Pausing the Fight Against Malaria to Combat the COVID-19 Pandemic in Africa: Is the Future of Malaria Bleak?Microbiology Published on 2020-06-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] access ACE2 acute respiratory syndrome affected Against antimalarial Asymptomatic caused Chemotherapy children combat coronavirus coronavirus disease Coronaviruses country COVID-19 COVID-19 pandemic died distribution effort epidemiological Future Health healthcare highest implementation killing less lockdowns malaria malaria control medication Mortality Perspective phase Plasmodium Pneumonia Rapid diagnostic test RDT RDTs Region regions reported resulting SARS-CoV-2 sub-Saharan Africa Symptom Treatment tropical Vaccine Wuhan, China [DOI] 10.3389/fmicb.2020.01476 PMC 바로가기 [Article Type] Microbiology
Analysis of Outbreak and Global Impacts of the COVID-19Article Published on 2020-05-292022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] Affect affected affecting Antarctica bats caused China Corona virus country COVID-19 COVID-19 outbreak death deaths global impacts global pandemic globe Human Impact infect killing measure observation outbreak pandemic raised regions Severe acute respiratory syndrome (SARS) Spread the disease the vaccine Travel Treatment Vaccine virus while Wuhan, China [DOI] 10.3390/healthcare8020148 PMC 바로가기 [Article Type] Article
Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 InfectionImmunology Published on 2020-05-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress addition ARDS Care caused clinical trial combined treatment Complication complications coronavirus Coronavirus infection COVID-19 Cytokine storm direct infection Effect global healthcare global pandemic Guidance hematopathologic effect Host immune response immune Immune cell immune response immune responses immune therapy infection mechanism infection-induced lymphopenia Invasion killing mechanism medication MERS-CoV molecular mechanism Novel coronavirus outbreak Patient Potential treatment Prevent Prophylactic pulmonary fibrosis reduce Replication required response responses resulting risk SARS-CoV SARS-CoV-2 SARS-CoV-2 infected patient Severe case severe respiratory syndrome Spread syndrome the disease Therapeutic approach therapeutic approaches therapy Vaccine Vaccine development Wuhan, China [DOI] 10.3389/fimmu.2020.01022 PMC 바로가기 [Article Type] Immunology
Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistanceAspergillus fumigatus 칼슘 반응성 전사 인자는 스트레스 내성, 독성 및 카스포펀진 내성을 촉진하는 세포벽 구조를 조절합니다Research Article Published on 2019-12-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activated macrophage activated macrophages Activation aspergillosis Aspergillus fumigatus calcineurin calcium calcium metabolism Calcium signaling cause caused Cell cell wall complexity Complicating disease contribute disease disease control drug drug-resistant drugs echinocandin expression functions fungal fungal cell wall fungal cell walls fungal disease gene networks Host host infection humans identify immune response immune responses increasingly Infection influence inhibit inhibitors invasive involved killing life-threatening Localization Lungs Macrophage macrophages mechanism metabolism mice modifications modulating morphology mutant Neutrophils nine osmotic Pathogenesis Pathogens pathway phosphatase polysaccharide pro-inflammatory pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promoted reduction in regulate regulated Regulation response responses Screen signaling pathway strain Strains Stress stress response stress response mechanisms stress responses susceptible Tolerance transcription factor transcription factors transcriptomics Treatment turn unique virulence wild-type [DOI] 10.1371/journal.pgen.1008551 PMC 바로가기 [Article Type] Research Article
