Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccinesSARS-CoV-2 스파이크 단백질 중화 항체 탈출: 항체 기반 Covid-19 치료제 및 백신에 대한 위험 평가Review Published on 2021-11-012022-09-11 Journal: Reviews in Medical Virology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Affect African antibody B.1.1.7 B.1.351 bamlanivimab BNT162b2 Casirivimab circulating clades Combination convalescent convalescent plasma convergent evolution COVID-19 Deletion E484K Efficacy etesevimab focus hotspot Imdevimab immune Immune escape immunoglobulins inventory L452R LY-CoV555 LyCoV016 monoclonal antibodies mRNA mRNA-1273 Mutation mutations N439K N501Y neutralising neutralising antibody P.1 P.2 Phylogenetic polyclonal polyclonal immunoglobulins. Protein RBD Receptor binding domain REGN10933 REGN10987 Risk assessment S477N SARS-CoV-2 SARS-CoV-2 spike serum South spike Spike protein Strains target Therapeutics Vaccine Vaccines variants of concern Y453F [DOI] 10.1002/rmv.2231 PMC 바로가기 [Article Type] Review
Understanding mutation hotspots for the SARS-CoV-2 spike protein using Shannon Entropy and K-means clusteringShannon Entropy 및 K-means 클러스터링을 사용한 SARS-CoV-2 스파이크 단백질의 돌연변이 핫스팟 이해Article Published on 2021-11-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] Analysis carried Characteristics Cluster Clustering Community complex contagious determine Entropy helping hotspot identify in some indels K-means clustering laboratory investigation mutant mutants Mutation mutational hotspot mutations nine predicted Region regions required Research SARS-CoV-2 SARS-CoV-2 virus sequence Shannon entropy similarities similarity situation Spike protein statistical Substitution substitutions survival susceptible the SARS-CoV-2 the spike protein Therapeutics time-consuming understanding variant variants variants of concern variants of interest virus zone [DOI] 10.1016/j.compbiomed.2021.104915 PMC 바로가기 [Article Type] Article
Spatial variation and hotspot detection of COVID-19 cases in Kazakhstan, 20202020년 카자흐스탄의 COVID-19 사례의 공간적 변이 및 핫스팟 감지Article Published on 2021-11-012022-09-11 Journal: Spatial and spatio-temporal epidemiology [Category] Coronavirus, SARS, 치료기술, 치료제, [키워드] Almaty Analysis city Cluster Cluster detection Clustering continuity COVID-19 COVID-19 case COVID-19 cases COVID-19 epidemic defined detect distribution Epidemic feature hotspot Infectious disease information Kazakhstan life-threatening measure QGIS risk Spatial analysis Spread Variation virus zoonotic origin [DOI] 10.1016/j.sste.2021.100430 PMC 바로가기 [Article Type] Article
Fear of Infection and the Common Good: COVID-19 and the First Italian LockdownArticle Published on 2021-10-282022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] Analysis asked collective behavior common conditions conducted COVID-19 COVID-19 infection fear fear of infection Government Health hotspot indicate Infection Italian Italy lockdown partial least square Pathogens Psychological Safety measures self-control significantly social dilemma Vaccine [DOI] 10.3390/ijerph182111341 PMC 바로가기 [Article Type] Article
Extent of compliance with COVID-19 prevention and control guidelines among supermarkets in Kampala Capital City and Mukono Municipality, UgandaResearch Article Published on 2021-10-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Capital city collected Compliance conducted COVID-19 COVID-19 transmission cross-sectional Descriptive statistics Evidence Face mask face masking Follow-up Health authority hotspot hygiene Infection prevention Interaction involved mandatory measure Measures Ministry of Health Mortality municipality observation preventive measure provided Public Randomly required Result selected social distancing Spread supermarket tablets temperature Uganda with COVID-19 [DOI] 10.1371/journal.pone.0258840 PMC 바로가기 [Article Type] Research Article
Genomic epidemiology reveals multiple introductions of SARS-CoV-2 followed by community and nosocomial spread, Germany, February to May 2020게놈 역학은 2020년 2월부터 5월까지 독일에서 SARS-CoV-2의 다중 도입에 이어 지역사회 및 병원 내 확산을 보여줍니다.Research Published on 2021-10-282022-09-10 Journal: Eurosurveillance [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis applied ARTIC protocol Cluster Combination Community containment strategies COVID-19 case effective Epidemiology Europe full-length genome sequence genomic Genomic epidemiology Germany healthcare worker Healthcare workers high resolution Hospital-acquired infection hospital-acquired infections hotspot independent interactions International interpersonal interaction interpersonal interactions investigated Local Metadata Munich National nosocomial spread Nosocomial transmission outbreak outbreak control pandemic Patient phylogenetic analyses Region resolved respiratory Respiratory samples Result reveal SARS-CoV-2 SARS-CoV-2 pandemic sequence single person Spread superspreading event the SARS-CoV-2 timeline timelines Transmission Travel university hospital Viral viral genome viral genomes viral spread virus [DOI] 10.2807/1560-7917.ES.2021.26.43.2002066 PMC 바로가기 [Article Type] Research
