Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines점막 바이러스 전염병 대처: COVID-19 백신의 교훈Review Published on 2022-04-012022-09-12 Journal: Mucosal Immunology [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] administration approaches booster dose cell-mediated response Combination contribute COVID-19 COVID-19 vaccine death demonstrated effective humoral IgA Immunity Infection infection with SARS-CoV-2 intramuscularly intranasal limitation Local lymphocyte response mucosal mucosal IgA response nasal mucosa New penetrate Preclinical Prevent primary site question reduce Safe SARS-CoV-2 severe disease Spread sustained tested Transmission Trial vaccination Vaccination strategy Vaccine viral strain [DOI] 10.1038/s41385-022-00517-8 PMC 바로가기 [Article Type] Review
Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2에피토프 기반 항원과 결합된 피하-비강내 면역화는 PRRSV-2 및 SARS-CoV-2에 대한 혈청 및 점막의 결합 및 중화 항체 반응을 유도합니다Article Published on 2022-03-312022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Administered Against animal antibodies antibody Antigen antigens Antiviral approaches asymptomatic infection baculovirus binding binding antibody Combination Combined Concentration conserved elicit emerging and re-emerging viruses envelope protein epitope epitope-based antigens evaluate evaluated expressed fluids generate GP5 Humoral response immunization immunization strategy immunized induce Infection inhibited inoculated Interaction intranasal intranasally investigated Local memory response mucosal mucosal antibodies Mucosal immunization nasal Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody New Prevent produced promoted Protein RBD-ACE2 receptor-binding motif recombinant baculovirus recombinant proteins recombinant proteins. reduce response responses SARS-CoV-2 serum serum antibody serum sample subcutaneously the S protein Transmission vaccinated individuals Vaccine design vaginal swabs virus [DOI] 10.3389/fimmu.2022.848054 PMC 바로가기 [Article Type] Article
From Deer-to-Deer: SARS-CoV-2 is efficiently transmitted and presents broad tissue tropism and replication sites in white-tailed deer사슴에서 사슴으로: SARS-CoV-2는 효율적으로 전염되며 흰꼬리사슴의 광범위한 조직 친화성과 복제 부위를 나타냅니다.Article Published on 2022-03-212022-09-11 Journal: PLoS Pathogens [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus added age Americas B.1 lineage causative agent Central nervous system Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deer demonstrated disease disease control effective host range humans hunting implementation infect Infection Infectious virus intranasal investigated lack lymphoid Measures nasal natural infection Odocoileus Prevent provide replication site reported reservoir SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown susceptible tissue tropism tissues Transmission Transmission dynamics transmitted tropism Viral load virus virus replication white-tailed deer wild animal zoonotic transmission [DOI] 10.1371/journal.ppat.1010197 PMC 바로가기 [Article Type] Article
Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22)비강 나노바디(Nb22)에 의해 부여된 hACE2 마우스의 SARS-CoV-2에 대한 단기 순간 예방 및 효율적인 치료Article Published on 2022-03-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] addition Administered Against alpaca binding blocked Breakthrough infection breakthrough infections caused circulating Community Complete COVID-19 vaccine current Delta delta variant demonstrated doses effective Efficacy efficient exhibited exhibiting hACE2 highlight immunized Inhaled inoculation instantaneous instantaneous prophylaxis instantaneous protection intranasal long-lasting nanobodies nanobody Nb22 neutralization PrEP Prophylaxis RBD reported respiratory Respiratory system SARS-CoV-2 Seven single dose Spike protein stability STIP Structural analysis Structure the spike protein therapeutic unmet need variants [DOI] 10.3389/fimmu.2022.865401 PMC 바로가기 [Article Type] Article
Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model Research Published on 2022-03-172022-10-05 Journal: Communications Biology [Category] 바이오마커, [키워드] attribute BDNF Blood Blood brain barrier Brain brains Cell cell proliferation Concentration correlated decrease dendritic downstream Effect ENhance Express expression growth HIV intranasal intranasally memory neurons neurotoxic Newborn powerful tool promote Protein receptor reducing regenerative severity Signaling survival therapeutic tropomyosin [DOI] 10.1038/s42003-022-03177-3 [Article Type] Research
