Tocilizumab and COVID-19: a meta-analysis of 2120 patients with severe disease and implications for clinical trial methodologiesTocilizumab 및 COVID-19: 중증 질환을 가진 2120명의 환자에 대한 메타 분석 및 임상 시험 방법론에 대한 의미Meta-Analysis Published on 2021-06-282022-09-12 Journal: Turkish Journal of Medical Sciences [Category] MERS, SARS, 진단, [키워드] 95% CI actemra benefit bioRxiv Characteristics clinical trial ClinicalTrials Cochrane Central conducted control group coronavirus COVID-19 COVID-19 patient Cytokine storm syndrome Descriptive analysis implication lower mortality material mechanical ventilation medRxiv Meta-analysis methodology Mortality outbreak Patient patients Registered Result severe disease Therapeutic benefit therapeutic benefits therapy Tocilizumab treatment group Trial trials [DOI] 10.3906/sag-2010-131 PMC 바로가기 [Article Type] Meta-Analysis
Antimicrobial Use in COVID-19 Patients in the First Phase of the SARS-CoV-2 Pandemic: A Scoping ReviewReview Published on 2021-06-192022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] antibiotic antibiotic use Antibiotics antimicrobial bacterial co-infection clinical evidence clinical justification COVID-19 COVID-19 patient COVID-19 patients Critical discharge rate disease severity Evidence Hospital stay identify lower mortality Mild moderate Moderate COVID-19 Open Science Framework pandemic Patient phase Prevalence proportion protocol provide provided Registered review secondary infections severity the SARS-CoV-2 Treatment Treatment outcome were given [DOI] 10.3390/antibiotics10060745 PMC 바로가기 [Article Type] Review
Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19Research Article Published on 2021-06-162022-10-30 Journal: International Journal of Endocrinology [Category] COVID-19, [키워드] age binomial control group demonstrated determine diabete diagnosed Evidence group had no hospitalized patient hyperglycemia Impact Infection less lower mortality mechanical ventilation Mortality not affect older patient outcome outcomes Patient patients with COVID-19 Prediabete predictor Presence regression analysis Result retrospective SARS-COV-2 infection significantly higher single-center survival three group type-2 diabete type-2 diabetes was used with COVID-19 younger patient [DOI] 10.1155/2021/5516192 PMC 바로가기 [Article Type] Research Article
The association between opioids, environmental, demographic, and socioeconomic indicators and COVID-19 mortality rates in the United States: an ecological study at the county levelResearch Published on 2021-06-152022-10-27 Journal: Archives of Public Health [Category] COVID-19, [키워드] 95% CI adjusted Air pollution association average covariates COVID-19 COVID-19 mortality COVID-19 pandemic cumulative death ecological Ecological study effort evaluate Future health inequities impacted indicate inferences lower mortality matter Mortality mortality rate ratio multivariable opioids outcome pandemic Particulate percentage public health rate ratio Region Regression model Research Result risk significantly significantly higher Socioeconomic factor Spread temperature were used [DOI] 10.1186/s13690-021-00626-z PMC 바로가기 [Article Type] Research
COVID-19 treatment combinations and associations with mortality in a large multi-site healthcare systemCOVID-19 치료 조합 및 대규모 다중 사이트 의료 시스템에서 사망률과의 연관성Observational Study Published on 2021-06-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단, 치료제, [키워드] accounted adjusted Admissions Anticoagulants anticoagulation association Care changes in Characteristics Clinical characteristics Combination combinations conducted Corticosteroid Corticosteroids COVID-19 COVID-19 pandemic declined decrease decreased mortality demographics determine evaluate explain Factor Healthcare system Hydroxychloroquine identify intensive care intensive care unit Logistic regression lower mortality medication Mortality mortality rate multivariable logistic regression overtime Patient patients pharmacological intervention pharmacological interventions predictor reduction Remdesivir Result retrospective cohort study significant decrease significantly Standard of care stratified the disease The United States Tocilizumab Treatment United States variable was used were used [DOI] 10.1371/journal.pone.0252591 PMC 바로가기 [Article Type] Observational Study
Trends in Venous Thromboembolism Anticoagulation in Patients Hospitalized With COVID-19Research Published on 2021-06-112022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted hazard ratio adjusted odds ratio adults hospitalized age analyzed Anticoagulant anticoagulation anticoagulation treatment association Black patients cohort of patient cohort study complication of COVID-19 COVID-19 defined dissemination dose Evidence exposure finding Frequency hospital Hospitalization Hospitalized hospitals implementation Importance In-hospital in-hospital mortality logit lower mortality measure median Missed Mortality mortality rates multicenter objective participant Patient patients hospitalized patients with COVID-19 Point Probability Prophylactic prophylactic dose Prophylaxis ranged Relevance remained Result setting therapy Thromboembolism treated Treatment trend Variation Venous Thromboembolism VTE Weighting with COVID-19 women [DOI] 10.1001/jamanetworkopen.2021.11788 PMC 바로가기 [Article Type] Research