Distant residues modulate conformational opening in SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 구조적 개방을 조절하는 먼 잔류물408 Published on 2021-10-262022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, [키워드] A570D ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all-atom molecular dynamics simulations Analysis antibody applied attachment binding conformational conformational change conserved contagious coronavirus correlation correlations COVID-19 D614G mutation Data analysis Distant drug drug design drug resistance effort Epidemics event focus Health crisis host cells hotspot identify implication independent independent component analysis Infection initiated involved membrane modulate molecular molecular biophysics molecular dynamics Molecular dynamics simulation monoclonal antibodies monoclonal antibody multiple coronaviruses mutant Mutation mutations new strain Novel coronavirus Outbreaks pandemic predicted Protein public health crisis RBD RBD region receptor Receptor-binding domain Region residue residues respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Significance Significant Spike protein Spike proteins statistical mechanics the RBD the receptor-binding domain the spike protein therapeutic Therapeutics Transmissibility treat Vaccine virulence virus structure [DOI] 10.1073/pnas.2100943118 PMC 바로가기 [Article Type] 408
Wastewater surveillance-based city zonation for effective COVID-19 pandemic preparedness powered by early warning: A perspectives of temporal variations in SARS-CoV-2-RNA in Ahmedabad, India조기 경보를 통한 효과적인 COVID-19 전염병 대비를 위한 폐수 감시 기반 도시 구역 지정: 인도 아마다바드에서 SARS-CoV-2-RNA의 시간적 변화에 대한 관점Article Published on 2021-10-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] analyzed average Community Concentration confirmed cases coronavirus 2 COVID-19 COVID-19 pandemic descending detect effective Epidemiology followed by Gujarat heat map hotspot India lead limitation ORF pandemic Perspective predicted prediction respiratory RNA SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes SARS-CoV-2 RNA severe acute respiratory coronavirus severe acute respiratory coronavirus 2 shown Surveillance surveillance data utility Variation wastewater Wastewater based epidemiology (WBE) [DOI] 10.1016/j.scitotenv.2021.148367 PMC 바로가기 [Article Type] Article
Severity, Pathogenicity and Transmissibility of Delta and Lambda Variants of SARS-CoV-2, Toxicity of Spike Protein and Possibilities for Future Prevention of COVID-19Review Published on 2021-10-182022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 ACE2 receptor amino acid substitution antibody changes in claimed COVID-19 Delta delta variant Effective vaccines Epitopes furin furin protease Future future therapeutic high stability hotspot immune response Lambda Lambda variant less Mutation N protein NAbs neutralizing antibody NTD pathogenicity prevention Protein receptor S protein S proteins SARS-CoV-2 SARS-CoV2 severity spike spike protein toxicity the N protein the S protein Toxicity Treatment TRIM21 vaccinated individuals Vaccine development variant variants virus infection while World Health Organization Wuhan strain [DOI] 10.3390/microorganisms9102167 PMC 바로가기 [Article Type] Review
Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and TransmissionMicrobiology Published on 2021-10-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome ADAR analyzed APOBEC association Asymptomatic Beta clinical Clinical outcome Complete coronavirus coronavirus 2 coronavirus disease correlated COVID-19 Critical D614G enzyme Epidemic expression Frame Frequency Gamma GISAID database hotspot mechanism Mild mild case Mutation mutation hotspots mutations occur occurred ORF1ab outcome pandemic predict Prevalence Q57H RdRP respiratory RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 sequence severe cases severe disease shown single-nucleotide SNV strain Strains symptomatic the SARS-CoV-2 the SARS-CoV-2 genome Treatment understanding variant [DOI] 10.3389/fmicb.2021.753823 PMC 바로가기 [Article Type] Microbiology