MicroRNAs – Page 8 – Communicable Diseases Research

Tackling the COVID-19 “cytokine storm” with microRNA mimics directly targeting the 3’UTR of pro-inflammatory mRNAs

Article

Published on 2021-01-012023-07-12
Journal: Med Hypotheses [Category] SARS,

Circulating non-coding RNAs as potential diagnostic biomarkers in liver diseases

Review Article

Published on 2021-01-012023-08-30
Journal: Gastroenterology and Hepatology From Bed to Bench [Category] E형 간염,

[키워드] chronic disease circulating biomarkers liver diseases MicroRNAs Non-coding RNAs Viral hepatitis
PMC 바로가기 [Article Type] Review Article

Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy

COVID-19 치료의 잠재적 표적인 TMPRSS2 유전자의 구조적 다양성, 발현 프로필 및 약리학적 특성

Article

Published on 2020-12-252022-09-10
Journal: Genes [Category] MERS, SARS, 변종, 치료기술, 치료제,

[키워드] ACE2 acetaminophen acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar cell alveolar cells Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asian Basigin BSG co-expressed copy number copy number variant coronavirus COVID-19 COVID-19 therapy Curcumin distribution downregulate drug enzyme European populations ExoN expression expression levels frequencies Frequency genome-wide data human cells human population human populations Interaction interactions involved lung microRNA MicroRNAs Missense mutation Paracetamol pharmacotranscriptomics Polymorphisms Population Potential predicted priming profile profiles property Prostate cancer Protein ranged receptor regulate Regulation respiratory respiratory tract cells SARS-CoV-2 SARS-CoV-2 cell Serine serine 2 serine protease severe acute respiratory syndrome Coronavirus significantly higher Single-cell RNA sequencing single-nucleotide Single-nucleotide polymorphisms SNV target therapy tissue-specific expression TMPRSS2 Variability
[DOI] 10.3390/genes12010019 PMC 바로가기 [Article Type] Article

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

세로 전사체 분석은 COVID-19에서 회복하는 동안 강력한 T 세포 면역을 보여줍니다

Article

Published on 2020-12-242022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis AP-1 Clinical features Clinical stages convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creation differentially expressed differentiation disease downregulated driven by event Genome informatics Humoral immunity immune protection immune regulation immune response immune responses Immunity indicated Infectious diseases long non-coding RNA longitudinal Messenger RNA messenger RNAs microRNA MicroRNAs miRNAs mononuclear cell mRNAs occurred Patient PBMC performed Peripheral blood regulatory network rehabilitation respiratory RNA sequencing robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly T cell T-cell activation Transcriptome Treatment type I interferon type I interferon response understanding
[DOI] 10.1038/s41392-020-00457-4 PMC 바로가기 [Article Type] Article

Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2

SARS-CoV-2에 감염된 햄스터 폐 조직에서 MicroRNA의 발현 분석

Article

Published on 2020-11-302022-09-11
Journal: Molecules and cells [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADAM17 binding caused coronavirus coronavirus disease Coronavirus disease 2019 cough COVID-19 diagnostic biomarker Diagnostic biomarkers differential expression Dyspnea examined expression expression pattern expression patterns Fever genome sequence Genome sequences hamster hamster lung hsa-miR-15a-5p hsa-miR-15b-5p hsa-miR-195-5p Infection infection mechanism Infectious disease lung lung tissue lung tissues lung; MERS MERS-CoV microRNA MicroRNAs Middle East miR-195-5p miRNA miRNAs Pneumonia receptor proteins Research respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe symptoms TMPRSS2
[DOI] 10.14348/molcells.2020.0177 PMC 바로가기 [Article Type] Article

The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection

Review

Published on 2020-11-132022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 1918 influenza acute COVID-19 acute respiratory syndrome adaptive immune system airway alteration Antiviral antiviral immune response Cell cellular cellular processe concerning contribute coronavirus Coronavirus infection correlated COVID-19 COVID-19 pandemic COVID-19 pathogenesis diagnosing disorders ectopic expression effort epithelial cell Evidence expression functions H1N1 Host human population immune response immune system Infection infections Influenza virus involved means mechanism microRNA MicroRNAs miRNA miRNA expression miRNAs mitigate noncoding RNA notable novel coronavirus disease nucleotide pandemic pandemic of COVID-19 Pathogenesis problem progression promote public health Regulation respiratory syncytial virus respiratory viruses rhinovirus RSV SARS-CoV-2 severity of COVID-19 target gene therapeutic therapeutic strategy Treatment viral infections viral respiratory infection virus viruses
[DOI] 10.1016/j.intimp.2020.107204 PMC 바로가기 [Article Type] Review

