Decrease in Admissions and Change in the Diagnostic Landscape in a Newborn Care Unit in Northern Ghana During the COVID-19 PandemicPediatrics Published on 2021-03-252022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Admission Anomaly approaches Care carried change continuum coronavirus disease COVID-19 cross-sectional decrease Diagnosis evaluate health system identify Immediate Infection intensive care unit lack landscape likelihood Logistic regression lowest Measures morbidity and mortality Mortality multivariate Neonatal infection Neonatal Mortality Neonate Neonates Newborn Newborn care NICU northern Ghana pandemic pandemic impact Patient patients predictor pregnant women Spread Tamale Teaching unit urgency vaginal delivery was performed [DOI] 10.3389/fped.2021.642508 PMC 바로가기 [Article Type] Pediatrics
Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma PatientsArticle Published on 2021-03-122022-10-31 Journal: Cancers [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome adenocarcinoma alveolar alveolar epithelial cells Analysis AT2 Cancer CD36 Cell cells cellular distribution Clinical management co-expressed Cohort coronavirus coronavirus disease COVID-19 COVID-19 pandemic death rates Defense DMBT1 elevated enzyme epithelial cell examined Express expressed expression expression level expression profile Features Genes Health HHIP highest Host host protein identify implicated individual Inflammation landscape lung lung adenocarcinoma lung cancer patient lung cancer patients lung cell lung cells lung epithelial Lung epithelial cells Lung inflammation lung neoplasms malignant marker Mortality normal novel coronavirus SARS-CoV-2 offer pandemic pathway patients patients with comorbidity Pneumonia Population positively correlated Potential treatment presenting Proteases proteases Tmprss2 pulmonary raising receptor Respiratory complications Respiratory failure risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 receptor scRNA-seq significantly simple single-cell Single-cell RNA sequencing Single-cell RNA-sequencing Spread symptomatic target the United State therapeutic target tissue TMPRSS2 TMPRSS4 [DOI] 10.3390/cancers13061250 PMC 바로가기 [Article Type] Article
Oligomannose N -Glycans 3D Architecture and Its Response to the FcγRIIIa Structural LandscapeArticle Published on 2021-03-042022-10-29 Journal: The journal of physical chemistry. B [Category] Coronavirus, SARS, [키워드] 3D structure ADCC antibody-dependent cellular cytotoxicity architecture Arm binding affinity complex conformation conformational cumulative Effect experimental evidence FcγRIIIa feature form function glycan glycosylated glycosylation HIV-1 IgG1 Immune escape intrinsically involved landscape mammalian Man modulate molecular processed promote Protein receptor response SARS-CoV2 steric Structure Support vertebrates viruses yeast [DOI] 10.1021/acs.jpcb.1c00304 PMC 바로가기 [Article Type] Article
Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck집 고양이에서 SARS-CoV-2의 전파는 좁은 병목 현상을 초래합니다Research Article Published on 2021-02-262022-08-13 Journal: PLoS Pathogens [Category] MERS, 변종, 유전자 메커니즘, 진단, [키워드] accelerated adaptive Amino acid amino acid position antigenic evolution arise bottleneck cats defined distribution escape event Evolution fixation fixed followed by Genetic genetic drift Genetic variation genomic H655Y Host hosts Human human monoclonal antibodies Human monoclonal antibody identify Infection intermediate frequency involved landscape mammalian mechanism model systems new infections new SARS-CoV-2 notable persist Positive selection reveal RNA virus SARS-CoV-2 SARS-CoV-2 consensus sequence SARS-CoV-2 consensus sequences SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus SARS-CoV-2 viruses scrutiny selected shown species spike Surveillance Therapeutics this system Transmission transmitted undergo Vaccine variant viruses [DOI] 10.1371/journal.ppat.1009373 PMC 바로가기 [Article Type] Research Article
Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 PatientsImmunology Published on 2021-02-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Accessibility accompanied Activation Analysis approaches CD4 CD69 CD8 Cell Characteristics chromatin chromatin accessibility Control coronavirus diseases COVID-19 creating Critical element enhancer Epigenetic expressed function Genes HCs healthy HLA class II HLA-DRA HLA-DRB1 HLA-DRB5 immune Immune profile infected with COVID-19 inflammatory genes inflammatory pathways inflammatory state involved key factor landscape less MAPK moderate mononuclear cell motif Necrosis NFKBIA nine Pathogenesis Patient patients with COVID-19 PBMCs performed Peripheral blood PIK3R1 profile profiles promoter proportion Protein provided regions RNA S100A9 SARS-CoV-2 scATAC-seq scRNA-seq ScRNA-seq analysis seq Sequencing signaling pathway significantly Single Cell single-cell T cell T cells T-cell TBX21 Th1 TNF transcriptome profiling transcriptomic upregulated were used [DOI] 10.3389/fimmu.2021.625881 PMC 바로가기 [Article Type] Immunology
Comprehensive Landscape of Heparin Therapy for COVID-19COVID-19에 대한 헤파린 요법의 종합적인 전망Review Published on 2021-02-152022-09-11 Journal: Carbohydrate polymers [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration adverse effect adverse effects Anti-inflammation Anti-inflammatory Anticoagulant anticoagulant agent anticoagulation antiviral activities antivirus binding biochemical caused cells clinical clinical observation clinical observations Comprehensive concerning coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect Effectiveness Evidence heparin in vitro study Infection landscape observation pandemic coronavirus pharmacological mechanism Protein public health emergency pulmonary thrombosis respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein systemic symptom systemic symptoms the Spike therapy thrombosis Viral viral infection [DOI] 10.1016/j.carbpol.2020.117232 PMC 바로가기 [Article Type] Review
Landscape Profiling Analysis of DPP4 in Malignancies: Therapeutic Implication for Tumor Patients With Coronavirus Disease 2019Oncology Published on 2021-02-042022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome analyzed binding bioinformatics cancer patient cancer type caused cellular changes in characterized complications coronavirus coronavirus disease correlation COVID-19 Critical Cytokine storms datasets demonstrated Dipeptidyl peptidase 4 DPP4 enzyme II estimation expression expression levels healthy immune Immune cell Immunity immunopathological infiltrating landscape lymphopenia malignancies malignancy marker Patient patients pharmacological Pneumonia positively correlated Profiling profiling analysis receptor risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment Support susceptibility therapeutic effect tissue Tumor underlying conditions [DOI] 10.3389/fonc.2021.624899 PMC 바로가기 [Article Type] Oncology
More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation유전자 치료 벡터 그 이상: 혈청학적 조사를 위한 Lentiviral Vector PseudotypesReview Published on 2021-01-312022-09-01 Journal: Viruses [Category] MERS, 진단, 치료기술, 치료제, [키워드] Above Analysis Anti-viral Cell culture cell entry characterization COVID-19 pandemic culture system envelope envelope protein evaluate flexibility handling immune response immune responses Infection investigation landscape lentiviral lentiviral vectors lentivirus Neutralising Antibodies neutralising antibody Outbreaks Protein pseudotype pseudotyped sequence serological Serological assay serological assays serology shown speed Surrogates target vaccination Vaccines vector Viral viral surface virus viruses [DOI] 10.3390/v13020217 PMC 바로가기 [Article Type] Review
The Immunopathological and Histological Landscape of COVID-19-Mediated Lung InjuryReview Published on 2021-01-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] “cytokine storm” abnormality acute respiratory syndrome alteration Autopsy blood vessels clinical impact collected Complete coronavirus coronavirus disease COVID-19 COVID-19-related death COVID19 Cytokine storm Factors highest histopathological feature IMPROVE landscape lesion lung mechanism Morphological non-specific outcome pathology patients SARS-CoV-2 Treatment [DOI] 10.3390/ijms22020974 PMC 바로가기 [Article Type] Review
Microfluidic Point-of-Care Testing: Commercial Landscape and Future DirectionsBioengineering and Biotechnology Published on 2021-01-152022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] acid amplified Cardiac markers cholesterol COVID-19 COVID-19 diagnostics COVID-19 pandemic detect diagnose diagnostic diagnostics direction disease faster Flow Future Glucose In-vitro Infectious disease IVD landscape Lateral LFA Microfluidics NAATs Numerous physician POCT point-of-care diagnostics point-of-care test Pregnancy the patient [DOI] 10.3389/fbioe.2020.602659 PMC 바로가기 [Article Type] Bioengineering and Biotechnology