Clinical features and outcomes of hospitalized COVID-19 patients in a low burden region저부담 지역 입원한 코로나19 환자의 임상 양상 및 결과Observational Study Published on 2021-06-012022-09-11 Journal: Pathogens and global health [Category] SARS, 임상, 치료제, [키워드] Admission age Analysis Chest chest X-ray clinical Clinical data clinical feature Clinical features Comorbidity country COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Critical disease death died disease European country Factor feature Greece hospital hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hypertension ICU ICU admission ICU care Immunosuppression In-hospital death independent predictor independent predictors independent risk factor independent risk factors intensive care unit invasive ventilation lower mortality lung field male median medical record medical records Mortality multivariable logistic regression outbreak outcome pandemic Patient patients hospitalized Pneumonia Region reported required Respiratory failure Retrospective study SARS-CoV2 Solid solid tumor the disease thrombocytopenia Tumor univariable [DOI] 10.1080/20477724.2021.1893485 PMC 바로가기 [Article Type] Observational Study
COVID-19 mortality risk factors in older people in a long-term care center장기 요양원에 있는 노인의 COVID-19 사망 위험 요인Article Published on 2021-06-012022-09-11 Journal: European Geriatric Medicine [Category] SARS, 치료제, [키워드] Analysis Azithromycin bivariate analysis Care Case fatality rate cognitive Cohort collected conducted confirmed case Course COVID-19 COVID-19 infection COVID-19 mortality demographics Factor Fatality rate female Fever frailty Gender Hydroxychloroquine hydroxychloroquine plus azithromycin identify independent risk factor independent risk factors Infection information Laboratory Logistic regression Logistic regression analysis Long-term care lower mortality lymphocytopenia male median age Mortality multivariate multivariate logistic regression multivariate logistic regression analysis nursing home nursing homes Older older patient outcome pandemic patients pharmacological treatment predict Prognosis Prognostic factor reported respiratory symptoms Retrospective analysis risk factor Risk factors significantly study period survival therapeutic treated Treatment [DOI] 10.1007/s41999-020-00432-w PMC 바로가기 [Article Type] Article
Decreased Mortality in Coronavirus Disease 2019 Patients Treated With Tocilizumab: A Rapid Systematic Review and Meta-analysis of Observational StudiesTocilizumab으로 치료받은 코로나바이러스 질병 2019 환자의 사망률 감소: 관찰 연구의 신속한 체계적 검토 및 메타 분석Meta-Analysis Published on 2021-06-012022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 95% CI 95% confidence interval antagonist Cochrane Library control group coronavirus disease COVID-19 COVID-19 patient death Decreased Effect favor IL-6 IL-6 receptor IL-6 receptor antagonists increased risk index lower mortality Meta-analysis Mortality no difference Patient PMC prevented PubMed Central Randomized controlled trials Rapid receptor reduce mortality Research retrieved review risk risk ratio searched Side effect Side effects TCZ therapy Tocilizumab treat treated unique was used Web of Science World Health Organization [DOI] 10.1093/cid/ciaa1445 PMC 바로가기 [Article Type] Meta-Analysis
Outcomes of patients with end stage kidney disease on dialysis with COVID-19 in Abu Dhabi, United Arab Emirates; from PCR to antibody아랍에미리트 아부다비에서 코로나19 투석을 받은 말기 신장질환 환자의 결과; PCR에서 항체로Research Published on 2021-05-262022-09-01 Journal: BMC Nephrology [Category] SARS, 진단, 치료제, [키워드] Abu addition age antibody Antibody Response Antibody responses Asymptomatic average average age camostat characteristics of patient Cohort combinations Community Comorbidities concerning Contact contributed cough country COVID 19 COVID-19 COVID-19 infection COVID19 Critical care defined demographics develop diabete diabetes dialysis disease drug End stage kidney disease examined family Favipiravir Haemodialysis heart disease Hydroxychloroquine hypertension ICU IgG antibody individual infected individual infected individuals Infection Ischaemic heart disease Isolation Kidney disease lack Local Lopinavir lower mortality majority male median time Mild Mild disease Mortality Most patients negative PCR test outcome overall mortality Patient patients PCR PCR positive patient PCR positivity PCR tests performed Population positive patient positive patients presenting symptoms Rapid required Result Ritonavir Screening screening strategy serology source of infection spread of COVID-19 steroid Steroids study period subset symptomatic tested the antibody response Tocilizumab Viral viral clearance was performed were used with COVID-19 [DOI] 10.1186/s12882-021-02378-y PMC 바로가기 [Article Type] Research