Molecular characterization of SARS-CoV-2 from Bangladesh: implications in genetic diversity, possible origin of the virus, and functional significance of the mutationsResearch Article Published on 2021-08-212022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] accompanied Analysis ancestor B-cell Bangladesh China Chittagong circulating clade Clinical data Complete country COVID-19 COVID-19 pandemic CpG D614G Deletion Diagnosis downloaded Epidemiology epitope European country evade event Evolution functional genetic diversity Genome genome sequence Genome sequencing genomic change GISAID GISAID database Host immune response implication include India insertions isolate isolates less Missense Missense mutation MOST Mutation mutations Nextstrain nucleotide occurred ORF7a ORF8 gene P323L Pathogenesis PCR Phylogeny predict predicted prevalent RdRP reduce reference sequence Region reported reveal RT-PCR SARS-CoV-2 SARS-CoV-2 genome selective sequence severity single nucleotide variations Spike protein submitted synonymous T-cell target region the disease the SARS-CoV-2 virus unique variant viral clearance viral replication virus Wuhan [DOI] 10.1016/j.heliyon.2021.e07866 PMC 바로가기 [Article Type] Research Article
Trends of Multidrug-Resistant Pathogens, Difficult to Treat Bloodstream Infections, and Antimicrobial Consumption at a Tertiary Care Center in Lebanon from 2015–2020: COVID-19 AftermathArticle Published on 2021-08-212022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] Acinetobacter baumannii and COVID-19 analyzed antimicrobial antimicrobial resistance antimicrobial stewardship in COVID-19 Bacteremia Blood BSI calculated carbapenem Care center Consumption Corynebacterium COVID-19 CRE Culture cultures Difficult E. coli Enterobacteriaceae Epidemics excluded exclusion criteria Infection prevention Infectious disease isolate isolates Isolation material MDR and COVID-19 organism P -value P. aeruginosa pandemic Patient pneumoniae Result Saint George significant decrease Staphylococcus Staphylococcus epidermidis susceptibility Tertiary the SARS-CoV-2 Total trend unique university VRE and COVID-19 worsened [DOI] 10.3390/antibiotics10081016 PMC 바로가기 [Article Type] Article
Validation of the Thermo Scientific™ SARS-CoV-2 RT-PCR Detection Workflow for the Detection of SARS-CoV-2 from Stainless-Steel Environmental Surface Swabs: AOAC Performance Tested MethodSM 012103스테인리스강 환경 표면 면봉에서 SARS-CoV-2 검출을 위한 Thermo Scientific™ SARS-CoV-2 RT-PCR 검출 워크플로 검증: AOAC 성능 테스트 방법SM 012103Article Published on 2021-08-202022-09-11 Journal: Journal of AOAC International [Category] SARS, 치료기술, 치료제, [키워드] 2019-nCoV Analysis analyzed Applied Biosystem Applied Biosystems assays CDC center Chain Reaction comparable Control detection disease disease control effective Emergency evaluated Genome genomic region homology in silico analysis instruction isolates N-gene ORF1 ORF1ab Organisms packaged Panel PCR reaction performance platform prevention provide response revision RNA RNA extraction RT-PCR S-gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RT-PCR SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 virus specificity stainless steel Strains surface TaqMan target tested the SARS-CoV-2 Thermo Thermo Scientific validation [DOI] 10.1093/jaoacint/qsab050 PMC 바로가기 [Article Type] Article
Molecular docking and dynamic simulation of conserved B cell epitope of SARS-CoV-2 glycoprotein Indonesian isolates: an immunoinformatic approachResearch Article Published on 2021-08-162022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome addition Antigen antigenic approach B cell B cell epitope BCR binding Brazil calculated Candidates carried CD4+ cell China complex conserved conserved region. coronavirus country COVID-19 differentiation docking epitope gene sequence GISAID histocompatibility complex HLA Immunoinformatic India Indonesia Infectious disease investigated isolate isolates leukocyte lowest memory response MHC-II molecular NCBI non-toxic peptide predicted produced receptor Region SARS-CoV-2 SARS-CoV-2 glycoprotein SARS-CoV-2 isolate SARS-CoV-2 spike glycoprotein sequence South Africa spike glycoprotein T cell The United States the vaccine Toxicity United Kingdom Vaccine vaccine candidate Virus neutralization Wuhan [DOI] 10.12688/f1000research.54258.1 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial CellsSARS-CoV-2 분리주는 인간 면역 세포에서 손상된 복제를 보여주지만 폐 상피 세포에서 복제하고 타고난 면역을 유도하는 차등 능력을 보여줍니다Research Article Published on 2021-08-112022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Calu Calu-3 cell calu-3 cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines dendritic cells epithelial epithelial cells Finnish Gene Expression HCoV Human human cell human cells human DC human lung human macrophage IFN IFNs Immune cell immune cells Impaired induce infect Infection Inflammatory response Inflammatory responses information Innate Innate immunity interferon interferon (IFN) response interferon response interferons interferons (IFNs interferons (IFNs) isolate isolates knowledge lung epithelial cell Lung epithelial cells Lymphocytes macrophages mechanism Monocytes open organ pandemic Pathogenesis pathogenesis of SARS-CoV-2 regulate Regulation replicate replicated Replication respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus show Spread target organ TPCK-treated trypsin type I Type III IFN Vero E6 cell viral replication [DOI] 10.1128/Spectrum.00774-21 PMC 바로가기 [Article Type] Research Article
