Molecular recognition in the infection, replication, and transmission of COVID-19-causing SARS-CoV-2: an emerging interface of infectious disease, biological chemistry, and nanoscience Reviews Published on 2021-02-052022-10-05 Journal: NPG Asia Materials [Category] 변종, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive addition angiotensin-converting enzyme 2 Antiviral binding coronavirus coronavirus disease CoV CoV infection COVID-19 CoVs develop epithelial cell form function Genome glycans Host host cell Human IFN IFNs immune response Immunity immunology infected with SARS-CoV-2 Infection Infectious disease interferon involved macaque mechanism Medicine mutated Mutation N-acetylneuraminic acid nuclear outbreak pandemic Pandemics pathway physician platform progeny virion protease Protein receptor Replication researchers RNA SARS-CoV SARS-CoV-2 secretion serine 2 severity SGP sialic acid specificity spike glycoprotein stimulate Structure Symptom the cytokine storm the SARS-CoV-2 Toll-like receptor Transcription transmembrane Transmission Vaccine virus Wuhan [DOI] 10.1038/s41427-020-00275-8 [Article Type] Reviews
Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure공기 중 노출을 이용한 코로나바이러스 질병 2019 비인간 영장류 모델 개발Research Article Published on 2021-02-022022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] abnormality addition African green monkey African green monkeys alveolar Aside coronavirus disease correlation correlations COVID-19 Critical disease cynomolgus macaque cynomolgus macaques determine development Disease progression exposure to Fever fibrosis green green monkeys hyperplasia Infection investigated lung tissue macaque macaques parameter predicted prevalent replicate respiratory rhesus macaques SARS-CoV-2 thrombocytopenia Transmission Transmission model transmission of SARS-CoV-2 Type type II pneumocyte hyperplasia Viral viral shedding was measured was performed [DOI] 10.1371/journal.pone.0246366 PMC 바로가기 [Article Type] Research Article
BNT162b vaccines protect rhesus macaques from SARS-CoV-2 Research Published on 2021-02-012022-10-05 Journal: Nature [Category] SARS, 비임상, 유전자 메커니즘, [키워드] Antibody Response BNT162b BNT162b1 BNT162b2 candidate candidate vaccine CD4+ COVID-19 disease domain dose dose-dependent effective elicit ENCODE evaluated Evidence full-length geometric mean titre Germany human ACE2 human sera immunize immunogen intramuscular Lipid nanoparticles Lower respiratory tract macaque Messenger RNA mice Phase I populations prefusion conformation proline PROTECT RBD residue rhesus macaque S glycoprotein Safe SARS-CoV-2 secreted spike glycoprotein T cell responses titre transmembrane Trial trimer vaccination Vaccine vaccine candidate Viral RNA [DOI] 10.1038/s41586-021-03275-y [Article Type] Research
Correlates of protection against SARS-CoV-2 in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2에 대한 보호 상관 관계Article Published on 2021-02-012022-09-12 Journal: Nature [Category] MERS, SARS, 진단, [키워드] abrogated acute respiratory syndrome Antibody Response Antibody titre antibody titres CD8 Cellular immune response cellular immunity contribute convalescent coronavirus Depletion dose-dependent Efficacy humoral IgG Immunity implication infection with SARS-CoV-2 macaque macaques natural immunity PROTECT Protective purified recent reported required rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine T cell therapeutic agents transfer Treatment [DOI] 10.1038/s41586-020-03041-6 PMC 바로가기 [Article Type] Article
Animal models for SARS-CoV-2 research: A comprehensive literature reviewReview Published on 2021-01-252023-06-14 Journal: Transboundary and emerging diseases [Category] MERS, SARS, [키워드] animal model ferret hamster macaque mice pathophysiology SARS-CoV-2 [DOI] 10.1111/tbed.13907 PMC 바로가기 [Article Type] Review
Comparison of Subgenomic and Total RNA in SARS-CoV-2-Challenged Rhesus MacaquesVaccines and Antiviral Agents Published on 2021-01-202022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] administration anatomical antiviral drugs cell entry convalescent Critical Developing Efficacy genomic RNA gRNA in vivo inactivated infected cell Infection lysates macaque marker MONITOR monoclonal antibodies neutralized non-human primates nucleocapsid positive Prophylactic Protective public health remained replicating virus respiratory respiratory virus reverse transcription PCR rhesus macaque rhesus macaques RNA RNase RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 virus sgRNA subgenomic RNA the SARS-CoV-2 virus therapeutic therapeutic efficacy Total total RNA utility Vaccines Viral load virions virus [DOI] 10.1128/JVI.02370-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling MethodPharmacology Published on 2021-01-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulated analyzed AUC biodistribution Blood Brain Clinical studies collected Concentration conducted Course cynomolgus macaque cynomolgus macaques decrease demonstrated descending described Determining distribution dosing regimen elimination rate constant euthanized evaluate faster fat group HCQ Hydroxychloroquine kidney liver lung lung tissue macaque modeling pharmacokinetic PK parameter plasma Population Population pharmacokinetics protein precipitation Quantitative receive red blood cells Result single dose spleen suggested time-dependent tissue tissues translation treatment regimen Urine Volume was determined [DOI] 10.3389/fphar.2020.602880 PMC 바로가기 [Article Type] Pharmacology
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets붉은털원숭이, 개코원숭이 및 마모셋 폐의 SARS-CoV-2 급성 감염에 대한 반응Article Published on 2021-01-012022-09-12 Journal: Nature Microbiology [Category] MERS, SARS, 진단, [키워드] acute infection acute respiratory syndrome adaptive age antibody Baboon Bronchoalveolar lavage bystander Cellular immune response Clinical sign clinical trials Computed tomography coronavirus coronavirus disease COVID-19 cytokine production cytokine response distress group humans Immune cell immunohistochemical analyses Infection interferon response lung Lung inflammation Lungs macaque macaques memory Mild moderate Non-human Pathologies progression response rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG T-cell Therapies titre Vaccine viral infection Viral RNA shedding was increased [DOI] 10.1038/s41564-020-00841-4 PMC 바로가기 [Article Type] Article
Natural Plasmodium infection in wild macaques of three states in peninsular Malaysiaarticle Published on 2020-11-302024-09-01 Journal: Family process [Category] 말라리아, [키워드] macaque malaria Malaysia Plasmodium zoonosis [Article Type] article
NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challengeNVX-CoV2373 백신은 SARS-CoV-2 공격으로부터 사이노몰구스 마카크 상부 및 하부 기도를 보호합니다.Article Published on 2020-11-252022-09-12 Journal: Vaccine [Category] SARS, 진단, [키워드] anti-S antibody binding blocked clinical study COVID-19 Efficacy full-length SARS-CoV-2 glycoprotein hACE2 human Angiotensin-converting enzyme immunized Infection intranasal lower airway macaque Matrix-M Matrix-M adjuvant Neutralizing nonhuman primate NVX-CoV2373 NVX-CoV2373 nanoparticles NVX-CoV2373 vaccine prefusion conformation Prevent produced PROTECT Protective pulmonary disease receptor Safe SARS-CoV-2 spike spike glycoprotein Spread subunit Support Vaccine [DOI] 10.1016/j.vaccine.2020.10.064 PMC 바로가기 [Article Type] Article