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype구강 인두 감염 동안 Candida albicans 삼염색체를 선택하면 공생 유사 표현형이 나타납니다.Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Acute stress adhere Affect allelic Alter amplification analyzed antifungal agents Author benefit Candida Candida albican Candida albicans caused change Characteristics chromosome chromosomes clone clones commensal conserved de novo de novo mutation de novo mutations determine diploid elicited epithelial cell epithelial cells exhibited exposure to expression facilitate Frequency functional fungal fungal pathogen fungal pathogens fungus Genome growth Host host response in vitro in vivo Infection Inflammatory Interaction isolate killing less Lineage mice MOST mouse model much higher mutations neutrophil oral infections Oropharyngeal Pathogens phenotype Phenotypes Post-infection proliferate recognize reduced respond selected Selection significantly significantly lower strain Strains subsequent susceptibility These data tongue trisomy virulence weight loss while Whole genome sequencing [DOI] 10.1371/journal.pgen.1008137 PMC 바로가기 [Article Type] Research Article
CDI/CDS system-encoding genes of Burkholderia thailandensis are located in a mobile genetic element that defines a new class of transposonBurkholderia thailandensis의 CDI/CDS 시스템 인코딩 유전자는 새로운 종류의 트랜스포존을 정의하는 이동성 유전 요소에 있습니다.Research Article Published on 2019-01-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition allele Bacteria Bacterial Burkholderia CDS Cell cells Characteristics chromosome Community community development composed cooperation Critical DNA dsDNA element Escherichia coli Evidence facilitate fitness functional Genes genes encoding Genetic genetic material growth helping immune Immunity induce inhibit insertion insertion sequence Interaction Intercellular communication involved killing lack left mechanism microbial Microbial communities Mobility occur Organisms phenomenon Phenotypes Propagation Protein provide reaction required self sequence sequences Signaling Support synthesis target cell transposon turn [DOI] 10.1371/journal.pgen.1007883 PMC 바로가기 [Article Type] Research Article
Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective EfficacyArticle Published on 2018-06-272022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Asia baculovirus baculovirus display system Clinical signs clinical symptom complex control group control groups demonstrated disease display displaying effective elicited epidemic diarrhea exhibited experiment fecal full-length S protein generate Genotype IgG immune response immunization immunized immunogen immunogenicity Infection Intramuscular injection killing less mice Mild mimicking Modification Neonatal neutralizing antibody North America PEDV Protein robust Safe significantly significantly higher spike spike vaccine Taiwan the S1 protein vaccine candidate variant viral shedding virulent virus [DOI] 10.3390/v10070346 PMC 바로가기 [Article Type] Article
A novel mechanism of RNase L inhibition: Theiler’s virus L* protein prevents 2-5A from binding to RNase LResearch Article Published on 2018-04-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] accumulate activate activating Activation Antiviral antiviral response Apoptosis ATP bind binding Cell cellular Central nervous system chimeric contributing to Coronaviruses degrade double-stranded RNA effective enzyme expressing flu IFN in vivo inactive infected cell infected cells Infection inhibit interferon killing mechanism MHV mouse hepatitis virus murine OAS oligomerization pathway Pathways Prevent produced promote Protein Replication RNase these cell triggering upstream Viral protein Viral RNA virus virus replication virus spread [DOI] 10.1371/journal.ppat.1006989 PMC 바로가기 [Article Type] Research Article
Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다Research Article Published on 2018-04-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast [DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article
The microbiota protects against respiratory infection via GM-CSF signaling미생물군은 GM-CSF 신호 전달을 통해 호흡기 감염으로부터 보호합니다Article Published on 2017-11-152022-09-14 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 폐렴구균 감염증, [키워드] Actinobacteria activate activating airway alveolar macrophage Bacteria Bacteroidetes clearance Clostridium Defense defined ENhance Enterococcus Extracellular firmicutes GM-CSF Gut Host human pathogen identify identity Immunity Increased Infection interleukin-17A intestinal killing Klebsiella pneumoniae lactobacillus lung Lung infection mechanisms mice microbiota pathogen promote PROTECT Proteobacteria regulate respiratory infection Signaling Staphylococcus aureus Staphylococcus epidermidis stimulate Streptococcus pneumoniae [DOI] 10.1038/s41467-017-01803-x PMC 바로가기 [Article Type] Article