First-in-class trispecific VHH-Fc based antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 and variantsSARS-CoV-2 및 변이체에 대한 강력한 예방 및 치료 효능을 지닌 동급 최초의 삼중특이성 VHH-Fc 기반 항체Article Published on 2022-03-092022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, [키워드] ACE-2 addition antibody Antibody therapy cellular characterized comparable COVID-19 cases COVID-19 pandemic COVID-19 vaccination death Delta demonstrated distribution Drug development Efficacy Efficacy and safety epitope evaluated feature greatly reduce hospitalizations humanized Immunity in vitro in vivo intranasal lead Measures multiple epitope omicron parameter PBS prevented Prophylactic Prophylaxis provided reduced reported safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants shown tested the vaccine the vaccines therapeutic efficacy Treatment treatment for COVID-19 variant Viral Viral load viral loads while [DOI] 10.1038/s41598-022-07952-4 PMC 바로가기 [Article Type] Article
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 ExpressionK18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다Article Published on 2022-03-052022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viremia Virological [DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2차세대 COVID-19 백신의 호흡기 점막 전달은 SARS-CoV-2의 조상 및 변이 균주 모두에 대해 강력한 보호를 제공합니다Article Published on 2022-03-032022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adenoviral vector adenoviral vectors Administered animal models antibody Antigen B.1.1.7 B.1.351 chimpanzee adenoviral vector COVID-19 COVID-19 vaccine develop effective Effectiveness evaluated expressing human adenoviral vector humoral Humoral immunity Immunity immunization induce Innate immunity intramuscular intramuscular immunization intramuscularly intranasal Local long-lasting memory T cell memory T cells mucosal multi-valent vaccine multivalent vaccine murine models next-generation vaccines nucleocapsid protective immunity provide RdRP respiratory respiratory mucosal immunity respiratory mucosal immunization responses robust SARS-CoV-2 SARS-CoV-2 variant Single-dose Spike protein strain T cell T cell immunity T cells the spike protein trained innate immunity trivalent Vaccine variant variants variants of concern VoC VOCs [DOI] 10.1016/j.cell.2022.02.005 PMC 바로가기 [Article Type] Article
A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice명반을 포함하는 RBD 기반 COVID-19 백신 제형의 새로운 박테리아 프로테아제 억제제 보조제는 중화 항체, 특정 배아 중심 B 세포를 증가시키고 마우스에서 SARS-CoV-2 감염에 대한 보호를 제공합니다Article Published on 2022-02-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant adjuvants Against Alpha alum Antigen B cell Brucella CD8 center clinical development Combination composed Containing coronavirus COVID-19 evaluated Formulation Frequency Germinal Germinal center germinal center cells increase intranasal K18-hACE2 mice Lungs mucosal neutralization capacity neutralizing antibody novel plasmablasts Protease inhibitor protection RBD Receptor binding domain respiratory Result SARS- CoV-2 SARS-CoV-2 significantly increased Specific spleen T-cell Response T-cell responses Th1 the vaccine U-Omp19 Vaccine variant virus [DOI] 10.3389/fimmu.2022.844837 PMC 바로가기 [Article Type] Article
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern경구 프로테아제 억제제(PF-07321332)는 우려되는 SARS-CoV-2 변종 감염으로부터 시리아 햄스터를 보호합니다Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] 3CLpro Air-liquid interface Alpha Alpha variant animals Anti-viral Antiviral Antiviral agents B.1.351 B.1.617.2 Beta clinical development clinical trials dosed epithelial cell epithelial cells Evidence evidence of golden hamster golden hamsters hamster in vitro activity Infection infection with SARS-CoV-2 inhibitor intranasal MPro PF-07321332 Pfizer prevented primary human airway Primary human airway epithelial cells protease Protease inhibitor PROTECT reduced Replication SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selective Syrian Golden hamsters target Transmission Treatment variant variants of concern Viral viral replication [DOI] 10.1038/s41467-022-28354-0 PMC 바로가기 [Article Type] Article