IL-2 – Page 8 – Communicable Diseases Research

Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate

Research Article

Published on 2021-11-232022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People

고령자에서 BNT162b2 mRNA 백신 2회 접종 후 SARS-CoV-2에 대한 기능적 T-세포 반응 손상

Comparative Study

Published on 2021-11-162022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome addition Adults Affect alteration analyzed antibody Antibody Response antibody response against Antibody titer baseline BNT162b2 vaccine CD4 CD8 Cell cellular collected coronavirus COVID-19 infection dose Efficiency ELISPOT flow cytometry Frequency functional greater high plasma level Humoral immunity IFNγ IgG IL-2 immune response Immunity Immunocompromised Impaired injection Long-term care median age memory response mRNA mRNA vaccination mRNA-based vaccines neutralizing antibody neutralizing antibody titers of BNT162b2 Older older people and ageing parameter participant Participants physiological postvaccination quantified response SARS – CoV – 2 SARS-CoV-2 Specific T-cell response subjects suggested T cell T cells T cells response T-cell T-cell responses TNFα vaccination Vaccine vaccine responses
[DOI] 10.3389/fimmu.2021.778679 PMC 바로가기 [Article Type] Comparative Study

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Article

Published on 2021-11-112022-10-31
Journal: Cell [Category] COVID-19, MERS, SARS,

[키워드] Abstract accelerate accelerated accompanied acute respiratory syndrome addressed administration Alpha amplified antibody antibody level B cell B.1.1.7 BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine CD4 cellular circulating contribute coronavirus Coverage COVID-19 COVID-19 vaccine dose dosing interval effective expressing extended interval extension healthcare Humoral response IL-2 immunogenic immunogenicity individuals induce Infection introduced mRNA vaccine neutralization neutralizing antibody of BNT162b2 Protective protocol regimen response responses SARS-CoV-2 SARS-COV-2 infection second dose single dose sustained T cell the spike protein Trial United Kingdom Vaccine vaccine dose variant variants of concern
[DOI] 10.1016/j.cell.2021.10.011 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS

Immunology

Published on 2021-11-102022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study

Articles

Published on 2021-11-092022-10-29
Journal: The Lancet Rheumatology [Category] COVID-19,

[키워드] 95% CI Administered All participant Alpha Antibody Response B.1.1.7 B.1.617.2 BNT162b2 Cell cellular cellular immunity cellular response Cohort cohort study college Control COVID-19 vaccine defined Delta variants demonstrated detectable eight England evaluated extended interval finding foundation functional funding General population group healthy control healthy controls Humoral immunity IL-17 IL-2 IL-21 IL-23 immune response Immune-mediated inflammatory disease immunogenicity Immunosuppressant Immunosuppression individual inhibitor inhibitors interferon-γ IQR King London longitudinal cohort study magnitude male median median age methotrexate monotherapy Necrosis neutralising antibody Neutralising antibody responses neutralising antibody titre NHS NIHR no difference of BNT162b2 participant Patient Pfizer-BioNTech Primary outcome producing proportion psoriasis receiving recruited regimen robust SARS-CoV-2 variants second dose second vaccination single dose spike glycoprotein Spike-specific antibody spike-specific IgG spike-specific T-cell response study population T-cell Response the SARS-CoV-2 Thoma titre TNF Trust vaccination vaccine dose vaccine doses Volunteer white wild-type
[DOI] 10.1016/S2665-9913(21)00333-7 PMC 바로가기 [Article Type] Articles

Phillyrin for COVID-19 and Influenza Co-infection: A Potential Therapeutic Strategy Targeting Host Based on Bioinformatics Analysis

Pharmacology

Published on 2021-11-042022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Persistent intrathecal interleukin-8 production in a patient with SARS-CoV-2-related encephalopathy presenting aphasia: a case report.

