Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortemsCOVID-19 사후 부검에서 일치하는 폐 샘플의 섬유화 진행 및 방사선학적 상관관계Original Article Published on 2020-09-282022-09-10 Journal: Virchows Archiv [Category] SARS, 치료법, [키워드] alveolar alveolar damage Analysis approach category changes in Computed tomography consolidation correlated correlation COVID-19 COVID-19 patient COVID-19 patients death died Diffuse alveolar damage disease eight enrolled Evolution Features fibrosis Follow-up ground-glass opacity histologic histologic finding histologic findings Histopathologic analysis illness duration immunohistochemistry implication information Intubated lesion lesions lobes lung Lung fibrosis lung lesions lung lobe lung tissue lung tissues mechanically ventilated median pathologic pathology Patient positive Post-mortem progression Protein radiologic Radiologic patterns SARS-CoV-2 nucleocapsid SARS-CoV-2-positive patients tomography transbronchial Transbronchial lung cryobiopsy Treatment two patients was performed [DOI] 10.1007/s00428-020-02934-1 PMC 바로가기 [Article Type] Original Article
Antifibrotics in COVID-19 Lung Disease: Let Us Stay FocusedMedicine Published on 2020-09-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute lung injury acute respiratory distress antifibrotics approved ARDS autopsy studies clinical trial clinically coronavirus disease COVID - 19 COVID-19 curative drugs effective FDA fibrosis full recovery lung Lung disease Lung fibrosis Lung function MERS (middle east respiratory syndrome) outcome pathological finding patients with COVID-19 Perspective Prevalence Repurposed drug Research SARS SARS - CoV-2 severe viral pneumonia shown survivor Survivors syndrome Therapies therapy treat while [DOI] 10.3389/fmed.2020.00539 PMC 바로가기 [Article Type] Medicine
Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to ConsiderImmunology Published on 2020-08-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accompanied alleviate approach Biomarker COVID-19 COVID-19 case COVID-19 disease COVID-19 patient Cytokine storm described events Evidence feasible fibrosis galectin-3 Infection Inflammatory response life-threatening Lung fibrosis molecule plasma Prognosis progression Regulation resource Symptom target utility [DOI] 10.3389/fimmu.2020.02069 PMC 바로가기 [Article Type] Immunology
Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction StrategiesReview Article Published on 2020-08-102022-10-29 Journal: Pulmonary Medicine [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory distress advanced age Autopsy clinically complicate connective tissue COVID-19 COVID-19 infection Diseases disorders effective evaluate Evidence Factor fibrosis ICU Illness severity indicated Infection inflammatory phase initial lung lung dysfunction Lung fibrosis Lung injury measure mechanical ventilation medications MERS occur Pathogenesis pathology predictor pulmonary pulmonary fibrosis Radiographic respiratory infections risk risk factor risk reduction SARS-CoV-2 severe lung injury severity smoking Strategy Support syndrome targeted therapy the disease [DOI] 10.1155/2020/6175964 PMC 바로가기 [Article Type] Review Article
Tiotropium Is Predicted to Be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway AnalysisArticle Published on 2020-07-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome addition Affect Airway inflammation Antiviral approaches bioinformatics caused Cell chronic obstructive complex Comprehensive COPD coronavirus coronavirus disease COVID-19 COVID-19 patients deregulated drug effective enrichment analyses epithelial expression Genes IL1B IL6 IL8 IMPROVE in vitro in vivo indicated Infection inhibit Interaction Lung fibrosis molecular molecular pathways negative regulation NFkB1 NFKB2 NHBE Ontology outbreak pathologic feature pathway Pathways Patient patients predicted pulmonary disease Pulmonary function Rapamycin reduced RELA RelB Remdesivir Replication rheumatoid arthritis RNA-Seq RNA-seq data SARS-CoV-2 shown significantly the SARS-CoV-2 therapeutic intervention tiotropium TNF upregulated upregulation [DOI] 10.3390/v12070776 PMC 바로가기 [Article Type] Article
The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 PatientsReview Published on 2020-07-162022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE ACE2 Administered Arm Asthma cardiac dysfunction Combination COVID-19 COVID-19 patient Critical downstream eosinophil hypertension Hypothesis hypoxia IL-10 in vivo inhibit inhibitor Lung fibrosis Mas receptor mechanisms pathway Patient positive positive feedback loop Prevent RAS rationale renin-angiotensin system SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 Stage sustained System target the disease triggered upregulated [DOI] 10.3390/cells9071704 PMC 바로가기 [Article Type] Review
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosisResearch Published on 2020-07-142022-10-28 Journal: Respiratory Research [Category] COVID-19, SARS, [키워드] ACE2 activate acute lung injury acute respiratory syndrome ADAM17 Affect AGT angiotensin-converting enzyme 2 assist bind binding bioinformatic analysis cellular receptor change cleaved connective tissue coronavirus COVID-19 CTGF dataset disease domain driver endothelial enzyme epithelial cell FN1 growth factor host cells human epithelial cell human lung induce Lung epithelial cells Lung fibrosis lung tissue mechanism metalloproteinase mRNA pandemic disease patients promote Protein protein expression Result SARS-CoV-2 SARS-COV-2 infection specific treatment TGFB1 Tissue Inhibitor TMPRSS2 transcriptional transmembrane serine protease Vascular VEGF viral entry were expressed were measured [DOI] 10.1186/s12931-020-01445-6 PMC 바로가기 [Article Type] Research
Cannabinoid Receptor Type 2: A Possible Target in SARS-CoV-2 (CoV-19) Infection?Review Published on 2020-05-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Anti-inflammatory cannabinoid cannabinoid receptor type 2 cause cells circulating COVID-19 COVID-19 pandemic Cytokine storm death endocannabinoids system ENhance Estrogen Estrogens exacerbated excessive inflammation global pandemic immune cells immune response immune responses Inflammation Inflammatory limit Lung fibrosis Macrophage macrophage phenotype Mild modulating molecular target Novel coronavirus Patient Prevalence pro-inflammatory pro-inflammatory cytokines protective role receptor respiratory tract SARS-CoV-2 SARS-COV-2 infection small vessel susceptibility target Therapeutic strategies therapeutic target thrombosis Type women Wuhan, China [DOI] 10.3390/ijms21113809 PMC 바로가기 [Article Type] Review
miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction [DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article
Roles of TNF -α gene polymorphisms in the occurrence and progress of SARS-Cov infection: A case-control studyResearch Article Published on 2008-02-292022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] 95% CI acute respiratory syndrome adjusted Analysis association carried case-control study collected data compared conducted cured determine discharged fibrosis found Genetic polymorphism Genotype glucocorticoid Health care worker healthy controls Host genetic factor Infection interstitial locus Logistic lung Lung fibrosis manifested Necrosis not affect Occurrence PCR polymorphism prognosis of patient promoter region protective effect relationship Result risk risk factor role SARS patient SARS patients SARS-CoV infection Sequencing SNP susceptibility TNF TNF-α was used [DOI] 10.1186/1471-2334-8-27 PMC 바로가기 [Article Type] Research Article