human ACE2 – Page 8 – Communicable Diseases Research

Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2 -transgenic mice

비활성화된 SARS-CoV-2는 인간 ACE2 형질전환 마우스에서 급성 호흡곤란 증후군을 유발합니다

Article

Published on 2021-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료제,

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice

소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다

Pathogenesis and Immunity

Published on 2021-12-222022-09-10
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus viruses
[DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

베타가 아닌 알파의 SARS-CoV-2 변종에 대한 향상된 적합성

Comparative Study

Published on 2021-12-222022-09-10
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 airway Alpha Alpha variant angiotensin assessment B.1.1.7 B.1.351 Beta Beta variant COVID-19 pandemic cultures driver driving enhanced epithelial experiment Experimental models of disease expressing ferret ferrets fitness greater hamster hamsters high viral replication highlight human ACE2 human Angiotensin-converting enzyme in vitro in vivo mechanism mice nasal overcome progenitor receptor Replication respiratory SARS-CoV-2 SARS-CoV-2 variant similar replication kinetics Spike protein Substitution substitutions Support the spike protein Transmission upper respiratory tract variant variants of concern Viral viral infection virus VoC VOCs
[DOI] 10.1038/s41586-021-04342-0 PMC 바로가기 [Article Type] Comparative Study

Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2

Short Reports

Published on 2021-12-212022-10-28
Journal: PLoS Biology [Category] COVID-19, SARS,

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Research Article

Published on 2021-12-202022-10-31
Journal: eLife [Category] COVID-19, SARS,

Biparatopic nanobodies protect mice from lethal challenge with SARS‐CoV‐2 variants of concern

2중 파라토프 나노바디는 우려되는 SARS-CoV-2 변종으로 인한 치명적인 공격으로부터 마우스를 보호합니다

Article

Published on 2021-12-202022-09-10
Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] (Beta active against Analysis B.1 B.1.351 B.1.617.2 Beta cellular circulating circulating variant conserved COVID‐19 Delta Disease progression dose drug candidates effective epitope epitope mapping Epitopes generate high affinity human ACE‐2 mouse human ACE2 immunology in vitro in vivo increased survival Infection Inflammatory response intranasally lethal dose Lungs mice Microbiology, Virology & Host Pathogen Interaction Molecular Biology of Disease nanobodies nanobody neutralize Neutralizing neutralizing nanobodies pandemic Prevent PROTECT RBD receptor‐binding domain reduced SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 significantly Taking Therapeutics These data transgenic mice treat treated variants of concern variety Viral Viral load VoC VOCs
[DOI] 10.15252/embr.202153865 PMC 바로가기 [Article Type] Article

SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation

423

Published on 2021-12-202022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antiviral target arginine Beta binding caused cell line cellular cleavage cleavage site complement coronavirus coronavirus strains COVID-19 pandemic delta variant functional consequence highlight Host host cell host receptor human ACE2 Infection inhibiting initial mechanism membrane fusion mice molecular molecular mechanism Outbreaks pandemic Prevent primary cell Protein proteolytic proteolytic activation Proteolytic processing Receptor binding Research residue responsible S2 subunit S2′ S2′ cleavage S2′ site SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike variants Significance Spike protein subsequent syncytia formation target cells understanding variety viral entry viral infection viral spike
[DOI] 10.1073/pnas.2111199119 PMC 바로가기 [Article Type] 423

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

SARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.

Article

Published on 2021-12-012022-09-11
Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘,

[키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased
[DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Article

Published on 2021-11-252022-10-04
Journal: Nature Communications [Category] Fulltext, MERS, SARS, 변종, 조류인플루엔자,

In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environment

Article

Published on 2021-11-242022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,