Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19Cell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus [DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology
Impaired Myocardial Function Is Prognostic for Severe Respiratory Failure in the Course of COVID-19 InfectionCardiovascular Medicine Published on 2021-06-042022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory distress all-cause mortality approach ARDS Blood cardiovascular comorbidities cardiovascular disease consecutive patient COVID-19 COVID-19 patient distress elevated failure First wave function Germany heart Hospital admission Impaired impaired cardiac function IMPROVE marker mechanical ventilation morbidity and mortality Mortality Myocardial Myocardial function NT-pro-BNP outcome pandemic Patient performed Physicians Prognosis respiratory resulting SARS-COV-2 infection subsequent syndrome thrombotic treated Treatment tricuspid Tübingen university [DOI] 10.3389/fcvm.2021.584108 PMC 바로가기 [Article Type] Cardiovascular Medicine
Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease SeverityICU에 입원한 COVID-19 환자의 PBMC에서 손상된 세포독성 반응: 질병 중증도를 예측하는 바이오마커Immunology Published on 2021-05-262022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Admission advance Algorithm analyzed association Biomarkers blood sample Blood samples cause CD4 CD8 lymphocytes + CD8+ T cell CD8+ T cells Cell cell population Cellular immune response center COVID-19 COVID-19 severity Critical cytotoxic cytotoxic cell cytotoxic response decrease develop effort elicit feature forest form hospitalized patients ICU IL-2 immune immune response immunological parameter Impaired infected cell infected cells Inflammatory response Invasive mechanical ventilation marker MHC class I MHC class I molecules NK and NKT cells NKT Novel coronavirus novel coronavirus SARS-CoV-2 pandemic parameter Patient PBMC plasma predict pseudotyped SARS-CoV-2 Random forest recruited reduce viral replication reduced response SARS-CoV-2 SARS-COV-2 infection Spain subpopulation susceptible T cell T cells target cell target cells Th1 the disease to define translated Tregs Viral viral replication [DOI] 10.3389/fimmu.2021.665329 PMC 바로가기 [Article Type] Immunology
Impaired Glucose-Insulin Metabolism in Multisystem Inflammatory Syndrome Related to SARS-CoV-2 in ChildrenCommunication Published on 2021-05-132022-10-31 Journal: Children [Category] COVID-19, [키워드] affected assessments average biochemical calculated children clinical coronavirus disease described evaluated fluctuation Glucose glycemic homeostasis Impaired impairment Inflammatory insulin insulin resistance Interaction marker MIS-C Multisystem inflammatory syndrome outcome Patient patients Pediatric patients Prevent Regular reported SARS-CoV-2 SARS-COV-2 infection syndrome threshold undergo were recorded [DOI] 10.3390/children8050384 PMC 바로가기 [Article Type] Communication
Type 1 Diabetes Mellitus in the SARS-CoV-2 Pandemic: Oxidative Stress as a Major Pathophysiological Mechanism Linked to Adverse Clinical OutcomesReview Published on 2021-05-092022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] “cytokine storm” ACE2 Activation acute respiratory syndrome adaptive Adverse Alpha association binding characterized chronic inflammation clinical clinical study cohorts Combination contribute coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis cytokine demonstrated determine diabete Diabetes Mellitus Diabetic disease severity elevated endothelial Endothelial cell Endothelial dysfunction enzyme extreme Glucose hyperglycemia IL-1β IL-2 IL-6 Immunity Impaired impairment Infection Inflammation life-threatening COVID-19 disease Major morbidity and mortality multi-organ failure Necrosis outcome outcomes oxidative stress pancreatic Pathogenesis pathway Patient PKC pro-inflammatory cytokines Protein recent receptor required risk factor SARS-CoV-2 the SARS-CoV-2 TNF-α turn Type Type 1 diabetes mellitus vaccination [DOI] 10.3390/antiox10050752 PMC 바로가기 [Article Type] Review