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19

Research Article

Published on 2020-10-112022-10-31
Journal: Clinical and Translational Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome addition Analysis Biomarker Blood blood transcriptome Cell cell types coding comprehensive view coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical defined Disease progression downstream expression function global pandemic Human immune system Hyperactivation Immune cell immune dysregulation immune regulator immune response Infection microRNA MicroRNAs miRNAs moderate mRNA mRNAs noncoding RNA Noncoding RNAs Pathogenesis Patient performed peripheral immune response Potential biomarker profile Result RNA SARS‐CoV‐2 Sequencing severe patients suggested T‐cell the disease therapeutic target therapeutic targets transcriptional transcriptome profile Whole blood
[DOI] 10.1002/ctm2.200 PMC 바로가기 [Article Type] Research Article

The Neat Dance of COVID-19: NEAT1, DANCR, and Co-Modulated Cholinergic RNAs Link to Inflammation

COVID-19의 깔끔한 춤: NEAT1, DANCR 및 공동 조절 콜린성 RNA가 염증과 연결

Immunology

Published on 2020-10-092022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘,

[키워드] Accompanying ACE2 Acetylcholine acetylcholine signaling age Analysis association bioinformatics Blood Blood cells Brain candidate Cell culture cellular Central nervous system changes in cholinergic cholinergic neurons coding transcript coding transcripts cognitive Cohort Complication Consequences COVID-19 COVID-19 infection COVID-19 pandemic Dance DANCR Decline decrease diagnostic diagnostics donors expression followed by H1N1 H1N1 influenza human lung identify increase increases in infected cell Infection Inflammation Inflammatory Influenza inter-individual involved long non-coding RNA lung lung cell lung cells lung tissue lung tissues manifestation medication men and women MicroRNAs miRNA ncRNA ncRNAs NEAT1 Neurological complications Neuron non-coding RNA nuclear parasympathetic Post-infection predicted profiles qRT-PCR Quantitative reflected risk RNA RNA-seq dataset RNA-sequencing SARS-CoV-2 selected shifting Signaling statins Supporting susceptibility TFS therapeutic tissue tissue-specific expression tissues transcript transcription factor transcription factors transcriptomic transcripts Variability viruses weakened with COVID-19 woman
[DOI] 10.3389/fimmu.2020.590870 PMC 바로가기 [Article Type] Immunology

SARS-CoV infection crosstalk with human host cell noncoding-RNA machinery: An in-silico approach

인간 숙주 세포 noncoding-RNA 기계와 SARS-CoV 감염 누화: 인-실리코 접근

Article

Published on 2020-10-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] Coronavirus, SARS, 유전자 메커니즘,

[키워드] antiviral defense mechanism antiviral drug antiviral drugs approach Bioinformatics analysis caused Cell computational analysis coronavirus CoV infection COVID-19 defense mechanisms defined develop drug Efficacy engage Gene Expression Genome globe host cells human disease human host human host cell human host cells humans in-silico Infection Interaction investigated involved lncRNA Long MicroRNAs miRNA miRNAs mortality rate noncoding RNA Noncoding RNA, miRNA, lncRNA Noncoding RNAs Novel coronavirus outbreak Pathogenesis pathway Pathways post-transcriptionally potential therapeutic targets Proteins public health regulate Regulatory RNA SARS-CoV SARS-CoV infection shown signaling pathway TGF-beta TGF-beta signaling therapy transcribed transcript transcripts translated Vaccine virus
[DOI] 10.1016/j.biopha.2020.110548 PMC 바로가기 [Article Type] Article

ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives

Molecular Biosciences

Published on 2020-09-302022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] “cytokine storm” accumulates ACE ACE inhibitor ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome Administered Alter Angiotensin receptor blockers angiotensin-converting enzyme 2 antibodies appear binding biochemical Biochemistry cardioprotection cardiovascular system cellular clinical investigation competitive binding COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm determinant downregulation drugs Effect effort engage enzyme Epigenetic event Evidence exogenously forms glycosylation Host host cell membrane hypertension induce Infection initial Interaction intestine kidney knowledge limit Lung inflammation mammalian mechanism Medical conditions MicroRNAs modulation Neutralizing novel observation pathogenicity pathophysiological pathophysiology peptides Phosphorylation plasma membrane Protein reduce reduced regulated Replication respiratory tract responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe COVID-19 small molecule Spike protein Strategy subunits: S1 tissues transcriptional viral envelope viral genome virus virus entry
[DOI] 10.3389/fmolb.2020.588618 PMC 바로가기 [Article Type] Molecular Biosciences