Paradigm Shift in Antimicrobial Resistance Pattern of Bacterial Isolates during the COVID-19 PandemicArticle Published on 2021-08-072022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] antibiotic antibiotic use Antibiotics antimicrobial antimicrobial resistance Bacterial bacterial co-infection bacterial pathogen Blood blood sample Care clinician COVID-19 COVID-19 cases COVID-19 pandemic COVID-19 patient Department develop Escherichia coli evaluate help highlight hospital Hospital staff Hospitalized hospitals ICU ICUs IMPROVE increase in India infection control investigated irrational consumption isolate isolates maintain mechanism medication Microbiology MRSA negative observé occurred pandemic paradigm pathogen Pathogens patients with SARS-CoV-2 pattern positive processed public health resistance Respiratory illness shift single-center study Staphylococcus Staphylococcus aureus Surveillance Urine use of antibiotics [DOI] 10.3390/antibiotics10080954 PMC 바로가기 [Article Type] Article
Assessment of basic reproduction number (R 0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh방글라데시 SARS-CoV-2의 기본 생식 수(R 0), 공간 및 시간 역학 결정인자 및 유전적 특성 평가Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술, 치료법, [키워드] Analysis assessment B.1 B.1.1 basic reproduction number calculated Case fatality rate circulating clade Cluster continuous monitoring country COVID-19 cumulative D614G detect determinants distribution effective Effectiveness epidemiological evaluate exponential growth Fatality rate Genetic Genome genomic Genomic analysis Genomic surveillance highest incidence of COVID-19 Infection isolates Lineage Local molecular molecular characteristics Molecular epidemiology Mutation Non-synonymous NSP11 NSP2 Nsp9 nucleocapsid nucleocapsid protein P323L pandemic Pangolin lineage performed Phylogenetic Phylogenetic analysis prediction predominant projection Protein RdRP SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 strain sequence spike Spread strain Strains subsequent Surveillance Transmission dynamics unique vaccination variants of SARS-CoV-2 variations virus was recorded were recorded [DOI] 10.1016/j.meegid.2021.104884 PMC 바로가기 [Article Type] Article
D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike CleavageSARS-CoV-2 스파이크 단백질의 D614G 대체는 강화된 푸린 매개 스파이크 절단을 통해 융합체 형성 및 바이러스 역가를 증가시킵니다Research Article Published on 2021-07-272022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Cell cleavage coronavirus D614G D614G substitution enhanced enhancement expressing S protein Formation furin furin cleavage site furin inhibitor increase isolates mechanism Mutation Plaque assay promote Protein rapid expansion respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus significantly higher spike Substitution syncytium syncytium formation the S protein titer Transmissibility Treatment variant Viral viral isolate virus titer [DOI] 10.1128/mBio.00587-21 PMC 바로가기 [Article Type] Research Article
CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In VitroCAR-NK 세포, 시험관 내에서 SARS-CoV-2-스파이크 발현 세포주를 효과적으로 표적화Immunology Published on 2021-07-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus addition adverse effect Anticoagulants antigen receptor antivirals approach Cancer CAR CAR (chimeric antigen receptor) Cell cells chimeric antigen receptor conserved conserved region contagious convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CR3022 current cytokine cytokine production D614G domain E484K E484K variant effective Emergency use escape mutant escape mutants Evidence expressing glycoprotein hematologic immune pressure immune response Immunity immunocompromised condition immunodeficient patients immunomodulators Immunotherapy IMPROVE in vitro include individual isolates kill killing LINE Moderna monoclonal antibody monoclonal antibody therapies mutants N501Y N501Y variant NAbs natural killer neutralizing antibody NK cells off-the-shelf Patient Pfizer Population pseudotyped SARS-CoV-2 virus public health recognize reported respiratory S protein S309 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 virus scFv Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Side effect target target cell target cells the vaccines Therapies therapy treat treating COVID-19 Treatment Vaccine Vaccines variants of SARS-CoV-2 [DOI] 10.3389/fimmu.2021.652223 PMC 바로가기 [Article Type] Immunology
Pre- and post-COVID-19 evaluation of antimicrobial susceptibility for healthcare-associated infections in the intensive care unit of a tertiary hospitalShort Communication Published on 2021-07-232022-10-28 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] Coronavirus, SARS, [키워드] analyzed antimicrobial resistance Bacterial resistance changed COVID-19 Healthcare related infection hospital ICU Infection intensive care involved isolates Klebsiella pneumoniae pandemic pathogen Patient Polymyxin B reported severe COVID-19 susceptibility worsened [DOI] 10.1590/0037-8682-0090-2021 PMC 바로가기 [Article Type] Short Communication