Impaired performance of SARS-CoV-2 antigen-detecting rapid diagnostic tests at elevated and low temperatures고온 및 저온에서 SARS-CoV-2 항원 검출 신속 진단 검사의 성능 저하Article Published on 2021-05-012022-09-10 Journal: Journal of Clinical Virology [Category] 진단, 치료기술, [키워드] Ag-RDT Ag-RDTs ambient ambient temperatures analytical sensitivity Antigen Antigen-detecting rapid diagnostic tests Cell culture cell culture supernatant clinically complement condition conditions consequence COVID-19 culture supernatant diagnostic tests diagnostics eight elevated elevated temperature Emergency use exhibited exposure to false-negative false-positive result False-positive results FIVE Genome Health Organization Highlights impair Impaired include Incubation limit limits Limits of detection low temperature Low temperatures mean temperature mean temperatures molecular molecular diagnostics North not affected occurred operation pandemic quarantine ranged rapid antigen test Rapid diagnostic test RDTs reduce reduced respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 cell sensitivity South specificity storage temperature Temperature stability test results tested the WHO Transmission Tropics virus concentration Virus concentrations viruses Winter World Health Organization [DOI] 10.1016/j.jcv.2021.104796 PMC 바로가기 [Article Type] Article
Impaired Humoral Response in Renal Transplant Recipients to SARS-CoV-2 Vaccination with BNT162b2 (Pfizer-BioNTech)Communication Published on 2021-04-252022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome anti-SARS-CoV-2 IgG antibody Antibody Response BNT162b2 CLIA Cohort Coronavirus-2 COVID-19 dose evaluated Germany HCW healthcare worker healthy control humoral immune response Impaired individual investigated Messenger RNA mortality rate mRNA-based mRNA-based vaccine Patient Pfizer-BioNTech positive protocol recipient recipients renal Renal transplant recipients Renal transplantation response SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose significantly lower solid organ transplant SOT tested the patient the SARS-CoV-2 Transplant vaccination Vaccination strategy Vaccine vulnerable patients was determined [DOI] 10.3390/v13050756 PMC 바로가기 [Article Type] Communication
Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severityResearch Article Published on 2021-04-162022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, [키워드] activating Activation adaptive antibody production approaches Bone marrow cause CD56 CD69 Cell circulating circulation Clinical deterioration Cohort conserved expression contribute Course COVID-19 COVID-19 patient cytokine production cytotoxicity death decrease Defense disease onset Disease progression disease severity disease trajectory downstream dysregulation early phase evidence of expression Extensive flow cytometry functional future therapeutic HLA-DR hospital IFN-γ immune Impaired impairment Inflammatory information inhibitory inhibitory receptor initial investigated KIR lack margination mechanism NK cell NK cell response NK cells NKG2A occur Patient patients patients hospitalized peripheral tissues precursor proportion receptor recruitment regulate Regulation responses SARS-COV-2 infection Strategy subsequent subset T cell responses the disease tissue Treatment turn Vaccine vascular leakage virus virus replication viruses [DOI] 10.1371/journal.ppat.1009448 PMC 바로가기 [Article Type] Research Article
Reduced Flow-Mediated Dilatation Is Not Related to COVID-19 Severity Three Months after Hospitalization for SARS-CoV-2 InfectionBrief Report Published on 2021-03-232022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute infection age appear brachial changes in Control control subjects coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical deaths determine Diagnosis dilatation flow-mediated dilatation follow-up study functional help Hospitalization hospitalized COVID-19 ICU Impaired indicate intensive care involved lung damage mechanism Month nine pandemic pathophysiology Prognosis reduced reflected SARS-CoV-2 SARS-COV-2 infection severity Sex Spread survivor Vascular Vascular endothelium Vascular function [DOI] 10.3390/jcm10061318 PMC 바로가기 [Article Type] Brief Report
Echocardiographic Characteristics and Outcome in Patients With COVID-19 Infection and Underlying Cardiovascular DiseaseCardiovascular Medicine Published on 2021-03-162022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory distress cardiac function cardiac injury cardiovascular cardiovascular disease coronavirus disease COVID-19 COVID-19 patient CVD demonstrated diastolic echocardiographic parameter echocardiography elevated enrolled event Heart injury hospitalized COVID-19 patient Impaired independent predictor Infection LV diastolic dysfunction LV systolic dysfunction manifestation mechanical ventilation Mortality non-intubated patients parameter Patient patients patients with COVID-19 Predictive Prognostic value RV dysfunction RV systolic function syndrome therapy thrombosis troponin I ventricular were assessed with COVID-19 worsening [DOI] 10.3389/fcvm.2021.642973 PMC 바로가기 [Article Type] Cardiovascular Medicine