography Computed tomography coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP CT scan cytokine cytokine level Cytokine storm Cytokines Cytokines storm death elevated evaluated Evidence Favipiravir Flow flow cytometry healthy control healthy controls healthy subject healthy subjects IFNγ IL-1β IL-6 IL-8 inflammatory phase intensive care intensive care unit interferon interleukin interleukin-6 Kaletra laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Lopinavir Lopinavir/ritonavir lung Lung inflammation manifestation Necrosis observational study occurred Patient reduced retrospective Ritonavir SARS-CoV-2 serum serum cytokine serum cytokines Serum level serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe COVID-19 patients significantly subject subjects Supportive treatment suppress therapy TNFα Treatment Tumor tumor necrosis tumor necrosis factor was obtained
[DOI] 10.1016/j.intimp.2021.107407 PMC 바로가기 [Article Type] Observational Study

The Impact of COVID-19-Related Lockdown on Diet and Serum Markers in Healthy Adults

건강한 성인의 식단 및 혈청 지표에 대한 COVID-19 관련 잠금의 영향

Article

Published on 2021-03-262022-09-10
Journal: Nutrients [Category] 바이오마커,

[키워드] Adults Asymptomatic baseline Blood Blood samples BMI body composition changes in cholesterol Contact correlated diet dietary habits eating energy Energy intake Fatty acid fatty acids Glucose groups Health Health status healthy healthy subject healthy subjects Impact increase increase in Increased index LDL less limit limits lockdown low-density Low-density lipoprotein lower physical activity levels marker nutrition omega-6 fatty acids participated physical activity physical activity level preliminary report quarantine questionnaire Questionnaires reduced returned serum serum biomarkers Serum Marker serum markers significant changes in significant increase subject Total cholesterol
[DOI] 10.3390/nu13041082 PMC 바로가기 [Article Type] Article

Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ

Article

Published on 2021-03-202022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,