Association Between SARS-CoV-2 Messenger RNA Vaccines and Lower Infection Rates in Kidney Transplant Recipients : A Registry-Based ReportObservational Study Published on 2022-07-012022-10-04 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI adjusted association Characteristics clinical Czech Republic Department Follow-up incidence rate kidney transplant recipient Lower lower risk Medicine messenger Messenger RNA Ministry of Health mRNA mRNA vaccination multivariable Nephrology Observational cohort study patient groups polymerase chain provided Rate recipient remains uncertain report risk RNA SARS-CoV-2 SARS-COV-2 infection Transplant vaccination Vaccine [DOI] 10.7326/M21-2973 PMC 바로가기 [Article Type] Observational Study
Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines Research Published on 2022-06-252022-10-05 Journal: Nature Communications [Category] 치료기술, [키워드] 95% CI 95% confidence interval adjusted odds ratio age analysed association BNT162b2 case-control study estimate females France group groups hospital discharge increased risk male Messenger RNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine myocarditis occurred reported risk second dose Sex vaccination Vaccine [DOI] 10.1038/s41467-022-31401-5 [Article Type] Research
Immune Response and Safety of SARS-CoV-2 mRNA-1273 Vaccine in Patients With Myasthenia Gravis중증 근무력증 환자에서 SARS-CoV-2 mRNA-1273 백신의 면역 반응 및 안전성Observational Study Published on 2022-06-212022-09-12 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI activity adverse event AEs baseline blood sample cellular Cellular immune response cellular response changes in class classification clinical clinically collected Combined therapy conducted coronavirus disease correlated country Course COVID-19 determine doses Efficacy ELISA Evidence first dose humoral immune response immunosuppressive drug immunosuppressive therapy induce interferon gamma Messenger RNA mRNA mRNA vaccination mRNA-1273 mRNA-1273 vaccine Myasthenia occurred Participants Patient performed plasma Prednisone Primary outcome Prospective Study provide receiving response Safe Safety SARS-CoV-2 second dose Seroconversion significant changes in statistically significant Surveillance Symptom T-cell T-cell Response the disease the patient vaccination vaccination schedule Vaccine were assessed were measured worsening [DOI] 10.1212/NXI.0000000000200002 PMC 바로가기 [Article Type] Observational Study
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR Research Published on 2022-06-132022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] Activation Antigen-specific T cells antigens breakthrough infections Cell cellular immunity chemokine correlated CXCL10 expression functional helping IFN-γ Immunity magnitude Messenger RNA monocyte mRNA normalized PCR populations protective immune response quantification quantitative PCR Rapid revaccination risk RNA extraction SARS-CoV-2 SARS-CoV-2 viral secrete stimulate T cell T cell activation [DOI] 10.1038/s41587-022-01347-6 [Article Type] Research
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 SecretionIFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus [DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model코로나바이러스 질환 2019(COVID-19) mRNA 백신의 정맥 주사가 마우스 모델에서 급성 심근염을 유발할 수 있음Article Published on 2022-06-102022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antigen expression Apoptosis Ballooning degeneration Blood Can cardiac Cardiac pathology change changes clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 mRNA vaccine different time point dose Evidence evidenced hepatocyte histological change histopathological IL-6 immunization immunostaining in vivo induce infiltrating immune cell inflammatory cell infiltration injection interferon intracardiac intramuscular intravenous Intravenous injection Messenger RNA mice Model mouse mouse model mRNA mRNA expression mRNA vaccine myocytes Myopericarditis Necrosis other organ provided reduce reported risk SARS-CoV-2 serum Serum level significantly significantly higher skeletal tissue Vaccine vaccine injection Vaccines vascular endothelial cells visceral weight loss Withdrawal [DOI] 10.1093/cid/ciab707 PMC 바로가기 [Article Type] Article
A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19시스템 생물학 접근 방식으로 COVID-19 중증 환자의 사망률을 줄이기 위한 후보 약물 식별Article Published on 2022-06-032022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus applied approach attribute candidate candidate drug caused coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 Critically ill Critically ill patient critically ill patients drug target drug treatment effective Epigenetic Hospital admission host response identify interferon interferon signaling lack Messenger RNA metabolism monocyte Mortality Nintedanib Ordinal Scale pathway Pathways Patient patients hospitalized reduce mortality RNA splicing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severely ill patient severely ill patients Systems biology tacrolimus therapeutic transcriptomic Treatment Vaccines with COVID-19 Zotatifin [DOI] 10.1126/sciadv.abm2510 PMC 바로가기 [Article Type] Article
Rituximab Impairs B Cell Response But Not T Cell Response to COVID-19 Vaccine in Autoimmune Diseases리툭시맙은 자가면역 질환에서 COVID-19 백신에 대한 B 세포 반응을 손상시키지만 T 세포 반응을 손상시키지 않습니다Article Published on 2022-06-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence activated anti-spike antibody response anti-Spike IgG Antibody Response Autoimmune disease autoimmune disease patient BNT162b2 CD4 CD8 CD8 T cell cellular response control group COVID-19 COVID-19 vaccine cytokine dose flow cytometry functional healthy control healthy controls humoral Immunosuppressant immunosuppressants interferon-γ Messenger RNA mRNA Necrosis Neutralization assay neutralizing antibody not different Patient patients patients treated performed Pfizer-BioNTech proportion Responder response rituximab RTX SARS-CoV-2 peptide SARS-CoV-2 spike peptide shown staining T cell response the healthy the vaccine time treated vaccine dose [DOI] 10.1002/art.42058 PMC 바로가기 [Article Type] Article
Construction and characterization of two SARS-CoV-2 minigenome replicon systems2개의 SARS-CoV-2 미니게놈 복제 시스템의 구성 및 특성화Article Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral Antiviral agents antiviral responses Antiviral treatment biosafety biosafety level cell line cell lines cellular cellular effect characterization complementary Complementary DNA construction coronavirus COVID-19 pandemic demonstrated disease disease control DNA early phase exhibited facilitate generate global public health Host immune immune responses Impact in vitro transcription inhibitors initial Innate immunity level 2 Messenger RNA mRNA mRNA transfection mRNA/splicing nLuc phenotype portion promise Replication reporter Research SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Support Transcription transfection transient transfection variety Virology virus virus classification [DOI] 10.1002/jmv.27650 PMC 바로가기 [Article Type] Article
Immune response and adverse events after vaccination against SARS-CoV-2 in adult patients with transfusion-dependent thalassaemia수혈 의존성 지중해빈혈 성인 환자에서 SARS-CoV-2 백신 접종 후 면역 반응 및 부작용Article Published on 2022-06-012022-09-12 Journal: British Journal of Haematology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adverse event comparable coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 dysfunction Immunity Infection Messenger RNA Mild Patient Protective antibody reaction reported SARS-CoV-2 severe COVID-19 thalassaemia the healthy therapy vaccination Vaccine Vaccines [DOI] 10.1111/bjh.18146 PMC 바로가기 [Article Type] Article