Case Report

Published on 2021-11-022022-10-27
Journal: BMC Neurology [Category] COVID-19,

[키워드] Aphasia Brain Case report Central nervous system cerebrospinal fluid characteristic Clinical course coronavirus disease Corticosteroid COVID-19 CSF cytokine profile demonstrated Dexamethasone direct infection Encephalopathy IL-10 IL-2 IL-6 IL-8 Immunotherapy include increasingly Inflammation Intravenous immunoglobulin manifestation MCP-1 Methylprednisolone monitoring monocyte chemoattractant protein-1 much higher Neurological deficit occur Patient persistent presenting pulse remained Remdesivir required SARS-CoV-2 SARS-COV-2 infection Seizure serum supplementary material systemic inflammation Treatment
[DOI] 10.1186/s12883-021-02459-3 PMC 바로가기 [Article Type] Case Report

Persistent intrathecal interleukin-8 production in a patient with SARS-CoV-2-related encephalopathy presenting aphasia: a case report.

Case Report

Published on 2021-11-022022-10-27
Journal: BMC Neurology [Category] Coronavirus, COVID-19, MERS, SARS,

[키워드] Aphasia Brain Case report Central nervous system cerebrospinal fluid characteristic Clinical course coronavirus disease Corticosteroid COVID-19 CSF cytokine profile demonstrated Dexamethasone direct infection Encephalopathy IL-10 IL-2 IL-6 IL-8 Immunotherapy include increasingly Inflammation Intravenous immunoglobulin manifestation MCP-1 Methylprednisolone monitoring monocyte chemoattractant protein-1 much higher Neurological deficit occur Patient persistent presenting pulse remained Remdesivir required SARS-CoV-2 SARS-COV-2 infection Seizure serum supplementary material systemic inflammation Treatment
[DOI] 10.1186/s12883-021-02459-3 PMC 바로가기 [Article Type] Case Report

Sample Processing and Stability for Urine Biomarker Studies

소변 바이오마커 연구를 위한 시료 처리 및 안정성

Article

Published on 2021-11-012022-09-11
Journal: The journal of applied laboratory medicine [Category] MERS, SARS, 바이오마커,

[키워드] 48 hour 48 hours acute kidney Acute kidney injury Alpha Biomarker Biomarkers biospecimen handling biospecimen storage centrifugation chitinase collected Concentration condition conditions COVID-19 COVID-19 pandemic current demonstrated determine Device Effect EGF epidermal epidermal growth factor Foley catheter freezing growth factor handling hospitalized patient IL-12p70 IL-13 IL-18 IL-1β IL-2 IL-4 IL-6 IL-8 interferon gamma interleukin investigated Kidney injury MCP-1 measurement monocyte monocyte chemoattractant protein-1 Necrosis neutrophil New notable osteopontin processing Protein protein stability reference standard remained Research robust Sample significant difference significant differences spot tested TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha UMOD Urinalysis urinalysis. Urine Variation variations were used YKL-40
[DOI] 10.1093/jalm/jfab082 PMC 바로가기 [Article Type] Article

Prevention of Cyclophosphamide-Induced Immunosuppression in Mice With Traditional Chinese Medicine Xuanfei Baidu Decoction

Pharmacology

Published on 2021-10-192022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] administration applied Baidu Body weight loss calculated CD4 CD8 cell proliferation China Chinese COVID-19 disease Cyclophosphamide cytokine Decoction ELISA evaluate evaluated groups IFN-γ IgG IgM IL-2 IL-4 IL-6 expression immune immune modification Immunoglobulin Immunosuppression liver LPS lymphocyte mechanism Medicine mice Modification organ prevention proliferation protective effect reduction RT-PCR serum significantly spleen Splenic staining Structure suggested suppressed T lymphocyte therapy TNF-α Traditional Traditional Chinese medicine Treatment was measured was performed Xuanfei Baidu Decoction
[DOI] 10.3389/fphar.2021.730567 PMC 바로가기 [Article Type] Pharmacology